(2-{Hydroxy-[2-octadecanoyloxy-3-((Z)-octadec-9-enoyloxy)-propoxy]-phosphoryloxy}-ethyl)-trimethyl-ammonium

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油磷脂
• 英文名称: (2-{Hydroxy-[2-octadecanoyloxy-3-((Z)-octadec-9-enoyloxy)-propoxy]-phosphoryloxy}-ethyl)-trimethyl-ammonium
• 英文别名: 2-[hydroxy-[2-octadecanoyloxy-3-[(Z)-octadec-9-enoyl]oxypropoxy]phosphoryl]oxyethyl-trimethylazanium
• 化学式: C₄₄H₈₇NO₈P
• 分子量: 789.15
• InChiKey: NMJCSTNQFYPVOR-XDOYNYLZSA-O

计算性质

• 辛醇/水分配系数(LogP)：
  14.8
• 重原子数：
  54
• 可旋转键数：
  43
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  108
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  L-α-Dioleoyl-lecithin 生成 (2-{Hydroxy-[2-octadecanoyloxy-3-((Z)-octadec-9-enoyloxy)-propoxy]-phosphoryloxy}-ethyl)-trimethyl-ammonium
  参考文献：
  名称：

  de Haas,G.H.; van Deenen,L.L.M., Tetrahedron Letters, 1960, # 22, p. 7 - 9

  摘要：

  DOI：

文献信息

• [EN] FLUOROPOLYMER EMULSIONS WITH BRANCHED SEMIFLUORINATED BLOCK COPOLYMER OR PHOSPHOLIPID SURFACTANT FOR THE DELIVERY OF HYDROPHOBIC DRUGS<br/>[FR] ÉMULSIONS DE FLUOROPOLYMÈRES COMPORTANT DES COPOLYMÈRES SÉQUENCÉS SEMI-FLUORÉS ET RAMIFIÉS OU UN TENSIOACTIF PHOSPHOLIPIDIQUE POUR L'ADMINISTRATION DE MÉDICAMENTS HYDROPHOBES
  申请人：WISCONSIN ALUMNI RES FOUND

  公开号：WO2015164781A1

  公开（公告）日：2015-10-29

  The present invention provides therapeutic formulations, including therapeutic nanoemulsions, and related methods for the in vivo delivery of hydrophobic compounds, including an important class of hydrophobic anesthetics. Formulations and methods of the invention include semifluorinated block copolymers, and optionally phospholipid surfactants, capable of forming a stable nanoemulsion without the need of conventional lipid components that support bacterial and/or fungal growth(e.g., soybean oil and similar lipids). In certain embodiments, emulsion-based formulations are provided that are capable of formulating, delivering and releasing amounts of hydrophobic drugs effective for a range of clinical applications, including inducing and maintaining anesthesia in patients. In certain embodiments, emulsion-based formulations are provided that are capable of supporting controlled release, for example, over a range of rates useful for clinical applications including rapid and sustained release.

  本发明提供了治疗配方，包括治疗纳米乳液，以及相关方法，用于体内传递疏水化合物，包括一类重要的疏水麻醉剂。本发明的配方和方法包括半氟化块共聚物，以及可选择的磷脂表面活性剂，能够形成稳定的纳米乳液，而无需传统的支持细菌和/或真菌生长的脂质成分（例如大豆油和类似脂质）。在某些实施例中，提供了基于乳液的配方，能够制备、传递和释放对一系列临床应用有效的疏水药物量，包括在患者中诱导和维持麻醉。在某些实施例中，提供了基于乳液的配方，能够支持受控释放，例如，在一系列对于临床应用有用的速率范围内，包括快速和持续释放。
• COMPOSITION FOR LASER ENGRAVING, RELIEF PRINTING PLATE PRECURSOR FOR LASER ENGRAVING AND PROCESS FOR PRODUCING SAME, PROCESS FOR MAKING RELIEF PRINTING PLATE, AND RELIEF PRINTING PLATE
  申请人：FUJIFILM CORPORATION

  公开号：US20140130692A1

  公开（公告）日：2014-05-15

  To provide a composition for laser engraving that can give a relief printing plate having excellent ink laydown and that has excellent rinsing properties after laser engraving. A composition for laser engraving, the composition that comprises (Component A) an acrylate oligomer; (Component B) a thermopolymerization initiator; and (Component C) at least one of the compounds represented by Formula (1) to Formula (7); the composition not comprising or comprising at more than 0 mass % but less than 2 mass % relative to the total mass of the composition (Component D) a resin having a weight-average molecular weight of at least 10,000, wherein R 1 to R 18 independently denote a hydrogen atom, an alkyl group, a substituted alkyl group, an aryl group, a substituted aryl group, a heterocyclic group, or a substituted heterocyclic group, L 2 denotes a divalent organic group, L 3 denotes a trivalent organic group, and L 4 denotes a tetravalent organic group.

