2-[[(2R)-2,3-bis[[(Z)-tetradec-9-enoyl]oxy]propoxy]-hydroxyphosphoryl]oxyethyl-trimethylazanium

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油磷脂
• 英文名称: 2-[[(2R)-2,3-bis[[(Z)-tetradec-9-enoyl]oxy]propoxy]-hydroxyphosphoryl]oxyethyl-trimethylazanium
• 化学式: C36H69NO8P+
• 分子量: 674.9
• InChiKey: AVCZHZMYOZARRJ-JWLMTKEBSA-O

计算性质

• 辛醇/水分配系数(LogP)：
  9.5
• 重原子数：
  46
• 可旋转键数：
  34
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  108
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• Particulate-stabilized injectable pharmacutical compositions of posaconazole
  申请人：Witchey-Lakshmanan Leonore

  公开号：US20090226527A1

  公开（公告）日：2009-09-10

  The present invention provides formulations useful for treating infections, in particular, formulations that include the active pharmaceutical ingredient Posaconazole in an injectable suspension of particles that is stable when subjected to terminal sterilization. Preferred median particle sizes of between 1.5 and 3.0 microns are found to result in superior pharmacokinetic characteristics-displayed in FIG. 7.
• GAS-FILLED STABILIZED PARTICLES AND METHODS OF USE
  申请人：CHILDREN'S MEDICAL CENTER CORPORATION

  公开号：US20160030596A1

  公开（公告）日：2016-02-04

  Provided herein are various gas-filled particles having a stabilized membrane that encapsulates the gas. Pharmaceutical compositions, methods of use and treatment, and methods of preparation are also described.