2-amino-1-phenylaminopropane | 62733-56-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-amino-1-phenylaminopropane
• 英文别名: (2S)-1-N-phenylpropane-1,2-diamine
• CAS: 62733-56-6
• 化学式: C₉H₁₄N₂
• 分子量: 150.224
• InChiKey: RNQLRGJXXXBNMK-QMMMGPOBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  38
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-tosylamino-1-phenylaminopropane 在 硫酸 作用下， 反应 2.0h， 以97%的产率得到2-amino-1-phenylaminopropane
  参考文献：
  名称：

  Synthesis of β-amino-α-trifluoromethyl-α-amino acids exhibiting intramolecular interaction of CF3 with NHβ

  摘要：

  We prepared beta-amino-alpha-trifluoromethyl-alpha-amino acids through ring-opening reaction of N-tosyl-2-tri-fluoromethy1-2-ethoxycarbonylaziridine with aromatic and benzylic amines, and investigated the intramolecular interaction between the trifluoromethyl (CF3) group at the alpha-position and the NH group at the beta-position (NH beta), NMR UV/vis, and circular dichroism measurements indicated that the conformation of these compounds is fixed by intramolecular interaction of CF3 with NH beta to form a six-membered ring. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2014.10.107

文献信息

• Fourneau, Bulletin de la Societe Chimique de France, 1944, vol. <5>11, p. 141,148
  作者：Fourneau

  DOI：——

  日期：——
• [EN] METHODS FOR TREATING DISEASES ASSOCIATED WITH THE MODULATION OF SERCA<br/>[FR] PROCÉDÉS DE TRAITEMENT DE MALADIES ASSOCIÉES À LA MODULATION DE SERCA
  申请人：CELLADON CORP

  公开号：WO2010088450A2

  公开（公告）日：2010-08-05

  Provided herein are compounds, compositions, and methods for treating or ameliorating diseases associated with the modulation of SERCA.
• Synthesis of β-amino-α-trifluoromethyl-α-amino acids exhibiting intramolecular interaction of CF3 with NHβ
  作者：Minoru Waki、Toshimasa Katagiri、Kenji Matsuno、Hiroyuki Miyachi

  DOI：10.1016/j.tetlet.2014.10.107

  日期：2014.12

  We prepared beta-amino-alpha-trifluoromethyl-alpha-amino acids through ring-opening reaction of N-tosyl-2-tri-fluoromethy1-2-ethoxycarbonylaziridine with aromatic and benzylic amines, and investigated the intramolecular interaction between the trifluoromethyl (CF3) group at the alpha-position and the NH group at the beta-position (NH beta), NMR UV/vis, and circular dichroism measurements indicated that the conformation of these compounds is fixed by intramolecular interaction of CF3 with NH beta to form a six-membered ring. (C) 2014 Elsevier Ltd. All rights reserved.