Thiazinotrienomycin E

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 大环内酰胺类
• 英文名称: Thiazinotrienomycin E
• 英文别名: [(6E,8E,10E,16Z)-15,28-dihydroxy-5-methoxy-14,16-dimethyl-3,24-dioxo-22-thia-2,25-diazatricyclo[18.7.1.021,26]octacosa-1(27),6,8,10,16,20(28),21(26)-heptaen-13-yl] 2-(cyclohexanecarbonylamino)propanoate
• 化学式: C₃₈H₅₁N₃O₈S
• 分子量: 709.904
• InChiKey: FZQITFWYBUDNRH-MHVOAVBDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  50
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  189
• 氢给体数：
  5
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  重氮甲烷 、 Thiazinotrienomycin E 以 乙醚 为溶剂， 反应 2.0h， 生成 2-(Cyclohexanecarbonyl-amino)-propionic acid (6E,8E,10E,16Z)-15-hydroxy-5,28-dimethoxy-14,16-dimethyl-3,24-dioxo-22-thia-2,25-diaza-tricyclo[18.7.1.0^21,26]octacosa-1(28),6,8,10,16,20,26-heptaen-13-yl ester
  参考文献：
  名称：

  Thiazinotrienomycins, New Ansamycin Group Antibiotics.

  摘要：

  New triene-ansamycins designated thiazinotrienomycins A, B, C, D and E were isolated from culture broth of Streptomyces sp. MJ672-m3 for their activities against cervical cancer cell lines. The structures and some biological and biochemical properties of the antibiotics were determined.

  DOI：

  10.7164/antibiotics.48.471

文献信息

• Thiazinotrienomycins, New Ansamycin Group Antibiotics.
  作者：NOBUO HOSOKAWA、HIROSHI NAGANAWA、HIRONOBU IINUMA、MASA HAMADA、TOMIO TAKEUCHI、TOSHIE KANBE、MAKOTO HORI

  DOI：10.7164/antibiotics.48.471

  日期：——

  New triene-ansamycins designated thiazinotrienomycins A, B, C, D and E were isolated from culture broth of Streptomyces sp. MJ672-m3 for their activities against cervical cancer cell lines. The structures and some biological and biochemical properties of the antibiotics were determined.