BOC-氨基酸
BOC-氨基酸是一种在合成化学和生物化学研究中常用到的保护基团化氨基酸。这里的“BOC”代表的是Bocyl氯（Benzotriazol-1-yloxy-tris-(dimethylamino)-phosphonium hexafluorophosphate）反应中的“Benzotriazol-1-yl”，而这个名称通常指的是化学中用于酰胺形成的一种保护基。BOC-氨基酸就是在这种保护条件下，与α-氨基形成的衍生物。
在有机化学和药物合成过程中，BOC-氨基酸是一种非常常用的中间体。通过引入BOC保护基团，可以控制或暂时阻止某些敏感的侧链（如α-羟基或α-氨基）参与反应，从而有助于复杂分子的构建和修饰。一旦需要释放这些官能团进行进一步反应时，可以通过酸性条件下的脱保护步骤实现。
例如，在多肽合成中，BOC-氨基酸可以作为起始物料，在固相或液相条件下与其他氨基酸或其它化学实体连接形成肽键。这种操作方法能够有效避免不必要的副反应，并提高产物的纯度和收率。
总之，BOC-氨基酸及其衍生物在现代有机合成、药物化学以及多肽、蛋白质的研究中扮演着极其重要的角色。
| 中文名称 | 英文名称 | CAS号 | 化学式 | 结构式图片 |
|---|---|---|---|---|
| 溴甲基甲基醚 | bromethyl methyl ether | 13057-17-5 | C2H5BrO |
|
| 叔丁氧羰酰基肌氨酸 | N-(tert-butoxycarbonyl)sarcosine | 13734-36-6 | C8H15NO4 |
|
| 叔丁氧羰酰基6-氨基己酸 | 6-(tert-butoxycarbonylamino)hexanoic acid | 6404-29-1 | C11H21NO4 |
|
| 叔丁氧羰基氨氧基乙酸 | (Boc-aminooxy)acetic acid | 42989-85-5 | C7H13NO5 |
|
| 叔丁氧羰基-蛋氨酰-琥珀酰亚胺 | tertbutoxycarbonyl-L-methionine N-hydroxysuccinimide ester | 3845-64-5 | C14H22N2O6S |
|
| 叔丁氧羰基-N-beta-三苯甲基-L-天门冬酰胺 | Boc-Asn(Trt)-OH | 132388-68-2 | C28H30N2O5 |
|
| 叔丁氧羰基-L-2,4-二氨基丁酸 | (2S)-4-amino-2-[(tert-butoxycarbonyl)amino]butanoic acid | 25691-37-6 | C9H18N2O4 |
|
| 叔丁氧羰基-D-蛋氨酸二环己胺盐 | tert.-butoxycarbonyl-D-methionine dicyclohexylamine salt | 61315-59-1 | C10H19NO4S*C12H23N |
|
| 反-4-(BOC氨甲基)环己烷甲酸 | trans-4-[({[(1,1-dimethylethyl)oxy]carbonyl}amino)methyl]cyclohexanecarboxylic acid | 162046-58-4 | C13H23NO4 |
|
| 六氢吡啶-alpha-羧酸 | Pipecolic Acid | 535-75-1 | C6H11NO2 |
|
| 二乙基(Boc-氨基)乙酯 | diethyl tert-butoxycarbonylaminomalonate | 102831-44-7 | C12H21NO6 |
|
| N-叔丁氧羰基二乙胺 | N,N-bis(2-hydroxyethyl)-O-tert-butylcarbamate | 103898-11-9 | C9H19NO4 |
|
| N-叔丁氧羰基-N'-苄氧羰基-L-鸟氨酸 | Boc-Orn(Z)-OH | 2480-93-5 | C18H26N2O6 |
|
| N-叔丁氧羰基-N'-苄氧羰基-D-鸟氨酸 | (R)-5-(((benzyloxy)carbonyl)amino)-2-((tert-butoxycarbonyl)amino)pentanoic acid | 16937-92-1 | C18H26N2O6 |
|
| N-叔丁氧羰基-N'-芴甲氧羰基-L-鸟氨酸 | Boc-Orn(Fmoc)-OH | 150828-96-9 | C25H30N2O6 |
|
| N-叔丁氧羰基-N'-氧蒽基-L-天门冬酰胺 | (S)-2-tert-Butoxycarbonylamino-N-(9H-xanthen-9-yl)-succinamic acid | 65420-40-8 | C22H24N2O6 |
|
| N-叔丁氧羰基-N'-[(烯丙氧基)羰基]-L-鸟氨酸 | Boc-(S)-Orn(Alloc)-OH | 171820-74-9 | C14H24N2O6 |
|
| N-叔丁氧羰基-N'-(2-氯苄氧羰基)-L-鸟氨酸 | N-tert-butoxycarbonyl-N'-(2-chlorobenzyloxycarbonyl)-L-ornithine | 118554-00-0 | C18H25ClN2O6 |
|
| N-叔丁氧羰基-L-蛋氨醇 | (S)-tert-butyl (1-hydroxy-4-(methylthio)butan-2-yl)carbamate | 51372-93-1 | C10H21NO3S |
|
| N-叔丁氧羰基-L-脯氨酰胺 | (S)-tert-butyl 2-carbamoylpyrrolidine-1-carboxylate | 35150-07-3 | C10H18N2O3 |
|
| N-叔丁氧羰基-L-2-氨基-5-苯基戊酸二环己胺盐 | Dicyclohexylamine (S)-2-((tert-butoxycarbonyl)amino)-5-phenylpentanoate | 113756-89-1 | C28H46N2O4 |
|
| N-叔丁氧羰基-D-1,2,3,4-四氢-beta-咔啉-3-甲酸 | Boc-D-1,2,3,4-Tetrahydronorharman-3-carboxylic acid | 123910-26-9 | C17H19N2O4- |
|
| N-叔丁氧羰基-3-(4-联苯基)-D-丙氨酸 | (2R)-3-(biphenyl-4-yl)-2-[(tert-butoxycarbonyl)amino]propanoic acid | 128779-47-5 | C20H23NO4 |
