2-{[(3-chloro-5-(trifluoromethyl)pyridin-2-yl)imino]methyl}-phenol | 303090-94-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 2-{[(3-chloro-5-(trifluoromethyl)pyridin-2-yl)imino]methyl}-phenol
• 英文别名: 2-({[3-Chloro-5-(trifluoromethyl)-2-pyridinyl]imino}methyl)benzenol；2-[[3-chloro-5-(trifluoromethyl)pyridin-2-yl]iminomethyl]phenol
• CAS: 303090-94-0
• 化学式: C₁₃H₈ClF₃N₂O
• 分子量: 300.668
• InChiKey: BMYHQEKGIRCDMV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  45.5
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  邻甲基苄醇 、 2-氨基-3-氯-5-三氟甲基吡啶 反应 0.07h， 以76%的产率得到2-{[(3-chloro-5-(trifluoromethyl)pyridin-2-yl)imino]methyl}-phenol
  参考文献：
  名称：

  SOLVENT-FREE SYNTHESES OF SALICYLALDIMINES ASSISTED BY MICROWAVE IRRADIATION

  摘要：

  A microwave-assisted condensation of salicylaldehyde and aryl amines without solvent were efficiently performed to form a series of salicylaldimines in high yields, which were confirmed by IR, H-1 NMR, C-13 NMR and elemental analyses. The microwave-assisted condensation provided a convenient environmental-friendship methodology for syntheses of Schiff-base in organic syntheses.

  DOI：

  10.1081/scc-120006012

文献信息

• SOLVENT-FREE SYNTHESES OF SALICYLALDIMINES ASSISTED BY MICROWAVE IRRADIATION
  作者：Haijian Yang、Wen-Hua Sun、Zilong Li、Leyong Wang

  DOI：10.1081/scc-120006012

  日期：2002.1

  A microwave-assisted condensation of salicylaldehyde and aryl amines without solvent were efficiently performed to form a series of salicylaldimines in high yields, which were confirmed by IR, H-1 NMR, C-13 NMR and elemental analyses. The microwave-assisted condensation provided a convenient environmental-friendship methodology for syntheses of Schiff-base in organic syntheses.