BOC-氨基酸
BOC-氨基酸是一种在合成化学和生物化学研究中常用到的保护基团化氨基酸。这里的“BOC”代表的是Bocyl氯（Benzotriazol-1-yloxy-tris-(dimethylamino)-phosphonium hexafluorophosphate）反应中的“Benzotriazol-1-yl”，而这个名称通常指的是化学中用于酰胺形成的一种保护基。BOC-氨基酸就是在这种保护条件下，与α-氨基形成的衍生物。
在有机化学和药物合成过程中，BOC-氨基酸是一种非常常用的中间体。通过引入BOC保护基团，可以控制或暂时阻止某些敏感的侧链（如α-羟基或α-氨基）参与反应，从而有助于复杂分子的构建和修饰。一旦需要释放这些官能团进行进一步反应时，可以通过酸性条件下的脱保护步骤实现。
例如，在多肽合成中，BOC-氨基酸可以作为起始物料，在固相或液相条件下与其他氨基酸或其它化学实体连接形成肽键。这种操作方法能够有效避免不必要的副反应，并提高产物的纯度和收率。
总之，BOC-氨基酸及其衍生物在现代有机合成、药物化学以及多肽、蛋白质的研究中扮演着极其重要的角色。
| 中文名称 | 英文名称 | CAS号 | 化学式 | 结构式图片 |
|---|---|---|---|---|
| BOC-(R)-3-氨基-4-(4-溴苯基)-丁酸 | (R)-4-(4-bromophenyl)-3-(tert-butoxycarbonylamino)butanoic acid | 331763-75-8 | C15H20BrNO4 |
|
| BOC-(R)-3-氨基-4-(4-氰基苯基)丁酸 | (3R)-3-(tert-butoxycarbonylamino)-4-(4-cyanophenyl)butanoic acid | 269726-86-5 | C16H20N2O4 |
|
| BOC-(R)-3-氨基-4-(4-三氟甲苯基)丁酸 | (3R)-3-[[(tert-butoxy)carbonyl]amino]-4-[4-(trifluoromethyl)phenyl]butanoic acid | 269726-77-4 | C16H20F3NO4 |
|
| BOC-(R)-3-氨基-4-(3-氯苯基)-丁酸 | (3R)-3-[[(tert-butoxy)carbonyl]amino]-4-(3-chlorophenyl)butanoic acid | 331763-56-5 | C15H20ClNO4 |
|
| BOC-(R)-3-氨基-4-(3-氟苯基)-丁酸 | (3R)-3-[[(tert-butoxy)carbonyl]amino]-4-(3-fluorophenyl)butanoic acid | 331763-66-7 | C15H20FNO4 |
|
| BOC-(R)-3-氨基-4-(3-三氟甲苯基)丁酸 | (R)-3-tert-Butoxycarbonylamino-4-(3-trifluoromethyl-phenyl)-butyric acid | 269726-74-1 | C16H20F3NO4 |
|
| BOC-(R)-3-氨基-4-(3,4-二氯苯基)丁酸 | (3R)-3-(tert-butoxycarbonylamino)-4-(3,4-dichlorophenyl)butanoic acid | 269396-56-7 | C15H19Cl2NO4 |
|
| BOC-(R)-3-氨基-4-(3,4-二氟苯基)丁酸 | (3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(3,4-difluorophenyl)butanoic acid | 269396-59-0 | C15H19F2NO4 |
|
| BOC-(R)-3-氨基-4-(1-萘基)-丁酸 | (R)-N-Boc-3-amino-4-(1-naphthyl)-butanoic acid | 190190-49-9 | C19H23NO4 |
|
| BOC-(R)-3-氨基-4,4-二苯基-丁酸 | Boc-(S)-3-Amino-4,4-diphenyl-butyric acid | 190190-50-2 | C21H25NO4 |
|
| BOC-(R)-3-氨基-3-(3-溴苯基)-丙酸 | (R)-N-Boc-3-Bromo-beta-phenylalanine | 501015-16-3 | C14H18BrNO4 |
|
| BOC-(R)-3-氨基-3-(2-硝基苯基)-丙酸 | (R)-3-((tert-Butoxycarbonyl)amino)-3-(2-nitrophenyl)propanoic acid | 501015-23-2 | C14H18N2O6 |
|
