cis-cyclohexane-1,2-diammonium sulfate | 65433-80-9

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: cis-cyclohexane-1,2-diammonium sulfate
• 英文别名: 1,2-Cyclohexanediamine sulfate；(1R,2S)-cyclohexane-1,2-diamine;sulfuric acid
• CAS: 65433-80-9
• 化学式: C₆H₁₄N₂*H₂O₄S
• 分子量: 212.27
• InChiKey: RZGUMENMNJEUSQ-KNCHESJLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.44
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  135
• 氢给体数：
  4
• 氢受体数：
  6

安全信息

• 危险类别码：
  R20/21/22
• 海关编码：
  2921300090
• 安全说明：
  S22,S36

反应信息

• 作为反应物：
  描述：

  cis-cyclohexane-1,2-diammonium sulfate 在 sodium hydroxide 作用下， 以 水 为溶剂， 反应 1.17h， 以67%的产率得到Cis-1,2-diaminocyclohexane
  参考文献：
  名称：

  Synthesis of cis-TMCDA: Optimization and characterization of a key intermediate

  摘要：

  We report optimized synthetic procedures to cis-TMCDA and cis-cyclohexane-1,2-diamine. Our new two-step approach is an efficient and low-cost method for synthesizing the ligand cis-TMCDA. In the preparation of cis-cyclohexane-1,2-diamine, the crystallization of the unexpected intermediate cis-cyclohexane-1,2-diammonium hydrogensulfate ethylsulfate made the subsequent reactions easier in their workup, as nickel(II) chloride impurities were eliminated. (C) 2011 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.ica.2011.06.008
• 作为产物：
  描述：

  1,2-二氨基环己烷 在 nickel(II) chloride hexahydrate 、 乙醇 、 硫酸 作用下， 以 甲醇 为溶剂， 反应 24.0h， 以10.1 g的产率得到cis-cyclohexane-1,2-diammonium sulfate
  参考文献：
  名称：

  Synthesis of cis-TMCDA: Optimization and characterization of a key intermediate

  摘要：

  We report optimized synthetic procedures to cis-TMCDA and cis-cyclohexane-1,2-diamine. Our new two-step approach is an efficient and low-cost method for synthesizing the ligand cis-TMCDA. In the preparation of cis-cyclohexane-1,2-diamine, the crystallization of the unexpected intermediate cis-cyclohexane-1,2-diammonium hydrogensulfate ethylsulfate made the subsequent reactions easier in their workup, as nickel(II) chloride impurities were eliminated. (C) 2011 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.ica.2011.06.008

文献信息

• New antineoplastic platinum (IV) complexes
  申请人：THE UNITED STATES OF AMERICA as represented by the Secretary United States Department of Commerce

  公开号：EP0154589A2

  公开（公告）日：1985-09-11

  New substantially isomerically pure tetrahalo (1,2-diaminocyclohexane) Pt (IV) complexes having antineoplastic activity are disclosed.

  本研究公开了具有抗肿瘤活性的新的基本同分异构纯四卤（1,2-二氨基环己烷）铂（IV）络合物。
• US4599352A
  申请人：——

  公开号：US4599352A

  公开（公告）日：1986-07-08
• Synthesis of cis-TMCDA: Optimization and characterization of a key intermediate
  作者：Prisca K. Eckert、Verena Schill、Carsten Strohmann

  DOI：10.1016/j.ica.2011.06.008

  日期：2011.10

  We report optimized synthetic procedures to cis-TMCDA and cis-cyclohexane-1,2-diamine. Our new two-step approach is an efficient and low-cost method for synthesizing the ligand cis-TMCDA. In the preparation of cis-cyclohexane-1,2-diamine, the crystallization of the unexpected intermediate cis-cyclohexane-1,2-diammonium hydrogensulfate ethylsulfate made the subsequent reactions easier in their workup, as nickel(II) chloride impurities were eliminated. (C) 2011 Elsevier B.V. All rights reserved.