2-naphthalen-1-yl-5-(propane-2-sulfonyl)thiophene | 1313758-62-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-naphthalen-1-yl-5-(propane-2-sulfonyl)thiophene
• 英文别名: 2-Naphthalen-1-yl-5-propan-2-ylsulfonylthiophene
• CAS: 1313758-62-1
• 化学式: C₁₇H₁₆O₂S₂
• 分子量: 316.445
• InChiKey: MIGUZQVGIBVROZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  70.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1-溴代萘 、 2-(propane-2-sulfonyl)thiophene 在 potassium acetate 、 palladium diacetate 作用下， 以 N,N-二甲基乙酰胺 为溶剂， 反应 16.0h， 以77%的产率得到2-naphthalen-1-yl-5-(propane-2-sulfonyl)thiophene
  参考文献：
  名称：

  Palladium-Catalyzed Direct Arylation of Thiophenes Bearing SO₂R Substituents

  摘要：

  The palladium-catalyzed direct arylation of SO2R-substituted thiophene derivatives was found to proceed regioselectively at CS and in high yields using a variety of aryl bromides and as low as 0.5-0.1 mol % of phosphine-free Pd(OAc)(2) as the catalyst. For these reactions, sulfonyls, sulfonamides, or even a sulfonic ester as the thiophene substituents were successfully employed.

  DOI：

  10.1021/jo200918n

文献信息

• Palladium-Catalyzed Direct Arylation of Thiophenes Bearing SO₂R Substituents
  作者：Charles Beromeo Bheeter、Jitendra K. Bera、Henri Doucet

  DOI：10.1021/jo200918n

  日期：2011.8.5

  The palladium-catalyzed direct arylation of SO2R-substituted thiophene derivatives was found to proceed regioselectively at CS and in high yields using a variety of aryl bromides and as low as 0.5-0.1 mol % of phosphine-free Pd(OAc)(2) as the catalyst. For these reactions, sulfonyls, sulfonamides, or even a sulfonic ester as the thiophene substituents were successfully employed.