2-[[(2R)-2,3-di(decanoyloxy)propoxy]-hydroxyphosphoryl]oxyethyl-trimethylazanium

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油磷脂
• 英文名称: 2-[[(2R)-2,3-di(decanoyloxy)propoxy]-hydroxyphosphoryl]oxyethyl-trimethylazanium
• 化学式: C28H57NO8P+
• 分子量: 566.7
• InChiKey: MLKLDGSYMHFAOC-AREMUKBSSA-O

计算性质

• 辛醇/水分配系数(LogP)：
  7
• 重原子数：
  38
• 可旋转键数：
  28
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  108
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• Method for preparing liposome comprising ultrasound reactive microbubble for drug delivery and liposome using same
  申请人：BIOINFRA LIFE SCIENCE INC.

  公开号：US11504328B2

  公开（公告）日：2022-11-22

  Provided are a method for preparing liposomes comprising ultrasound reactive microbubbles for drug delivery, comprising (a) a step of producing ultrasound reactive microbubbles comprising an inert gas therein and having a first shell formed on the outer surface thereof, followed by forming a uniform size distribution of the ultrasound reactive microbubbles through an extruder; and (b) a step of producing liposomes comprising the ultrasound reactive microbubbles distributed in a uniform size and a medicament therein and having a second shell formed on the outer surface thereof, followed by forming a uniform size distribution of the liposomes through an extruder; and a liposome using same.

  本发明提供了一种用于制备包含超声反应微泡的脂质体的方法，该方法用于给药，包括：(a) 第一步，生产包含惰性气体的超声反应微泡，并在其外表面形成第一外壳，然后通过挤压机形成大小分布均匀的超声反应微泡；和 (b) 生产脂质体的步骤，脂质体包括以均匀尺寸分布的超声反应微泡和其中的药物，并在其外表面形成第二外壳，然后通过挤压机形成均匀尺寸分布的脂质体；以及使用相同方法的脂质体。
• METHODS FOR PROMOTING TRAINED IMMUNITY WITH NANOBIOLOGIC COMPOSITIONS
  申请人：ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

  公开号：US20200261591A1

  公开（公告）日：2020-08-20

  The invention relates to therapeutic nanobiologic compositions and methods of treating patients who have cancer, by promoting trained immunity, which is the long-term increased responsiveness, the result of metabolic and epigenetic re-wiring of myeloid cells and their stem cells and progenitors in the bone marrow and spleen and blood induced by a primary insult, and characterized by increased cytokine excretion after re-stimulation with one or multiple secondary stimuli.
• [EN] METHOD FOR PREPARING LIPOSOME COMPRISING ULTRASOUND REACTIVE MICROBUBBLE FOR DRUG DELIVERY AND LIPOSOME USING SAME<br/>[FR] PROCÉDÉ POUR LA PRÉPARATION DE LIPOSOMES COMPRENANT DES MICROBULLES ULTRASONORES RÉACTIVES POUR L'ADMINISTRATION DE MÉDICAMENTS ET LIPOSOME L'UTILISANT<br/>[KO] 약물전달을 위한 초음파 반응형 미소기포를 포함하는 리포좀 제조 방법 및 이를 이용한 리포좀
  申请人：BIOINFRA LIFE SCIENCE INC

  公开号：WO2019182353A1

  公开（公告）日：2019-09-26

  약물전달을 위한 초음파 반응형 미소기포를 포함하는 리포좀의 제조 방법에 있어서, (a) 내부에 불활성 가스를 포함하며 외면에 제1쉘이 형성된 초음파 반응형 미소기포를 생성한 이후 압출기를 통해 상기 초음파 반응형 미소기포의 크기 분포를 균일하게 형성하는 단계; 및 (b) 내부에 크기 분포가 균일하게 형성된 상기 초음파 반응형 미소기포와 약물을 포함하며 외면에 제2쉘이 형성된 리포좀을 생성한 이후 압출기를 통해 상기 리포좀의 크기 분포를 균일하게 형성하는 단계;를 포함하는 방법 및 이를 이용한 리포좀을 제공한다.
• [EN] TARGETED DRUG DELIVERY AND THERAPEUTIC METHODS USING APO-E MODIFIED LIPID NANOPARTICLES<br/>[FR] APPORT CIBLÉ DE MÉDICAMENT ET MÉTHODES THÉRAPEUTIQUES UTILISANT DES NANOPARTICULES LIPIDIQUES MODIFIÉES COMPRENANT APO-E
  申请人：ERIOCHEM USA LLC

  公开号：WO2019195377A1

  公开（公告）日：2019-10-10

  Methods for targeted delivery of therapeutic agents to a target cell or tissue with lipid nanoparticles comprising ApoE3. In embodiments, the invention specifically relates to targeted delivery of anticancer drugs, antibiotics, antifungal drugs, and diagnostic contrast agents, and associated treatment and diagnostic methods. In embodiments, diseases/conditions treated include those associated with over-expression of LDL receptors.
• [EN] EXTRACELLULAR VESICLES WITH NRAS ANTISENSE OLIGONUCLEOTIDES<br/>[FR] VÉSICULES EXTRACELLULAIRES AVEC DES OLIGONUCLÉOTIDES ANTISENS DE NRAS
  申请人：CODIAK BIOSCIENCES INC

  公开号：WO2021030769A1

  公开（公告）日：2021-02-18

  The present disclosure relates to modified extracellular vesicles, e.g., exosomes, comprising an antisense oligonucleotide (ASO), which is capable of reducing and/or inhibiting expression of NRas mRNA and/or NRas protein. ASOs that can be used with the modified extracellular vesicles are also disclosed. Also provided herein are methods for using the exosomes and ASOs to treat and/or prevent diseases, such as cancer.