|
| N-叔丁氧羰基-(S)-3-氨基-4-(4-三氟甲基苯基)丁酸 | (3S)-3-({[(1,1-dimethylethyl)oxy]carbonyl}amino)-4-[4-(trifluoromethyl)phenyl]butanoic acid | 270065-80-0 | C16H20F3NO4 |
|
| N-叔丁氧羰基-(S)-3-氨基-4-(3,4-二氟苯基)丁酸 | (S)-3-tert-Butoxycarbonylamino-4-(3,4-difluoro-phenyl)-butyric acid | 270063-54-2 | C15H19F2NO4 |
|
| N-叔丁氧羰基-(S)-3-氨基-4-(2-萘基)丁酸 | Boc-(S)-3-Amino-4-(2-naphthyl)-butyric acid | 219297-11-7 | C19H23NO4 |
|
| N-叔丁氧羰基-(S)-3-氨基-4-(2-溴苯基)丁酸 | Boc-(S)-3-amino-4-(2-bromo-phenyl)-butyric acid | 403661-78-9 | C15H20BrNO4 |
|
| N-叔丁氧羰基-(S)-1,2,3,4-四氢异喹啉-3-羧酸 | (3S)-2-tert-butoxycarbonyl-1,2,3,4-tetrahydroisoquinole-3-carboxylic acid | 78879-20-6 | C15H19NO4 |
|
| N-Boc-N-甲基乙二胺 | (2-aminoethyl)methylcarbamic acid tert-butyl ester | 121492-06-6 | C8H18N2O2 |
|
| N-Boc-L-苯丙氨醛 | Boc-L-phenylalaninal | 72155-45-4 | C14H19NO3 |
|
| N-Boc-L-缬氨酸 | t-Boc-L-valine | 13734-41-3 | C10H19NO4 |
|
| N-Boc-L-哌啶-2-羧酸 | (S)-(-)-1-(tert-butoxycarbonyl)-2-piperidinecarboxylic acid | 26250-84-0 | C11H19NO4 |
|
| N-Boc-DL-缬氨酸 | Boc-Val | 54895-12-4 | C10H19NO4 |
|
| N-Boc-DL-2-氨基丁酸 | 2-((tert-butoxycarbonyl)amino)butanoic acid | 34306-42-8 | C9H17NO4 |
|
| N-Boc-D-色氨醇 | (R)-tert-butyl (1-hydroxy-3-(1H-indol-3-yl)propan-2-yl)carbamate | 158932-00-4 | C16H22N2O3 |
|
| N-Boc-D-哌啶-2-羧酸 | N-BOC-D-pipecolic acid | 28697-17-8 | C11H19NO4 |
|
| N-Boc-4-甲基-4-哌啶甲酸乙酯 | ethyl tert-butyl 4-methylpiperidine-1,4-dicarboxylate | 189442-87-3 | C14H25NO4 |
|
| N-Boc-4-哌啶甲酸乙酯 | 1-tert-butyl 4-ethyl piperidine-1,4-dicarboxylate | 142851-03-4 | C13H23NO4 |
|
| N-Boc-2-哌啶甲酸 | 1-(tert-butoxycarbonyl)piperidine-2-carboxylic acid | 98303-20-9 | C11H19NO4 |
|
| N-Boc-(S)-2-氨基-3-苄氧基-1-丙醇 | tert-butyl (S)-(1-(benzyloxy)-3-hydroxypropan-2-yl)carbamate | 79069-15-1 | C15H23NO4 |
|
| N-Boc-(R)-噻唑-4-羧酸 | N-(tert-butoxycarbonyl)-(R)-thiazolidine-4-carboxylic acid | 51077-16-8 | C9H15NO4S |
|
| N-Boc-(R)-3-甲酸哌啶 | (R)-1-Boc-nipecotic acid | 163438-09-3 | C11H19NO4 |
|
| N-BOC-亚氨基二乙酸 | N-((tert-butyloxy)carbonyl)iminodiacetic acid | 56074-20-5 | C9H15NO6 |
|
| N-BOC-GAMMA-氨基丁酸 | 4-tert-butoxycarbonylaminobutyric acid | 57294-38-9 | C9H17NO4 |
|
| N-BOC-D-氨基丁酸 | Boc-D-Abu | 45121-22-0 | C9H17NO4 |
|
| N-BOC-D-亮氨醇 | tert-butyl [(2R)-1-hydroxy-4-methylpentan-2-yl]carbamate | 106930-51-2 | C11H23NO3 |
|
| N-BOC-4-氨基-4-羧酸哌啶 | 4-amino-1-(tert-butoxycarbonyl)piperidine-4-carboxylic acid | 183673-71-4 | C11H20N2O4 |
|
| N-BOC-4-氧代-3-吡咯烷甲酸乙酯 | 1-tert-butyl 3-ethyl 4-oxopyrrolidine-1,3-dicarboxylate | 146256-98-6 | C12H19NO5 |
|
| N-BOC-4-异丙基-4-哌啶甲酸乙酯 | Ethyl 1-Boc-4-isopropyl-4-piperidinecarboxylate | 1022128-75-1 | C16H29NO4 |
|
| N-BOC-4-乙基-4-哌啶甲酸乙酯 | 1-(tert-butyl) 4-ethyl 4-ethylpiperidine-1,4-dicarboxylate | 188792-70-3 | C15H27NO4 |
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