抗生素是一类用于治疗细菌感染的化合物,广泛应用于临床医学和兽医领域。除了青霉素、头孢菌素等广为人知的抗生素外,还有多种其它类型的抗生素在临床上发挥重要作用。
大环内酯类抗生素大环内酯类抗生素是由链霉菌产生的次级代谢产物,代表药物包括红霉素、阿奇霉素和克拉霉素。这类抗生素通过与细菌核糖体50S亚基结合,抑制蛋白质合成,从而起到抗菌作用。它们广泛用于治疗呼吸道感染、皮肤软组织感染以及某些性传播疾病。
氨基糖苷类抗生素氨基糖苷类抗生素由链霉菌和小单胞菌产生,代表药物有庆大霉素、阿米卡星等。这类抗生素通过与细菌核糖体30S亚基结合,干扰蛋白质合成过程中的氨酰-tRNA的进入,导致错误氨基酸插入以及肽链过早终止。它们常用于治疗革兰氏阴性菌引起的严重感染。
四环素类抗生素四环素类抗生素是最早被发现并广泛使用的广谱抗生素之一,包括多西环素、米诺环素等。这类药物通过与细菌核糖体30S亚基结合,抑制蛋白质合成,并且能穿透革兰氏阴性和阳性菌的细胞壁。尽管它们具有广泛的抗菌谱和良好的口服生物利用度,但由于潜在的肝毒性、肾毒性和牙色素沉着等不良反应,在使用时需谨慎。
氟喹诺酮类抗生素氟喹诺酮类抗生素是一类人工合成的广谱抗菌药物,如氧氟沙星、左氧氟沙星。它们通过抑制细菌DNA旋转酶和拓扑异构酶IV,干扰DNA复制与重组过程。这类药物对多种革兰氏阳性和阴性菌有效,并且具有良好的口服吸收特性。
氯霉素类抗生素氯霉素是一类较早的广谱抗生素,主要适用于耐药性链球菌、某些厌氧菌和立克次体感染。然而由于其潜在的骨髓抑制作用(引起再生障碍性贫血),临床应用受到一定限制。
这些不同类型的抗生素各有特点,在治疗特定类型细菌感染时表现出不同的效果与副作用。因此,在使用抗生素时需要根据具体病情和细菌培养及药敏试验结果,合理选择药物种类和剂量,以达到最佳的治疗效果并减少不良反应的发生。
中文名称 | 英文名称 | CAS号 | 化学式 | 结构式图片 |
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—— | Thiostrepton 1 | 1393-48-2 | C72H85N19O18S5 |
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—— | Natacyn (TN) | 7681-93-8 | C33H47NO13 |
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—— | (4R,6S,8R,9Z,11E)-16-chloro-17,19-dihydroxy-4-methyl-3,7-dioxatricyclo[13.4.0.06,8]nonadeca-1(15),9,11,16,18-pentaene-2,13-dione | 12772-57-5 | C18H17ClO6 |
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—— | pipemidic acid trihydrate | 72571-82-5 | C14H17N5O3*3H2O |
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—— | (1R,2R,3E,7S,11E,13R,15S)-2,15-dihydroxy-7-methyl-6-oxabicyclo[11.3.0]hexadeca-3,11-dien-5-one | 20350-15-6 | C16H24O4 |
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—— | hygromycin B | 31282-04-9 | C20H37N3O13 |
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—— | Amebacilin;NSC9168 | 23110-15-8 | C26H34O7 |
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—— | (5E)-PGB<sub>2</sub> | 13367-85-6 | C20H30O4 |
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—— | (E)-but-2-enedioic acid;(4-ethenyl-3-hydroxy-2,4,7,14-tetramethyl-9-oxo-6-tricyclo[5.4.3.01,8]tetradecanyl) 2-[2-(diethylamino)ethylsulfanyl]acetate | 55297-96-6 | C4H4O4*C28H47NO4S |
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—— | (3S,9R,12R,15S,18S,21R,24R,27S,30S,33R,36R)-6,18,30-trimethyl-3,9,12,15,21,24,27,33,36-nona(propan-2-yl)-1,7,13,19,25,31-hexaoxa-4,10,16,22,28,34-hexazacyclohexatriacontane-2,5,8,11,14,17,20,23,26,29,32,35-dodecone | 2001-95-8 | C54H90N6O18 |
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—— | Herbimycin | 70563-58-5 | C30H42N2O9 |
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—— | cinchonidine | 485-71-2 | C19H22N2O |
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—— | (2R,3R)-2,3-dihydroxybutanedioic acid;2-[(4R,5S,6S,7R,9R,15R,16R)-6-[(2R,3R,4R,5S,6R)-5-[(2S,4R,5S,6S)-4,5-dihydroxy-4,6-dimethyloxan-2-yl]oxy-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-16-ethyl-4-hydroxy-15-[[(2R,3R,4R,5R,6R)-5-hydroxy-3,4-dimethoxy-6-methyloxan-2-yl]oxymethyl]-5,9,13-trimethyl-2,10-dioxo-1-oxacyclohexadeca-11,13-dien-7-yl]acetaldehyde | 74610-55-2 | C50H83NO23 |
