2-[2,3-bis[[(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoyl]oxy]propoxy-hydroxyphosphoryl]oxyethyl-trimethylazanium

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油磷脂
• 英文名称: 2-[2,3-bis[[(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoyl]oxy]propoxy-hydroxyphosphoryl]oxyethyl-trimethylazanium
• 化学式: C48H81NO8P+
• 分子量: 831.1
• InChiKey: LZLVZIFMYXDKCN-UEBVPGJCSA-O

计算性质

• 辛醇/水分配系数(LogP)：
  11.9
• 重原子数：
  58
• 可旋转键数：
  40
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  108
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• LIPID NANOPARTICLES
  申请人：ETHERNA IMMUNOTHERAPIES NV

  公开号：US20200345641A1

  公开（公告）日：2020-11-05

  The present invention relates to the field of lipid nanoparticles more specifically comprising an ionisable lipid, a phospholipid, a sterol, a PEG lipid and one or more nucleic acids. The LNP's of the present invention are characterized in having a minimal average diameter of about 140 nm, thereby inducing a more potent immune response. The present invention provides use of the LNPs for immunogenic delivery of nucleic acid molecules, specifically mRNA; thereby making them highly suitable for use in vaccines, such as for the treatment of cancer or infectious diseases. Finally, methods are provided for preparing such LNP's.
• COMPOUNDS AND COMPOSITIONS FOR INTRACELLULAR DELIVERY OF AGENTS
  申请人：ModernaTX, Inc.

  公开号：US20210161829A1

  公开（公告）日：2021-06-03

  The disclosure features amino lipids and compositions involving the same. Nanoparticle compositions include an amino lipid as well as additional lipids such as phospholipids, structural lipids, PEG lipids, or a combination thereof. Nanoparticle compositions further including therapeutic and/or prophylactic agents such as RNA are useful in the delivery of therapeutic and/or prophylactic agents to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.