| BOC-(R)-3-氨基-3-(2-甲氧基苯基)-丙酸 | (R)-3-((tert-Butoxycarbonyl)amino)-3-(2-methoxyphenyl)propanoic acid | 500788-85-2 | C15H21NO5 |
|
| BOC-(R)-3-氨基-3-(2-溴苯基)-丙酸 | Boc-(R)-3-Amino-3-(2-bromo-phenyl)-propionic acid | 500789-07-1 | C14H18BrNO4 |
|
| BOC-(R)-3-氨基-3-(2-氯苯基)-丙酸 | (R)-3-((tert-Butoxycarbonyl)amino)-3-(2-chlorophenyl)propanoic acid | 500789-05-9 | C14H18ClNO4 |
|
| BOC-(R)-3-氨基-3-(2-氟苯基)-丙酸 | N-Boc-(R)-3-amino-3-(2-fluorophenyl)propanoic acid | 500789-03-7 | C14H18FNO4 |
|
| BOC-(R)-3-氨基-3-(2,4-二氯苯基)-丙酸 | (R)-3-((tert-Butoxycarbonyl)amino)-3-(2,4-dichlorophenyl)propanoic acid | 500788-90-9 | C14H17Cl2NO4 |
|
| BOC-(R)-3-氨基-3-(2,3-二氯苯基)-丙酸 | (R)-3-((tert-Butoxycarbonyl)amino)-3-(2,3-dichlorophenyl)propanoic acid | 500788-91-0 | C14H17Cl2NO4 |
|
| 4-叔丁氧羰基氨基-4-氨基甲酰基丁酸 | (4S)-4-(N-tert-butoxycarbonylamino)-4-(carbamoyl)butanoic acid | 18800-74-3 | C10H18N2O5 |
|
| 4-N-Boc-氨基-4-羧基四氢硫代吡喃 | 4-((tert-butoxycarbonyl)amino)tetrahydro-2H-thiopyran-4-carboxylic acid | 108329-81-3 | C11H19NO4S |
|
| 3-甲氨基-1-BOC吡咯烷 | tert-butyl (3S)-3-(methylamino)pyrrolidine-1-carboxylate | 147081-59-2 | C10H20N2O2 |
|
| 3-(N-Boc-氨甲基)苯甲酸 | 3-(tert-butoxycarbonylamino-methyl)benzoic acid | 117445-22-4 | C13H17NO4 |
|
| 2-叔丁氧羰基氨基-4-氨基甲酰基丁酸 4-硝基苯酯 | Boc-Gln-ONp | 15387-45-8 | C16H21N3O7 |
|
| 2-[2-(叔丁氧羰基氨基)乙氧基]乙氧基乙酸 | N-(tert-butyloxycarbonyl)-8-amino-3,6-dioxaoctanoic acid | 108466-89-3 | C11H21NO6 |
|
| 2-(N-Cbz)-3-(N-Boc)-2,3-二氨基丙酸 | N-[(benzyloxy)carbonyl]-3-[(tert-butoxycarbonyl)amino]-L-alanine | 16947-84-5 | C16H22N2O6 |
|
| 2-(N-BOC-氨基甲基)-5-氯吡啶 | tert-Butyl ((5-chloropyridin-2-yl)methyl)carbamate | 67938-77-6 | C11H15ClN2O2 |
|
| 1-N-Boc-3-吖丁啶羧酸 | 1-(t-butyloxycarbonyl)-azetidine-3-carboxylic acid | 142253-55-2 | C9H15NO4 |
|
| 1-Boc-吡咯烷-3-甲酸甲酯 | methyl 1-tert-butoxycarbonyl-3-pyrrolidinecarboxylate | 122684-33-7 | C11H19NO4 |
|
| 1-Boc-4-甲基-4-哌啶甲酸 | 1-(tert-butoxycarbonyl)-4-methylpiperidine-4-carboxylic acid | 189321-63-9 | C12H21NO4 |
|
| 1-Boc-4-哌啶甲酸 | N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid | 84358-13-4 | C11H19NO4 |
|
| 1-Boc-4-(Boc-氨基)哌啶-4-甲酸 | 1-(tert-butoxycarbonyl)-4-((tert-butoxycarbonyl)amino)piperidine-4-carboxylic acid | 189321-65-1 | C16H28N2O6 |