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—— | N-[3-[(3-amino-3-oxoprop-1-en-2-yl)amino]-3-oxoprop-1-en-2-yl]-2-[(8S,11Z,18R,25S,35R,59S)-37-butan-2-yl-18-(2,3-dihydroxybutan-2-yl)-11-ethylidene-59-hydroxy-31-(1-hydroxyethyl)-8-[(1R)-1-hydroxyethyl]-26,40,46-trimethyl-43-methylidene-6,9,16,23,28,38,41,44,47-nonaoxo-27-oxa-3,13,20,56-tetrathia-7,10,17,24,36,39,42,45,48,52,58,61,62,63,64-pentadecazanonacyclo[23.23.9.329,35.12,5.112,15.119,22.154,57.01,53.032,60]tetrahexaconta-2(64),4,12(63),19(62),21,29(61),30,32(60),33,51,54,57-dodecaen-51-yl]-1,3-thiazole-4-carboxamide | 1393-48-2 | C72H85N19O18S5 |
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—— | Thiostrepton from Streptomyces azureus | 1393-48-2 | C72H85N19O18S5 |
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—— | Fosfomycin disodium salt | 26016-99-9 | C3H5Na2O4P |
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—— | [(2R,3S,4R,6R)-6-[(2R,4R,5S,6R)-2-[(2S,3R,4S)-4-[(2S,3S,4E,6Z,9R,10S,11S,12R,13R,14E,16Z)-11-ethyl-10,12-dihydroxy-3,17-dimethoxy-7,9,13,15-tetramethyl-18-oxo-1-oxacyclooctadeca-4,6,14,16-tetraen-2-yl]-3-hydroxypentan-2-yl]-2-hydroxy-5-methyl-6-[(E)-prop-1-enyl]oxan-4-yl]oxy-4-hydroxy-2-methyloxan-3-yl] carbamate | 80890-47-7 | C46H75NO14 |
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—— | [(4E,8R,10Z,12R,13S,14R,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl] carbamate | 30562-34-6 | C29H40N2O9 |
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—— | [(2S,3R,4S,6S)-6-[(2S,4S,5R,6S)-2-[(2R,3S,4R)-4-[(2S,3R,6E,9S,10S,12R,13S,14E,16Z)-11-ethyl-10,12-dihydroxy-3,17-dimethoxy-7,9,13,15-tetramethyl-18-oxo-1-oxacyclooctadeca-4,6,14,16-tetraen-2-yl]-3-hydroxypentan-2-yl]-2-hydroxy-5-methyl-6-[(E)-prop-1-enyl]oxan-4-yl]oxy-4-hydroxy-2-methyloxan-3-yl] carbamate | 80890-47-7 | C46H75NO14 |
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—— | 2-(7-Cyano-8,16-dihydroxy-9,11,13,15-tetramethyl-18-oxooxacyclooctadeca-4,6-dien-2-yl)cyclopentanecarboxylic acid | 7184-60-3 | C28H43NO6 |
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—— | 5-(Morpholin-4-ylmethyl)-3-[(Z)-(5-nitrofuran-2-yl)methylideneamino]-1,3-oxazolidin-2-one;hydrochloride | 3759-92-0 | C13H17ClN4O6 |
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—— | (E)-but-2-enedioic acid;[(2R,3S,4S,6R,8S,14R)-4-ethenyl-3-hydroxy-2,4,7,14-tetramethyl-9-oxo-6-tricyclo[5.4.3.01,8]tetradecanyl] 2-[2-(diethylamino)ethylsulfanyl]acetate | 55297-96-6 | C32H51NO8S |
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—— | [(4E,6Z,8R,9R,10E,12S,13R,14S,16R)-13-Hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl] carbamate | 30562-34-6 | C29H40N2O9 |
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—— | [(4Z,6E,10E)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl] carbamate | 30562-34-6 | C29H40N2O9 |
