3-((5-(dimethylamino)naphthalene)-1-sulfonamido)propyl 4-methylbenzenesulfonate | 1026504-95-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 3-((5-(dimethylamino)naphthalene)-1-sulfonamido)propyl 4-methylbenzenesulfonate
• 英文别名: 3-[[5-(Dimethylamino)naphthalen-1-yl]sulfonylamino]propyl 4-methylbenzenesulfonate
• CAS: 1026504-95-9
• 化学式: C₂₂H₂₆N₂O₅S₂
• 分子量: 462.591
• InChiKey: LBRGMVIEAHSAHU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  31
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  110
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  3-((5-(dimethylamino)naphthalene)-1-sulfonamido)propyl 4-methylbenzenesulfonate 在 亚硝酸 、 二异丁基氢化铝 作用下， 以 甲醇 、 正己烷 、 二氯甲烷 、 水 、 丙酮 为溶剂， 生成 5-(dimethylamino)-N-(3-nitrososulfanylpropyl)naphthalene-1-sulfonamide
  参考文献：
  名称：

  Fluorophore-Labeled S-Nitrosothiols

  摘要：

  A series of fluorophore-labeled S-nitrosothiols were synthesized, and their fluorescence enhancements upon removal of the nitroso (NO) group were evaluated either by transnitrosation or by photolysis. It was shown that, with a suitable alkyl linker, the fluorescence intensity of dansyl-labeled S-nitrosothiols could be enhanced up to 30-fold. The observed fluorescence enhancement was attributed to the intramolecular energy transfer from fluorophore to the SNO moiety. Ab initio density functional theory (DFT) calculations indicated that the "overlap" between the SNO moiety and the dansyl ring is favored because of their stabilizing interaction, which was in turn affected by both the length of the alkyl linker and the rigidity of the sulfonamide unit. In addition, one of the dansyl-labeled S-nitrosothiols was used to explore the kinetics of S-nitrosothiol/thiol transnitrosation and was evaluated as a fluorescence probe of S-nitrosothiol-bound NO transfer in human umbilical vein endothelial cells.

  DOI：

  10.1021/jo015658p
• 作为产物：
  描述：

  丹酰氯 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 生成 3-((5-(dimethylamino)naphthalene)-1-sulfonamido)propyl 4-methylbenzenesulfonate
  参考文献：
  名称：

  Fluorophore-Labeled S-Nitrosothiols

  摘要：

  A series of fluorophore-labeled S-nitrosothiols were synthesized, and their fluorescence enhancements upon removal of the nitroso (NO) group were evaluated either by transnitrosation or by photolysis. It was shown that, with a suitable alkyl linker, the fluorescence intensity of dansyl-labeled S-nitrosothiols could be enhanced up to 30-fold. The observed fluorescence enhancement was attributed to the intramolecular energy transfer from fluorophore to the SNO moiety. Ab initio density functional theory (DFT) calculations indicated that the "overlap" between the SNO moiety and the dansyl ring is favored because of their stabilizing interaction, which was in turn affected by both the length of the alkyl linker and the rigidity of the sulfonamide unit. In addition, one of the dansyl-labeled S-nitrosothiols was used to explore the kinetics of S-nitrosothiol/thiol transnitrosation and was evaluated as a fluorescence probe of S-nitrosothiol-bound NO transfer in human umbilical vein endothelial cells.

  DOI：

  10.1021/jo015658p

文献信息

• Astemizole-based turn-on fluorescent probes for imaging hERG potassium channel
  作者：Xiaomeng Zhang、Tingting Liu、Beilei Wang、Yuqi Gao、Pan Liu、Minyong Li、Lupei Du

  DOI：10.1039/c8md00562a

  日期：——

  Based on the scaffold of astemizole, three novel turn-on fluorescent probes (N1–N3) for human ether-a-go-go-related gene (hERG) potassium channel were developed herein.

  基于astemizole的支架，本研究开发了三种新型用于人类ether-a-go-go相关基因（hERG）钾通道的开启型荧光探针（N1-N3）。
• Fluorophore-Labeled <i>S</i>-Nitrosothiols
  作者：Xinchao Chen、Zhong Wen、Ming Xian、Kun Wang、Niroshan Ramachandran、Xiaoping Tang、H. Bernhard Schlegel、Bulent Mutus、Peng George Wang

  DOI：10.1021/jo015658p

  日期：2001.9.1

  A series of fluorophore-labeled S-nitrosothiols were synthesized, and their fluorescence enhancements upon removal of the nitroso (NO) group were evaluated either by transnitrosation or by photolysis. It was shown that, with a suitable alkyl linker, the fluorescence intensity of dansyl-labeled S-nitrosothiols could be enhanced up to 30-fold. The observed fluorescence enhancement was attributed to the intramolecular energy transfer from fluorophore to the SNO moiety. Ab initio density functional theory (DFT) calculations indicated that the "overlap" between the SNO moiety and the dansyl ring is favored because of their stabilizing interaction, which was in turn affected by both the length of the alkyl linker and the rigidity of the sulfonamide unit. In addition, one of the dansyl-labeled S-nitrosothiols was used to explore the kinetics of S-nitrosothiol/thiol transnitrosation and was evaluated as a fluorescence probe of S-nitrosothiol-bound NO transfer in human umbilical vein endothelial cells.