3-(Acetyloxy)-2-hydroxypropoxy(2-(trimethylammonio)ethoxy)phosphinic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油磷脂
• 英文名称: 3-(Acetyloxy)-2-hydroxypropoxy(2-(trimethylammonio)ethoxy)phosphinic acid
• 英文别名: 2-[(3-acetyloxy-2-hydroxypropoxy)-hydroxyphosphoryl]oxyethyl-trimethylazanium
• 化学式: C10H23NO7P+
• 分子量: 300.27
• InChiKey: RYCNUMLMNKHWPZ-UHFFFAOYSA-O

计算性质

• 辛醇/水分配系数(LogP)：
  -1.7
• 重原子数：
  19
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  102
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• BIOMARKERS USEFUL FOR DIAGNOSING PROSTATE CANCER, AND METHODS THEREOF
  申请人：Ritchie Shawn

  公开号：US20090127454A1

  公开（公告）日：2009-05-21

  The present invention describes a method for predicting a health-state indicative of the presence of prostate cancer. The method measures the intensities of specific small biochemicals, called metabolites, in a blood sample from a patient with an undetermined health-state, and compares these intensities to the intensities observed in a population of healthy individuals and/or to the intensities previously observed in a population of confirmed prostate cancer-positive individuals. The method enables a practitioner to determine the probability that a screened patient is positive for prostate cancer.
• Chemosensory Receptor Ligand-Based Therapies
  申请人：Brown Martin R.

  公开号：US20130303466A1

  公开（公告）日：2013-11-14

  Provided herein are methods for treating conditions associated with a chemosensory receptor, including diabetes, obesity, and other metabolic diseases, disorders or conditions by administering a composition comprising a chemosensory receptor ligand. Also provided herein are chemosensory receptor ligand compositions and methods for the preparation thereof for use in the methods of the present invention.
• US8409794B2
  申请人：——

  公开号：US8409794B2

  公开（公告）日：2013-04-02
• [EN] BIOMARKERS FOR DIAGNOSING MULTIPLE SCLEROSIS, AND METHODS THEREOF<br/>[FR] BIOMARQUEURS ET MÉTHODES POUR DIAGNOSTIQUER LA SCLÉROSE EN PLAQUES
  申请人：PHENOMENOME DISCOVERIES INC

  公开号：WO2007137410A1

  公开（公告）日：2007-12-06

  [EN] The present invention describes methods for the diagnosis and differential diagnosis of the different forms of multiple sclerosis The methods measure the intensities of specific small molecules called metabolites in samples from patients with clinically diagnosed relapsmg-remittmg or primary-progressive forms of multiple sclerosis and compare these intensities to the intensities observed in a population of healthy individuals, thus identifying markers of multiple sclerosis A method is also provided for the differential diagnosis of subjects afflicted with relapsing- renitting multiple sclerosis from secondary-progressive multiple sclerosis.
  [FR] La présente invention concerne des méthodes pour le diagnostic et le diagnostic différentiel de différentes formes de sclérose en plaques. Les méthodes mesurent les intensités de petites molécules spécifiques appelées métabolites dans des échantillons provenant de patients pour lesquels on a diagnostiqué une forme clinique récidivante-rechutante ou une forme primaire progressive de sclérose en plaques et comparent ces intensités aux intensités observées dans une population d'individus sains, identifiant ainsi des marqueurs de sclérose en plaques. L'invention concerne aussi une méthode pour le diagnostic différentiel de sujets atteints de la sclérose en plaques récidivante-rechutante provenant de la sclérose en plaques secondaire progressive.