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—— | [6-[(2R,4S,5S,6R)-2-[(2S,3R,4S)-4-[(2R,3S,4E,6E,9R,10S,11S,12R,13R,14E,16Z)-11-ethyl-10,12-dihydroxy-3,17-dimethoxy-7,9,13,15-tetramethyl-18-oxo-1-oxacyclooctadeca-4,6,14,16-tetraen-2-yl]-3-hydroxypentan-2-yl]-2-hydroxy-5-methyl-6-[(E)-prop-1-enyl]oxan-4-yl]oxy-4-hydroxy-2-methyloxan-3-yl] carbamate | 80890-47-7 | C46H75NO14 |
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—— | (1r,2r)-2-[(2s,4e,6e,8r,9s,11r,13s,15s,16s)-7-Cyano-8,16-Dihydroxy-9,11,13,15-Tetramethyl-18-Oxooxacyclooctadeca-4,6-Dien-2-Yl]cyclopentanecarboxylic Acid | 7184-60-3 | C28H43NO6 |
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—— | sodium;(2R)-2-[(3S,6R)-6-[[(2S,4R,5R,6R,7R,9R)-2-[(5S)-5-[(2R,3S,5R)-5-[(2S,3S,5R,6R)-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyloxan-2-yl]-3-methyloxolan-2-yl]-5-methyloxolan-2-yl]-7-methoxy-2,4,6-trimethyl-1,10-dioxaspiro[4.5]decan-9-yl]methyl]-3-methyloxan-2-yl]propanoate | 28643-80-3 | C40H67NaO11 |
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—— | (5R)-5-(morpholin-4-ylmethyl)-3-[(Z)-(5-nitrofuran-2-yl)methylideneamino]-1,3-oxazolidin-2-one | 139-91-3 | C13H16N4O6 |
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—— | (17E,19E,21E,23E,25E)-4,6,8,10,12,14,16,27-octahydroxy-3-(1-hydroxyhexyl)-17,28-dimethyl-1-oxacyclooctacosa-17,19,21,23,25-pentaen-2-one | 480-49-9 | C35H58O11 |
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—— | Cytochalasin H | 53760-19-3 | C30H39NO5 |
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—— | 2-[5-Hydroxy-6-(hydroxymethyl)-2-[(10,14,16,20-tetramethyl-22-azahexacyclo[12.10.0.02,11.05,10.015,23.017,22]tetracos-4-en-7-yl)oxy]-4-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-3-yl]oxy-6-methyloxane-3,4,5-triol;chloride | 51938-42-2 | C45H73ClNO15- |
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—— | (+)-geldanamycin | 30562-34-6 | C29H40N2O9 |
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—— | Cytochalasin B-CASMI2016 Category 1-Challenge 3 | 14930-96-2 | C29H37NO5 |
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—— | ansamitocin P 3' | 66547-09-9 | C32H43ClN2O9 |
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—— | 22-[(2R,3S,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy-1,3,26-trihydroxy-12-methyl-10-oxo-6,11,28-trioxatricyclo[22.3.1.05,7]octacosa-8,14,16,18,20-pentaene-25-carboxylic acid | 7681-93-8 | C33H47O13N |
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—— | carbamic acid [(3R,5S,6R,7S,10S,11S)-6-hydroxy-5,11,21-trimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] ester | 30562-34-6 | C29H40N2O9 |
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—— | Azithromycin hydrate | 117772-70-0 | C38H76N2O14 |
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—— | (1S,3Z,7R,11E,13R,15R)-2,15-dihydroxy-7-methyl-6-oxabicyclo[11.3.0]hexadeca-3,11-dien-5-one | 20350-15-6 | C16H24O4 |
