(7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z,26E)-13-acetyloxy-15,17,29-trihydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-26-[[(4-methylpiperazin-4-ium-1-yl)amino]methylidene]-6,23,27-trioxo-8,30-dioxa-24-azatetracyclo[23.3.1.14,7.05,28]triaconta-1(28),2,4,9,19,21,25(29)-heptaen-2-olate

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 大环内酰胺类
• 英文名称: (7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z,26E)-13-acetyloxy-15,17,29-trihydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-26-[[(4-methylpiperazin-4-ium-1-yl)amino]methylidene]-6,23,27-trioxo-8,30-dioxa-24-azatetracyclo[23.3.1.14,7.05,28]triaconta-1(28),2,4,9,19,21,25(29)-heptaen-2-olate
• 化学式: C₄₃H₅₈N₄O₁₂
• 分子量: 822.9
• InChiKey: FZYOVNIOYYPUPY-ZTWDQPHTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  59
• 可旋转键数：
  5
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  217
• 氢给体数：
  6
• 氢受体数：
  15

文献信息

• Multi-drug therapies for tuberculosis treatment
  申请人：THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

  公开号：US10576079B2

  公开（公告）日：2020-03-03

  The present invention is directed to methods of treating tuberculosis by providing a pharmaceutically effective amount of a combination of drug compounds.

  本发明涉及通过提供药用有效量的药物化合物组合来治疗结核病的方法。
• MULTI-DRUG THERAPIES FOR TUBERCULOSIS TREATMENT
  申请人：THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

  公开号：US20170333427A1

  公开（公告）日：2017-11-23

  The present invention is directed to methods of treating tuberculosis by providing a pharmaceutically effective amount of a combination of drug compounds.