bis(N,N-diisopropylamino)chlorophosphine | 93696-28-7

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: bis(N,N-diisopropylamino)chlorophosphine
• 英文别名: (N,N-diisopropylamino)chlorophosphine；diisopropylamino-chloro-phosphane；Chlor(diisopropylamino)phosphan；N-chlorophosphanyl-N-propan-2-ylpropan-2-amine
• CAS: 93696-28-7
• 化学式: C₆H₁₅ClNP
• 分子量: 167.619
• InChiKey: HQMBYXUPHJBVMF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  9
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  bis(N,N-diisopropylamino)chlorophosphine 在 四氮唑 、 三乙胺 作用下， 以 乙醚 、 二氯甲烷 为溶剂， 反应 1.0h， 生成 1,2-di-O-palmitoyl-sn-glycero-benzyloxy (N,N-diisopropylamino) phosphoramidite
  参考文献：
  名称：

  Synthesis of 1-O-(1,2-Di-O-palmitoyl-SN-glycero-3-phosphoryl)-2-O-α-D-mannopyranosyl-D-MYO-inositol: a fragment of mycobacterial phospholipids

  摘要：

  DOI：

  10.1016/s0040-4020(01)81026-7
• 作为产物：
  描述：

  (i-Pr2N)-chloro(trimethylsilyl)phosphine 在 甲醇 作用下， 以 甲苯 、 正戊烷 为溶剂， 生成 bis(N,N-diisopropylamino)chlorophosphine
  参考文献：
  名称：

  Streubel, Rainer; Niecke, Edgar, Chemische Berichte, 1990, vol. 123, # 6, p. 1245 - 1251

  摘要：

  DOI：

文献信息

• [EN] NUCLEIC ACID-POLYPEPTIDE COMPOSITIONS AND USES THEREOF<br/>[FR] COMPOSITIONS D'ACIDE NUCLÉIQUE-POLYPEPTIDE ET UTILISATIONS DE CELLES-CI
  申请人：AVIDITY BIOSCIENCES INC

  公开号：WO2020247782A1

  公开（公告）日：2020-12-10

  Disclosed herein are compositions and pharmaceutical formulations that comprise a binding moiety conjugated to a modified polynucleic acid molecule and a polymer. Also described herein include methods for treating a cancer which utilize a composition or a pharmaceutical formulation comprising a binding moiety conjugated to a polynucleic acid molecule and a polymer.

  本文披露了包括与修饰的多核苷酸分子和聚合物结合的结合基团的组合物和药物配方。本文还描述了利用包括结合基团与多核苷酸分子和聚合物结合的组合物或药物配方治疗癌症的方法。
• An example of cheletropic reactivity of a methylene phosphane
  作者：Hansjörg Grützmacher、Hans Pritzkow、Martin Stephan

  DOI：10.1016/s0040-4020(01)82019-6

  日期：1990.1

  In the reaction of a 2-phosphonio-1-phospha-1-alkene with tetra-chloro-orthobenzoquinone, a [4+1]cycloaddition is observed. In the presence of a Lewis acid, however, [4+2]cycloaddition takes place

  在2-膦基-1-膦-1-烯与四氯-邻苯并醌的反应中，观察到[4 + 1]环加成。然而，在路易斯酸的存在下，发生[4 + 2]环加成
• Compositions and methods of synthesis and use of novel nucleic acid structures
  申请人：Eritja Ramon

  公开号：US20060008813A1

  公开（公告）日：2006-01-12

  The present invention is directed to a method to produce 8-amino-2′deoxyadenosine by treating 8-azido-2′deoxyadenosine with an aqueous solution of methylamine or dimethylamine.

  本发明涉及一种通过将8-偶氮基-2'-脱氧腺苷与甲胺或二甲胺的水溶液处理来制备8-氨基-2'-脱氧腺苷的方法。
• Novel nucleic acid base pair
  申请人：Hirao Ichiro

  公开号：US20050191689A1

  公开（公告）日：2005-09-01

  A novel artificial nucleic acid base pair which is obtained by forming a selective base pair by introducing a group having steric hindrance (preferably a group having steric hindrance and static repulsion and a stacking effect) and can be recognized by a polymerase such as DNA polymerase; a novel artificial gene; and a method of designing nucleic acid bases so as to form a selective base pair with the use of steric hindrance, static repulsion and stacking effect at the base moiety of the nucleic acid. An artificial nucleic acid comprising these bases; a process for producing the same; a codon containing the same; a nucleic acid molecule containing the same; a process for producing a non-natural gene by using the same; a process for producing a novel protein by using the above nucleic acid molecule or non-natural gene, and the like.

  一种新的人工核酸碱基对，通过引入具有立体位阻的基团（优选具有立体位阻和静电斥力以及堆积效应的基团），形成选择性碱基对，并能被DNA聚合酶等聚合酶识别；一种新的人工基因；以及一种设计核酸碱基的方法，以便利用核酸的碱基部分的立体位阻、静电斥力和堆积效应形成选择性碱基对。包括这些碱基的人工核酸；生产该核酸的过程；含有该核酸的密码子；含有该核酸的核酸分子；利用该核酸分子或非天然基因生产非天然基因的过程；利用上述核酸分子或非天然基因生产新型蛋白质的过程等。
• 3'-End Nucleoside Unit Comprising Phosphoramidite
  申请人：Sekine Mitsuo

  公开号：US20080039620A1

  公开（公告）日：2008-02-14

  The purpose of the present invention is therefore to provide a method for binding a 3′-end nucleoside unit comprising any base to a hydroxyl group on a solid-phase support under completely the same condition as in DNA chain elongation reaction. The present invention relates to a 3′-end nucleoside unit comprising phosphoramidite that is a compound represented by the following formula: (N)—O—(R1)Si(R2)-(C 6 H 4 )—(CH 2 ) n -O—P(OR3)N(R4)(R5)  (I) wherein (N) represents any nucleoside or its derivative, each of R1, R2, R4 and R5 is an alkyl or aryl group, R3 is a phosphate-protecting group, and n is an integer of from 1 to 5; a solid-phase support having said 3′-end nucleoside unit; and a method for the synthesis of a nucleic acid oligomer with the use of said solid-phase support.

  本发明的目的是提供一种方法，以完全相同的条件将包含任何碱基的3'-末端核苷酸单元与固相支持体上的羟基结合，就像DNA链延伸反应一样。本发明涉及一种包含磷酰胺酯的3'-末端核苷酸单元，该化合物由以下公式表示：(N)-O-(R1)Si(R2)-(C6H4)-(CH2)n-O-P(OR3)N(R4)(R5) (I)，其中(N)代表任何核苷酸或其衍生物，R1、R2、R4和R5各自是烷基或芳基，R3是磷酸保护基，n为1至5的整数；具有所述3'-末端核苷酸单元的固相支持体；以及使用所述固相支持体合成核酸寡聚体的方法。