|
| 1-Boc-3-甲氨基吡咯烷 | tert-butyl 3-(methylamino)pyrrolidine-1-carboxylate | 454712-26-6 | C10H20N2O2 |
|
| 1-Boc-3-氨甲基哌啶 | tert-butyl 3-(aminomethyl)piperidine-1-carboxylate | 162167-97-7 | C11H22N2O2 |
|
| 1-BOC-哌啶-3-羧酸 | BOC-nipecotic acid | 163438-09-3 | C11H19NO4 |
|
| 1-BOC-吡咯烷-3-甲酸乙酯 | 1-t-butyloxycarbonylpyrrole-3-carboxylic acid ethyl ester | 170844-49-2 | C12H21NO4 |
|
| 1-BOC-4-乙基-4-哌啶甲酸 | 1-(tert-butoxycarbonyl)-4-ethylpiperidine-4-carboxylic acid | 188792-67-8 | C13H23NO4 |
|
| 1-BOC-3-(乙基氨基)氮杂环丁烷 | 3-(ethylamino)azetidine-1-carboxylic acid tert-butyl ester | 454703-23-2 | C10H20N2O2 |
|
| (S)-叔丁氧羰基-4-氟-β-苯丙氨酸 | (3S)-3-(4-fluorophenyl)-3-{[(tert-butoxy)carbonyl]amino}propanoic acid | 479064-88-5 | C14H18FNO4 |
|
| (S)-N-叔丁氧羰基-3-氨基-4-(4-溴苯基)丁酸 | (S)-4-(4-bromophenyl)-3-(tert-butoxycarbonylamino)butanoic acid | 270062-85-6 | C15H20BrNO4 |
|
| (S)-N-叔丁氧羰基-3-氨基-4-(4-氯苯基)丁酸 | (S)-3-((tert-butoxycarbonyl)amino)-4-(4-chlorophenyl)butanoic acid | 270596-42-4 | C15H20ClNO4 |
|
| (S)-N-Boc-吡咯烷-2-甲醛 N-(叔丁氧羰基)-L-脯氨醛 | Boc-L-Pro-H | 69610-41-9 | C10H17NO3 |
|
| (S)-N-Boc-3,3-二甲基吡咯烷-2-甲酸 | 1-(tert-butoxycarbonyl)-3,3-dimethyl-D,L-proline | 174060-98-1 | C12H21NO4 |
|
| (S)-N-BOC-4-氟苯基氨基乙酸 | (S)-2-((tert-butoxycarbonyl)amino)-2-(4-fluorophenyl)acetic acid | 142186-36-5 | C13H16FNO4 |
|
| (S)-N-BOC-2-(5-溴噻吩)苯胺 | (S)-3-(5-Bromothiophen-2-yl)-2-((tert-butoxycarbonyl)amino)propanoic acid | 190319-95-0 | C12H16BrNO4S |
|
| (S)-3-羟基氮杂环庚烷-1-羧酸叔丁酯 | (S)-tert-butyl 3-hydroxyazepane-1-carboxylate | 1493732-95-8 | C11H21NO3 |
|
| (S)-3-(Boc-氨基)-4-苯基丁酸 | (S)-3-tert-butoxycarbonylamino-4-phenylbutanoic acid | 51871-62-6 | C15H21NO4 |
|
| (S)-2,6-二叔丁氧羰基氨基己酸 | Boc-Lys(Boc)-OH | 2483-46-7 | C16H30N2O6 |
|
| (S)-1-N-叔丁氧羰基哌嗪-2-甲酸甲酯 | (S)-1-tert-butyl 2-methyl piperazine-1,2-dicarboxylate | 796096-64-5 | C11H20N2O4 |
|
| (S)-1-Boc-哌嗪-2-羧酸 | (2S)-1-tert-butoxycarbonylpiperazine-2-carboxylic acid | 159532-59-9 | C10H18N2O4 |
|
| (S)-1-Boc-3-氨基哌啶 | tert-butyl (3S)-3-aminopiperidine-1-carboxylate | 625471-18-3 | C10H20N2O2 |
|
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