抗生素是一类用于治疗细菌感染的化合物,广泛应用于临床医学和兽医领域。除了青霉素、头孢菌素等广为人知的抗生素外,还有多种其它类型的抗生素在临床上发挥重要作用。
大环内酯类抗生素大环内酯类抗生素是由链霉菌产生的次级代谢产物,代表药物包括红霉素、阿奇霉素和克拉霉素。这类抗生素通过与细菌核糖体50S亚基结合,抑制蛋白质合成,从而起到抗菌作用。它们广泛用于治疗呼吸道感染、皮肤软组织感染以及某些性传播疾病。
氨基糖苷类抗生素氨基糖苷类抗生素由链霉菌和小单胞菌产生,代表药物有庆大霉素、阿米卡星等。这类抗生素通过与细菌核糖体30S亚基结合,干扰蛋白质合成过程中的氨酰-tRNA的进入,导致错误氨基酸插入以及肽链过早终止。它们常用于治疗革兰氏阴性菌引起的严重感染。
四环素类抗生素四环素类抗生素是最早被发现并广泛使用的广谱抗生素之一,包括多西环素、米诺环素等。这类药物通过与细菌核糖体30S亚基结合,抑制蛋白质合成,并且能穿透革兰氏阴性和阳性菌的细胞壁。尽管它们具有广泛的抗菌谱和良好的口服生物利用度,但由于潜在的肝毒性、肾毒性和牙色素沉着等不良反应,在使用时需谨慎。
氟喹诺酮类抗生素氟喹诺酮类抗生素是一类人工合成的广谱抗菌药物,如氧氟沙星、左氧氟沙星。它们通过抑制细菌DNA旋转酶和拓扑异构酶IV,干扰DNA复制与重组过程。这类药物对多种革兰氏阳性和阴性菌有效,并且具有良好的口服吸收特性。
氯霉素类抗生素氯霉素是一类较早的广谱抗生素,主要适用于耐药性链球菌、某些厌氧菌和立克次体感染。然而由于其潜在的骨髓抑制作用(引起再生障碍性贫血),临床应用受到一定限制。
这些不同类型的抗生素各有特点,在治疗特定类型细菌感染时表现出不同的效果与副作用。因此,在使用抗生素时需要根据具体病情和细菌培养及药敏试验结果,合理选择药物种类和剂量,以达到最佳的治疗效果并减少不良反应的发生。
中文名称 | 英文名称 | CAS号 | 化学式 | 结构式图片 |
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—— | puromycin dihydrochloride | 58-58-2 | C22H29N7O5*2ClH |
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—— | 6,7β-epoxy-18α-hydroxy-16α,18β-dimethyl-10-phenyl-21,23-dioxa-[13]cytochalasa-13<i>t</i>,19<i>t</i>-diene-1,17,22-trione | 36011-19-5 | C28H33NO7 |
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—— | 5-Chloro-6-(7,8-epoxy-10-hydroxy-2-oxo-3,5-undecadienyl)-beta-resorcylic acid mu-lactone | 12772-57-5 | C18H17ClO6 |
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—— | [(3R,5R,6S,7R,8E,10R,11R,12Z,14E)-6-hydroxy-5,11,21-trimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate | 30562-34-6 | C29H40N2O9 |
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—— | Filimarisin | 11078-21-0 | C35H58O11 |
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—— | Monorden (B117339F008) | 12772-57-5 | C18H17ClO6 |
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—— | 4-hydroxy-N-[(5-nitro-2-furanyl)methylideneamino]benzamide | 965-52-6 | C12H9N3O5 |
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—— | Zorubicin hydrochloride | 36508-71-1 | C34H36ClN3O10 |
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—— | (4R,6R,8R,9E,11E)-16-chloro-17,19-dihydroxy-4-methyl-3,7-dioxatricyclo[13.4.0.06,8]nonadeca-1(15),9,11,16,18-pentaene-2,13-dione | 12772-57-5 | C18H17ClO6 |
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—— | 2-[(4E,6E)-7-cyano-8,16-dihydroxy-9,11,13,15-tetramethyl-18-oxo-1-oxacyclooctadeca-4,6-dien-2-yl]cyclopentane-1-carboxylic acid | 7184-60-3 | C28H43NO6 |
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—— | (2E,5S,6R,7S,9R,10E,12E,15R,16Z,18E)-17-ethyl-6-hydroxy-3,5,7,9,11,15-hexamethyl-19-[(2R,3R)-3-methyl-6-oxo-2,3-dihydropyran-2-yl]-8-oxononadeca-2,10,12,16,18-pentaenoic acid | 87081-35-4 | C33H48O6 |
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—— | ansamitocin P-3' | 66547-09-9 | C32H43ClN2O9 |