  提供一种用于激光雕刻的组合物，可提供具有出色油墨覆盖和激光雕刻后具有出色冲洗性能的浮雕印刷版。该组合物包括（组分A）丙烯酸酯低聚物；（组分B）热聚合引发剂；以及（组分C）由式（1）至式（7）表示的至少一种化合物，该组合物不含有或相对于组合物的总质量含有不到2质量％但超过0质量％的树脂（组分D），其具有至少10,000的重均分子量，其中R1至R18独立地表示氢原子，烷基，取代烷基，芳基，取代芳基，杂环基或取代杂环基，L2表示二价有机基团，L3表示三价有机基团，L4表示四价有机基团。
• COMPOSITION FOR LASER ENGRAVING, RELIEF PRINTING ORIGINAL PLATE FOR LASER ENGRAVING AND PRODUCTION METHOD THEREFOR, PRODUCTION METHOD FOR RELIEF PRINTING PLATE, AND RELIEF PRINTING PLATE
  申请人：FUJIFILM Corporation

  公开号：EP2738009A1

  公开（公告）日：2014-06-04

  To provide a composition for laser engraving that can give a relief printing plate having excellent ink laydown and that has excellent rinsing properties after laser engraving. A composition for laser engraving, the composition that comprises (Component A) an acrylate oligomer; (Component B) a thermopolymerization initiator; and (Component C) at least one of the compounds represented by Formula (1) to Formula (7); the composition not comprising or comprising at more than 0 mass% but less than 2 mass% relative to the total mass of the composition (Component D) a resin having a weight-average molecular weight of at least 10,000, wherein R1 to R18 independently denote a hydrogen atom, an alkyl group, a substituted alkyl group, an aryl group, a substituted aryl group, a heterocyclic group, or a substituted heterocyclic group, L2 denotes a divalent organic group, L3 denotes a trivalent organic group, and L4 denotes a tetravalent organic group.         R1-CO2R2     ( 1 )         R3O2C-L2-CO2R4     ( 2 )         R12-CONHR13     ( 5 )         R14-SO2NHR15     ( 6 )

  提供一种用于激光雕刻的组合物，该组合物能使浮雕印版具有优异的油墨铺展性，并且在激光雕刻后具有优异的漂洗性能。 一种用于激光雕刻的组合物，该组合物包含（组分 A）丙烯酸酯低聚物；（组分 B）热聚合引发剂；以及（组分 C）至少一种由式（1）至式（7）表示的化合物；该组合物不包含或包含相对于组合物总质量大于 0 质量％但小于 2 质量％的树脂 (组分 D)，其重量-平均分子量至少为 10,000，其中 R1 至 R18 独立地表示氢原子、烷基、取代的烷基、芳基、取代的芳基、杂环基团或取代的杂环基团，L2 表示二价有机基团，L3 表示三价有机基团，L4 表示四价有机基团。 R1-CO2R2 ( 1 ) R3O2C-L2-CO2R4 ( 2 ) R12-conhr13 ( 5 ) R14-SO2NHR15 ( 6 )
• RESIN COMPOSITION FOR LASER ENGRAVING, RELIEF PRINTING PLATE PRECURSOR FOR LASER ENGRAVING AND METHOD FOR PRODUCING THE SAME, AND RELIEF PRINTING PLATE AND METHOD FOR MAKING THE SAME
  申请人：YOSHIDA Kenta

  公开号：US20110076613A1

  公开（公告）日：2011-03-31

  A resin composition for laser engraving, including at least a phenol derivative (A) represented by the following Formula (A), a binder polymer (B), and a crosslinking agent (C), wherein the content of the phenol derivative (A) with respect to the total solid content of the resin composition is from 5% by mass to 50% by mass:
• RELIEF PRINTING PLATE PRECURSOR FOR LASER ENGRAVING, PROCESS FOR MAKING RELIEF PRINTING PLATE, AND RELIEF PRINTING PLATE
  申请人：KAWASHIMA Takashi

  公开号：US20110293897A1

  公开（公告）日：2011-12-01

  A relief printing plate precursor for laser engraving is provided that includes above a support, as a crosslinked relief-forming layer, a thermally crosslinked layer of a resin composition for laser engraving that includes (Component A) a compound containing a hydrolyzable silyl group and/or a silanol group and that does not include (Component B) a binder polymer or includes it at less than 2 wt % relative to the total weight on a non-volatile component basis. There are also provided a process for making a relief printing plate that includes a step of preparing the relief printing plate precursor for laser engraving and a step of forming a relief layer by laser-engraving the crosslinked relief-forming layer, and a relief printing plate that includes a relief layer formed by the process for making a relief printing plate.