1,2-Dicaproyl-sn-glycero-3-phosphocholine

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油磷脂
• 英文名称: 1,2-Dicaproyl-sn-glycero-3-phosphocholine
• 英文别名: 2-[[(2R)-2,3-di(hexanoyloxy)propoxy]-hydroxyphosphoryl]oxyethyl-trimethylazanium
• 化学式: C20H41NO8P+
• 分子量: 454.5
• InChiKey: DVZARZBAWHITHR-GOSISDBHSA-O

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  30
• 可旋转键数：
  20
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  108
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  二棕榈酸磷脂酰胆碱 以 氯仿 为溶剂， 以a solution of DHPC in chloroform up to a molar ratio DPPC/DHPC of q=3.5 was obtained的产率得到1,2-Dicaproyl-sn-glycero-3-phosphocholine
  参考文献：
  名称：

  Liposome-Encapsulated Bicelles and Use Thereof in Diluted Systems

  摘要：

  本发明的目的是在高含水环境中保持双胞球的形态。为此，本发明涉及一种脂质体，其在其内部水介质中至少含有一种双胞球。所述水介质中的双胞球浓度相对于最终脂质体的干重在5％至25％之间。本发明还涉及使用所述脂质体封装活性成分，以及将其用作药物或生产化妆品的用途。本发明还涉及获得所述脂质体的方法。

  公开号：

  US20120321683A1

文献信息

• Phospholipid nanogel for exoglycosidase enzyme stabilization
  申请人：West Virginia University

  公开号：US10894956B2

  公开（公告）日：2021-01-19

  Described herein are phospholipid nanogels that can contain a low concentration (less than about 250 μUnits/μL) of an exoglycosidase enzyme. Also described herein are systems and devices that can contain a phospholipid nanogel that can contain a low concentration (less than about 250 μUnits/μL) of an exoglycosidase enzyme. Also described herein are methods of using the phospholipid nanogels described herein and devices and systems that can contain a phospholipid nanogel described herein.

  本文描述的磷脂纳米凝胶可含有低浓度（小于约 250 μU单位/μL）的外糖苷酶。本文还描述了可含有低浓度（小于约 250 μ 单位/μL）外糖苷酶的磷脂纳米凝胶的系统和装置。本文还描述了使用本文所述磷脂纳米凝胶的方法以及可含有本文所述磷脂纳米凝胶的装置和系统。
• Therapies for treating and preventing chronic rhinosinusitis
  申请人：Avanti Polar Lipids, LLC

  公开号：US11413297B2

  公开（公告）日：2022-08-16

  The invention provides compositions and methods for disrupting preformed bacterial biofilm or preventing formation of bacterial biofilm. Also provided in the invention are methods and compositions for treating and preventing chronic rhinosinusitis. Such compositions and methods utilize one or more antibiotic compounds in combination with at least one phospholipid compound described herein.

  本发明提供了破坏已形成的细菌生物膜或防止形成细菌生物膜的组合物和方法。本发明还提供了治疗和预防慢性鼻炎的方法和组合物。此类组合物和方法利用一种或多种抗生素化合物与本文所述的至少一种磷脂化合物相结合。
• PREVENTION AND TREATMENT OF INFLAMMATORY CONDITIONS
  申请人：GRI Bio, Inc.

  公开号：EP3229811B1

  公开（公告）日：2021-02-24
• NOVEL THERAPIES FOR TREATING AND PREVENTING CHRONIC RHINOSINUSITIS
  申请人：The Scripps Research Institute

  公开号：EP3684180A1

  公开（公告）日：2020-07-29
• PHOSPHOLIPID NANOGEL FOR ENZYME STABILIZATION
  申请人：West Virginia University

  公开号：US20180251752A1

  公开（公告）日：2018-09-06

  Described herein are phospholipid nanogels that can contain a low concentration (less than about 250 μUnits/μL) of an exoglycosidase enzyme. Also described herein are systems and devices that can contain a phospholipid nanogel that can contain a low concentration (less than about 250 μUnits/μL) of an exoglycosidase enzyme. Also described herein are methods of using the phospholipid nanogels described herein and devices and systems that can contain a phospholipid nanogel described herein.