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—— | [(1R,2R,3Z,5R,7S,9Z,11R,12S,14S,15R,16S)-16-benzyl-5,12-dihydroxy-5,7,14-trimethyl-13-methylidene-18-oxo-17-azatricyclo[9.7.0.01,15]octadeca-3,9-dien-2-yl] acetate | 53760-19-3 | C30H39NO5 |
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—— | [(4E,6E,8S,9S,10E,12R,13R,14R,16S)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl] carbamate | 30562-34-6 | C29H40N2O9 |
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—— | (2E,5S,6R,7S,9R,10Z,12E,15R,16E,18E)-17-ethyl-6-hydroxy-3,5,7,9,11,15-hexamethyl-19-[(2S,3S)-3-methyl-6-oxo-2,3-dihydropyran-2-yl]-8-oxononadeca-2,10,12,16,18-pentaenoic acid | 87081-35-4 | C33H48O6 |
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—— | Radicicol, Humicola fuscoatra | 12772-57-5 | C18H17ClO6 |
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—— | Ammonium ionophore | 6833-84-7 | C40H64O12 |
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—— | sodium;(2S)-2-[(3R)-6-[[(2S,4R,5R,6R,7R)-2-[(5S)-5-[(3R)-5-[(3S,5R,6R)-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyloxan-2-yl]-3-methyloxolan-2-yl]-5-methyloxolan-2-yl]-7-methoxy-2,4,6-trimethyl-1,10-dioxaspiro[4.5]decan-9-yl]methyl]-3-methyloxan-2-yl]propanoate | 28643-80-3 | C40H67NaO11 |
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—— | But-2-enedioic acid;(4-ethenyl-3-hydroxy-2,4,7,14-tetramethyl-9-oxo-6-tricyclo[5.4.3.01,8]tetradecanyl) 2-[2-(diethylamino)ethylsulfanyl]acetate | 55297-96-6 | C4H4O4*C28H47NO4S |
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—— | N-[1-[4-(4-amino-5-hydroxy-6-methyloxan-2-yl)oxy-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-3,4-dihydro-1H-tetracen-2-yl]ethylideneamino]benzamide;hydrochloride | 36508-71-1 | C34H36ClN3O10 |
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—— | Pharmakon1600-01501105 | 58-58-2 | C22H30ClN7O5 |
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—— | Vulcamycin | 1476-53-5 | C31H36N2NaO11+ |
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—— | novobiocin sodium salt | 1476-53-5 | C31H36N2O11*Na |
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—— | sodium;4-[[7-[(3R,4S,5R)-4-carbamoyloxy-3-hydroxy-5-methoxy-6,6-dimethyloxan-2-yl]oxy-4-hydroxy-8-methyl-2-oxochromen-3-yl]carbamoyl]-2-(3-methylbut-2-enyl)phenolate | 1476-53-5 | C31H35N2NaO11 |
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—— | Albamycin;Cathomycin | 1476-53-5 | C31H35N2NaO11 |
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—— | sodium;4-[[7-[(2R,3S,4S,5R)-4-carbamoyloxy-3-hydroxy-5-methoxy-6,6-dimethyloxan-2-yl]oxy-4-hydroxy-8-methyl-2-oxochromen-3-yl]carbamoyl]-2-(3-methylbut-2-enyl)phenolate | 1476-53-5 | C31H35N2NaO11 |
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—— | (1R,3S,5R,8E,12R,14E,16E,18E,20E,24S,25R,26S)-22-[(2R,3S,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy-1,3,26-trihydroxy-12-methyl-10-oxo-6,11,28-trioxatricyclo[22.3.1.05,7]octacosa-8,14,16,18,20-pentaene-25-carboxylic acid | 7681-93-8 | C33H47NO13 |
