8-Bromo-1,2,3,4-tetrahydro-naphthalen-1-ylamine | 348627-52-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: 8-Bromo-1,2,3,4-tetrahydro-naphthalen-1-ylamine
• 英文别名: 8-Bromo-1,2,3,4-tetrahydronaphthalen-1-amine
• CAS: 348627-52-1
• 化学式: C₁₀H₁₂BrN
• 分子量: 226.116
• InChiKey: ZSWFVACTSWMVQG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-氨基-4-氯-5-硝基-6-羟基嘧啶 、 8-Bromo-1,2,3,4-tetrahydro-naphthalen-1-ylamine 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 生成 2-Amino-6-(8-bromo-1,2,3,4-tetrahydro-naphthalen-1-ylamino)-5-nitro-3H-pyrimidin-4-one
  参考文献：
  名称：

  Synthesis and structure–activity relationships of guanine analogues as phosphodiesterase 7 (PDE7) inhibitors

  摘要：

  The synthesis of a novel series of guanine analogues is reported. The compounds have been assessed in vitro and some analogues have been found to be inhibitors of phosphodiesterase type 7 (PDE7). (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(01)00125-1

文献信息

• METHODS FOR MAKING QUINOLINYLDIAMINES
  申请人：ExxonMobil Chemical Patents Inc.

  公开号：US20200071344A1

  公开（公告）日：2020-03-05

  The present disclosure provides methods for making quinolinyldiamine products from quinolinyl starting materials. In addition, the quinolinyldiamines can be used as ligands or ligand precursors for catalysts, e.g. for use in olefin polymerization.

  本公开提供了一种从喹啉基起始材料制备喹啉二胺产品的方法。此外，这些喹啉二胺可以用作配体或催化剂的前体，例如用于烯烃聚合反应。
• Methods for making quinolinyldiamines
  申请人：ExxonMobil Chemical Patents Inc.

  公开号：US10807997B2

  公开（公告）日：2020-10-20

  The present disclosure provides methods for making quinolinyldiamine products from quinolinyl starting materials. In addition, the quinolinyldiamines can be used as ligands or ligand precursors for catalysts, e.g. for use in olefin polymerization.

  本公开提供了从喹啉基起始材料制取喹啉基二胺产品的方法。此外，喹啉基二胺还可用作催化剂的配体或配体前体，例如用于烯烃聚合。
• [EN] METHODS FOR MAKING QUINOLINYLDIAMINES<br/>[FR] PROCÉDÉS DE PRODUCTION DE QUINOLINYLDIAMINES
  申请人：EXXONMOBIL CHEMICAL PATENTS INC

  公开号：WO2020046794A1

  公开（公告）日：2020-03-05

  The present disclosure provides methods for making quinolinyldiamine products from quinolinyl starting materials. In addition, the quinolinyldiamines can be used as ligands or ligand precursors for catalysts, e.g. for use in olefin polymerization.
• Synthesis and structure–activity relationships of guanine analogues as phosphodiesterase 7 (PDE7) inhibitors
  作者：Matthew J Barnes、Nicola Cooper、Richard J Davenport、Hazel J Dyke、Fiona P Galleway、Frances C.A Galvin、Lewis Gowers、Alan F Haughan、Christopher Lowe、Johannes W.G Meissner、John G Montana、Trevor Morgan、C.Louise Picken、Robert J Watson

  DOI：10.1016/s0960-894x(01)00125-1

  日期：2001.4

  The synthesis of a novel series of guanine analogues is reported. The compounds have been assessed in vitro and some analogues have been found to be inhibitors of phosphodiesterase type 7 (PDE7). (C) 2001 Elsevier Science Ltd. All rights reserved.