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—— | (1R,2R,3E,7S,13S,15S)-2,15-dihydroxy-7-methyl-6-oxabicyclo[11.3.0]hexadeca-3,11-dien-5-one | 20350-15-6 | C16H24O4 |
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—— | (1S,2S)-2-[(2R,4Z,6E,8S,9R,13R,15R,16R)-7-cyano-8,16-dihydroxy-9,11,13,15-tetramethyl-18-oxo-1-oxacyclooctadeca-4,6-dien-2-yl]cyclopentane-1-carboxylic acid | 7184-60-3 | C28H43NO6 |
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—— | Priomicina | 26016-99-9 | C3H7NaO4P+ |
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—— | (1S,4E,5'R,6R,6'R,7S,8R,10S,11S,12R,14R,15R,16S,18E,20E,22S,25S,27R,28R,29S)-22-ethyl-7,11,14,15-tetrahydroxy-6'-[(2S)-2-hydroxypropyl]-5',6,8,10,12,14,16,28,29-nonamethylspiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2'-oxane]-3,3',9,13-tetrone | 11050-94-5 | C45H72O12 |
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—— | [(4E,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl] carbamate | 30562-34-6 | C29H40N2O9 |
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—— | (3aS,4S,5'R,6R,6'R,7aS)-4-[(1R,6R)-3-amino-2,6-dihydroxy-5-(methylamino)cyclohexyl]oxy-6'-[(1S)-1-amino-2-hydroxyethyl]-6-(hydroxymethyl)spiro[4,6,7,7a-tetrahydro-3aH-[1,3]dioxolo[4,5-c]pyran-2,2'-oxane]-3',4',5',7-tetrol | 31282-04-9 | C20H37N3O13 |
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—— | (4R,6R,8R,11E)-16-chloro-17,19-dihydroxy-4-methyl-3,7-dioxatricyclo[13.4.0.06,8]nonadeca-1(15),9,11,16,18-pentaene-2,13-dione | 12772-57-5 | C18H17ClO6 |
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—— | [(6E,9S,13R,14S)-13-hydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl] carbamate | 30562-34-6 | C29H40N2O9 |
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—— | (2R,3S,4S,5S,6R)-2-[(2R,3R,4S,5S,6R)-5-hydroxy-6-(hydroxymethyl)-2-[[(1S,2S,7S,10R,11S,14S,15R,16S,17S,20S,23S)-10,14,16,20-tetramethyl-22-azahexacyclo[12.10.0.02,11.05,10.015,23.017,22]tetracos-4-en-7-yl]oxy]-4-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-3-yl]oxy-6-methyloxane-3,4,5-triol | 51938-42-2 | C45H73NO15 |
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—— | Natamycin (Pimaricin) | 7681-93-8 | C33H47NO13 |
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—— | cyclo[OAla-Val-D-OVal-D-Val-OAla-Val-D-OVal-DL-Val-OAla-Val-DL-OVal-D-Val] | 2001-95-8 | C54H90N6O18 |
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—— | (2R,3R)-2,3-dihydroxybutanedioic acid;2-[(4R,5S,6S,7R,9R,11E,15R,16R)-6-[(2S,3R,4R,5S,6R)-5-[(2S,4R,5S,6S)-4,5-dihydroxy-4,6-dimethyloxan-2-yl]oxy-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-16-ethyl-4-hydroxy-15-[[(2R,3R,4R,5R,6R)-5-hydroxy-3,4-dimethoxy-6-methyloxan-2-yl]oxymethyl]-5,9,13-trimethyl-2,10-dioxo-1-oxacyclohexadeca-11,13-dien-7-yl]acetaldehyde | 74610-55-2 | C50H83NO23 |
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