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—— | (1R,3S,5R,7R,8E,12R,14E,16Z,18E,20E,22R,24S,25R,26S)-22-[(2R,3S,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy-1,3,26-trihydroxy-12-methyl-10-oxo-6,11,28-trioxatricyclo[22.3.1.05,7]octacosa-8,14,16,18,20-pentaene-25-carboxylic acid | 52882-37-8 | C33H47O13N |
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—— | (4Z,18Z,20Z)-22-ethyl-7,11,14,15-tetrahydroxy-6'-(2-hydroxypropyl)-5',6,8,10,12,14,16,28,29-nonamethylspiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2'-oxane]-3,3',9,13-tetrone | 11050-94-5 | C45H72O12 |
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—— | (2E,5S,6R,7S,9R,10E,12E,15R,16E,18E)-17-ethyl-6-hydroxy-3,5,7,9,11,15-hexamethyl-19-[(2S,3S)-3-methyl-6-oxo-2,3-dihydropyran-2-yl]-8-oxononadeca-2,10,12,16,18-pentaenoic acid | 87081-35-4 | C33H48O6 |
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—— | (1R,3S,5R,7R,8E,12R,14E,16E,18E,20E,22R,24S,25R,26S)-22-[(2S,3R,4R,5R,6S)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy-1,3,26-trihydroxy-12-methyl-10-oxo-6,11,28-trioxatricyclo[22.3.1.05,7]octacosa-8,14,16,18,20-pentaene-25-carboxylic acid | 7681-93-8 | C33H47O13N |
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—— | (2S,3S,4S,6S)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8,10,12,14,19,21,23,25,27-nonaen-16-one | 62996-74-1 | C28H26N4O3 |
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—— | Indolocarbazole nitrogen derivative | 62996-74-1 | C28H26N4O3 |
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—— | (RA)/17-(allylamino)-17-demethoxygeldanamycin | 12772-57-5 | C18H17ClO6 |
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—— | Furasol hydrochloride | 3759-92-0 | C13H16ClN4O6- |
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—— | Voreloxin | 1393-48-2 | C72H85N19O18S5 |
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—— | (1S,2S,3Z,7R,11E,13R,15R)-2,15-dihydroxy-7-methyl-6-oxabicyclo[11.3.0]hexadeca-3,11-dien-5-one | 20350-15-6 | C16H24O4 |
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—— | (4R,6S,8S,9E,11Z)-16-chloro-17,19-dihydroxy-4-methyl-3,7-dioxatricyclo[13.4.0.06,8]nonadeca-1(15),9,11,16,18-pentaene-2,13-dione | 12772-57-5 | C18H17ClO6 |
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—— | (2E,4E,6E,8E)-10-[[(3R,4S,5S,6R)-5-methoxy-4-[(2R,3S)-2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl]-1-oxaspiro[2.5]octan-6-yl]oxy]-10-oxodeca-2,4,6,8-tetraenoic acid | 23110-15-8 | C26H34O7 |
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—— | 1-methyl-1-nitroso-3-[(2R,4R,5S,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]urea | 18883-66-4 | C8H15N3O7 |
