L-α-Dioleoyl-lecithin

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油磷脂
• 英文名称: L-α-Dioleoyl-lecithin
• 英文别名: Dioleoyl lecithin；2-[2,3-bis[[(Z)-octadec-9-enoyl]oxy]propoxy-hydroxyphosphoryl]oxyethyl-trimethylazanium
• 化学式: C₄₄H₈₅NO₈P
• 分子量: 787.135
• InChiKey: SNKAWJBJQDLSFF-YEUCEMRASA-O

计算性质

• 辛醇/水分配系数(LogP)：
  13.8
• 重原子数：
  54
• 可旋转键数：
  42
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  108
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  L-α-Dioleoyl-lecithin 生成 γ-Oleoyl-L-α-lysolecithin
  参考文献：
  名称：

  de Haas,G.H.; van Deenen,L.L.M., Tetrahedron Letters, 1960, # 22, p. 7 - 9

  摘要：

  DOI：

文献信息

• LIPID DERIVATIVE FOR NUCLEIC ACID INTRODUCTION
  申请人：NIPPON FINE CHEMICAL CO., LTD.

  公开号：US20200031853A1

  公开（公告）日：2020-01-30

  An object is to provide a lipid particle that is not positively charged at a pH of the body fluid (typically in the neutral range), and that enables efficient onset of the effect of a medicinal substance encapsulated in the lipid particle; and to provide a lipid for forming the lipid particle. The object is achieved by the phospholipid represented by formula (1), and a lipid particle containing the phospholipid: wherein R 1 and R 2 are identical or different, and represent a chain hydrocarbon group, m represents 1 or 2, n represents 1 or 2, and p represents an integer of 1 to 4.

  一种目的是提供一种在体液的pH（通常在中性范围）下不带正电荷的脂质颗粒，使脂质颗粒中包封的药物物质的效果能够高效发挥；并提供用于形成脂质颗粒的脂质。该目的通过由式（1）表示的磷脂类化合物和含有该磷脂类化合物的脂质颗粒实现：其中R1和R2相同或不同，代表链烃基，m代表1或2，n代表1或2，p代表1到4之间的整数。
• Compounds and Compositions for Nucleic Acid Formulation and Delivery
  申请人：Boylan John Frederick

  公开号：US20130072543A1

  公开（公告）日：2013-03-21

  The invention relates to compositions containing compounds of formula I: and pharmaceutically acceptable salts thereof, wherein R, R 1 , R 2 , R 3 , and n are defined in the detailed description and claims. In addition, the present invention relates to novel formulations containing compounds of formula I for improved delivery of nucleic acids such as siRNA to the cytoplasm of target cells. In particular embodiments these formulations comprise compounds of formula I, phospholipids, cholesterol, and pegylated lipids. The present invention also relates to methods of manufacturing and using such compounds and compositions.

  本发明涉及含有公式I化合物的组合物及其药学上可接受的盐，其中R、R1、R2、R3和n在详细描述和权利要求中定义。此外，本发明涉及新的公式I化合物的制剂，用于改善核酸如siRNA输送至靶细胞的细胞质。在特定实施例中，这些制剂包括公式I化合物、磷脂、胆固醇和聚乙二醇化脂质。本发明还涉及制备和使用这些化合物和组合物的方法。
• IMMUNOGENIC AMPHIPATHIC PEPTIDE COMPOSITIONS
  申请人：O'Hagan Derek

  公开号：US20110250237A1

  公开（公告）日：2011-10-13

  The present application pertains to a composition, comprising (a) amphipathic peptides; (b) lipids and (c) at least one immunogenic species. Respective compositions are suitable for immunogenic species transport and delivery, for example for systemic or local delivery to a mammal. Also provided are pharmaceutical compositions, comprising respective compositions. Methods of forming the foregoing are also provided.

  本申请涉及一种组合物，包括（a）两性胜肽；（b）脂质和（c）至少一种免疫原物种。各自的组合物适用于免疫原物种的运输和传递，例如用于系统性或局部传递到哺乳动物。还提供了药物组合物，包括各自的组合物。还提供了形成上述组合物的方法。
• REAGENT FOR INTRODUCTION OF PROTEIN OR GENE
  申请人：Takeoka Shinji

  公开号：US20100291672A1

  公开（公告）日：2010-11-18

  The present invention provides a reagent for introducing a protein or gene into a cell. The reagent of the present invention is, for example, a reagent for introducing a protein or gene into a cell, which comprises a composition comprising a cationic amino acid type lipid represented by the following formula (I)-1: (wherein in formula (I)-1: L is a single bond, —CONH—, or —S—S—; M 1 is —(CH 2 ) k — or —(CH 2 CH 2 O) k — (wherein k is an integer between 0 and 14); and m1 and m2 are each independently an integer between 11 and 21 (in this regard, when providing a reagent for introducing a gene into a cell, the case where both m1 and m2 are 15 is excluded)).

  本发明提供了一种用于将蛋白质或基因引入细胞的试剂。本发明的试剂例如是一种用于将蛋白质或基因引入细胞的试剂，包括以下式（I）-1所表示的阳离子氨基酸型脂质的组合物：（其中在式（I）-1中，L是单键，-CONH-或-S-S-；M1是-(CH2)k-或-(CH2CH2O)k-（其中k是0至14之间的整数）；m1和m2各自独立地是11至21之间的整数（在这方面，当提供一种用于将基因引入细胞的试剂时，排除m1和m2都为15的情况）。
• Advanced drug development and manufacturing
  申请人：Los Alamos National Security, LLC

  公开号：EP2511844A2

  公开（公告）日：2012-10-17

  There is described an apparatus for measuring protein characteristics comprising an X-ray fluorescence (XRF) spectrometer comprising a source of polychromatic X-rays, an X-ray detector, a protein, a molecule that has been exposed to and at least weakly binds to the protein, a plurality of X-ray fluorescence signal data obtained by irradiating chemical elements in the protein and molecule with the polychromatic X-rays and a security system for maintaining records for the data from the plurality of X-ray fluorescence signal measurements. There is also described an x-ray microscope for measuring a sample.

  描述了一种测量蛋白质特性的仪器，该仪器包括一个 X 射线荧光 (XRF) 光谱仪，其中包括一个多色 X 射线源、一个 X 射线探测器、一个蛋白质、一个已暴露于该蛋白质并至少与该蛋白质弱结合的分子、通过用多色 X 射线照射蛋白质和分子中的化学元素而获得的多个 X 射线荧光信号数据，以及一个用于维护多个 X 射线荧光信号测量数据记录的安全系统。此外，还介绍了一种用于测量样品的 X 射线显微镜。