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—— | 6H-Oxireno[e][2]benzoxacyclotetradecin-6,12(7H)-dione, 8-chloro-1a,14,15,15a-tetrahydro-9,11-dihydroxy-14-methyl-, (1aR,2Z,4E,14R,15aR)- | 12772-57-5 | C18H17ClO6 |
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—— | (2S,3R,4R,5R,6S)-2-[(2R,3R,4S,5S,6R)-5-hydroxy-6-(hydroxymethyl)-2-[[(1S,2S,7S,10R,14S,15R,16S,17R,20S)-10,14,16,20-tetramethyl-22-azahexacyclo[12.10.0.02,11.05,10.015,23.017,22]tetracos-4-en-7-yl]oxy]-4-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-3-yl]oxy-6-methyloxane-3,4,5-triol | 20562-02-1 | C45H73NO15 |
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—— | N-[(2S)-4-amino-1-[[(2S,3R)-1-[[(2S)-4-amino-1-oxo-1-[[(3S,6S,9S,12S,15R,18R,21S)-6,9,18-tris(2-aminoethyl)-15-benzyl-3-[(1R)-1-hydroxyethyl]-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxobutan-2-yl]-6-methyloctanamide;sulfuric acid | 1405-20-5 | C56H100N16O17S |
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—— | Antibiotic AM-2282;STS;AM-2282 | 62996-74-1 | C28H26N4O3 |
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—— | [(4Z,6Z,8R,9R,10Z,12R,13S,14R,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl] carbamate | 30562-34-6 | C29H40N2O9 |
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—— | 2-[5-hydroxy-6-(hydroxymethyl)-2-[[(10R,14S)-10,14,16,20-tetramethyl-22-azahexacyclo[12.10.0.02,11.05,10.015,23.017,22]tetracos-4-en-7-yl]oxy]-4-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-3-yl]oxy-6-methyloxane-3,4,5-triol | 20562-02-1 | C45H73NO15 |
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—— | (2R,3R)-2,3-dihydroxybutanedioic acid;2-[(4R,5S,6S,7R,9R,11Z,13Z,15R,16R)-6-[(2R,3R,4R,5S,6R)-5-[(2S,4R,5S,6S)-4,5-dihydroxy-4,6-dimethyloxan-2-yl]oxy-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-16-ethyl-4-hydroxy-15-[[(2R,3R,4R,5R,6R)-5-hydroxy-3,4-dimethoxy-6-methyloxan-2-yl]oxymethyl]-5,9,13-trimethyl-2,10-dioxo-1-oxacyclohexadeca-11,13-dien-7-yl]acetaldehyde | 1405-54-5 | C50H83NO23 |
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—— | 6,11,28-Trioxatricyclo[22.3.1.05,7]octacosa-8,14,16,18,20-pentaene-25-carboxylic acid,22-[(3-amino-3,6-dideoxy-b-D-mannopyranosyl)oxy]-1,3,26-trihydroxy-12-methyl-10-oxo-,(1R,3S,5R,7R,8E,12R,14E,16E,18E,20E,22R,24S,25R,26S)- | 7681-93-8 | C33H47O13N |
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—— | (1S,5Z,7R,9S,11Z,13S,14S,16R,17S,18S,19S)-19-benzyl-7-hydroxy-7,9,16,17-tetramethyl-2,4,15-trioxa-20-azatetracyclo[11.8.0.01,18.014,16]henicosa-5,11-diene-3,8,21-trione | 36011-19-5 | C28H33NO7 |
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—— | (2S,3'R,4S,4'S,5'R,6R,6'R,7S,7aS)-4-[(2S,3R,5S,6R)-3-amino-2,6-dihydroxy-5-(methylamino)cyclohexyl]oxy-6'-[(1R)-1-amino-2-hydroxyethyl]-6-(hydroxymethyl)spiro[4,6,7,7a-tetrahydro-3aH-[1,3]dioxolo[4,5-c]pyran-2,2'-oxane]-3',4',5',7-tetrol | 31282-04-9 | C20H37N3O13 |
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