BOC-氨基酸
BOC-氨基酸是一种在合成化学和生物化学研究中常用到的保护基团化氨基酸。这里的“BOC”代表的是Bocyl氯（Benzotriazol-1-yloxy-tris-(dimethylamino)-phosphonium hexafluorophosphate）反应中的“Benzotriazol-1-yl”，而这个名称通常指的是化学中用于酰胺形成的一种保护基。BOC-氨基酸就是在这种保护条件下，与α-氨基形成的衍生物。
在有机化学和药物合成过程中，BOC-氨基酸是一种非常常用的中间体。通过引入BOC保护基团，可以控制或暂时阻止某些敏感的侧链（如α-羟基或α-氨基）参与反应，从而有助于复杂分子的构建和修饰。一旦需要释放这些官能团进行进一步反应时，可以通过酸性条件下的脱保护步骤实现。
例如，在多肽合成中，BOC-氨基酸可以作为起始物料，在固相或液相条件下与其他氨基酸或其它化学实体连接形成肽键。这种操作方法能够有效避免不必要的副反应，并提高产物的纯度和收率。
总之，BOC-氨基酸及其衍生物在现代有机合成、药物化学以及多肽、蛋白质的研究中扮演着极其重要的角色。
| 中文名称 | 英文名称 | CAS号 | 化学式 | 结构式图片 |
|---|---|---|---|---|
| N-BOC-3-羟基哌啶 | N-tert-butoxycarbonyl-3-piperidinol | 85275-45-2 | C10H19NO3 |
|
| N-BOC-1,6-己二胺盐酸盐 | N-(tert-butoxycarbonyl)-1,6-diaminohexane hydrochloride | 65915-94-8 | C11H24N2O2*ClH |
|
| N-(叔丁氧羰基)-3-溴甲基吖丁啶 | tert-butyl 3-(bromomethyl)azetidine-1-carboxylate | 253176-93-1 | C9H16BrNO2 |
|
| N-(叔丁氧基羰基)-L-缬氨酸N-甲氧基-N-甲基酰胺 | tert-butyl (S)-1-(N-methoxy-N-methylcarbamoyl)-2-methylpropylcarbamate | 87694-52-8 | C12H24N2O4 |
|
| N,N′-二-Boc-硫脲 | N,N'-bis(tert-butoxycarbonyl)thiourea | 145013-05-4 | C11H20N2O4S |
|
| N,N'-双(叔丁氧羰基)-L-胱氨酸 | di-t-butoxycarbonyl-L-cystine | 10389-65-8 | C16H28N2O8S2 |
|
| Boc-d-噻唑烷-4-羧酸 | Boc-Thz-OH | 63091-82-7 | C9H15NO4S |
|
| Boc-S-苄基-L-半光氨酸 | (2R)-3-benzylsulfanyl-2-tert-butoxycarbonylamino-propionic acid | 5068-28-0 | C15H21NO4S |
|
| Boc-L-鸟氨酸 | N2-(tert-butoxycarbonyl)-L-ornithine | 21887-64-9 | C10H20N2O4 |
|
| Boc-L-高烯丙基甘氨酸 | (S)-2-((tert-butoxycarbonyl)amino)hex-5-enoic acid | 208522-13-8 | C11H19NO4 |
|
| Boc-L-异亮氨酸羟基琥珀酰亚胺酯 | N-(tert-butoxy)carbonyl-L-isoleucine N-hydroxysuccinimide ester | 3392-08-3 | C15H24N2O6 |
|
| Boc-L-丙氨醛 | Boc-Ala-H | 79069-50-4 | C8H15NO3 |
|
| Boc-D-2-氨基辛二酸 | (R)-2-((tert-Butoxycarbonyl)amino)octanedioic acid | 75113-71-2 | C13H23NO6 |
|
| Boc-5-氨基戊酸 | 5-(N-tert-butyloxycarbonyl)aminopentanoic acid | 27219-07-4 | C10H19NO4 |
|
| Boc-2-氨甲基苯乙酸 | 2-(2-(((tert-butoxycarbonyl)amino)methyl)phenyl)acetic acid | 40851-66-9 | C14H19NO4 |
|
| Boc-1-氨基环戊烷羧酸 | 1-(tert-butoxycarbonylamino)cyclopentanecarboxylic acid | 35264-09-6 | C11H19NO4 |
|
| Boc-1-氨基环丙基甲酸 | 1-<(tert-butyloxy)carbonylamino>cyclopropane-1-carboxylic acid | 88950-64-5 | C9H15NO4 |
|
| Boc-1-氨基环丁烷羧酸 | 1-[(tert-butoxycarbonyl)amino]cyclobutanecarboxylic acid | 120728-10-1 | C10H17NO4 |
|
| Boc-(r)-3-氨基-4-(2-三氟甲基苯基)丁酸 | (R)-3-tert-Butoxycarbonylamino-4-(2-trifluoromethyl-phenyl)-butyric acid | 269396-77-2 | C16H20F3NO4 |
|
| Boc-(S)-3-氨基-4-(2-三氟甲基苯基)-丁酸 | (S)-3-((tert-butoxycarbonyl)amino)-4-(2-(trifluoromethyl)phenyl)butanoic acid | 270065-74-2 | C16H20F3NO4 |
|
| Boc-(S)-3-氨基-3-(2,3-二氯苯基)-丙酸 | Boc-(S)-3-Amino-3-(2,3-dichloro-phenyl)-propionic acid | 499995-82-3 | C14H17Cl2NO4 |
|
| Boc-(R)-3-氨基-5-己烯酸 | 3-R-t-butoxycarbonylaminohex-5-enoic acid | 269726-94-5 | C11H19NO4 |
|
| Boc-(R)-3-氨基-4-(4-硝基苯基)丁酸 | (R)-3-((tert-Butoxycarbonyl)amino)-4-(4-nitrophenyl)butanoic acid | 219297-12-8 | C15H20N2O6 |
|
| Boc-(R)-3-氨基-4-(4-氯苯基)丁酸 | (R)-3-(tert-butoxycarbonylamino)-4-(4-chlorophenyl)butanoic acid | 218608-96-9 | C15H20ClNO4 |
|
| BOC-PHE-甲氧基甲胺 | Boc-Phe-OH N,O-dimethyl hydroxamate | 87694-53-9 | C16H24N2O4 |
|
| BOC-L-苯胺-4-硝基苯酯 | N-t-butoxycarbonyl-L-phenylalanine 4-nitrophenyl ester | 7535-56-0 | C20H22N2O6 |
|
| BOC-L-环丙基丙氨酸 | dicyclohexylammonium (2S)-2-(tert-butoxycarbonylamino)-3-cyclopropylpropanoate | 89483-07-8 | C11H19NO4*C12H23N |
|
| BOC-L-天门冬氨酸4-叔丁基-1-羟基-琥珀酰亚胺酯 | (S)-4-tert-butyl 1-(2,5-dioxopyrrolidin-1-yl) 2-((tert-butoxycarbonyl)amino)succinate | 50715-50-9 | C17H26N2O8 |
|
| BOC-L-Β-3-氨基-4-(3-氟苯基)-丁酸 | Boc-(S)-3-Amino-4-(3-fluorophenyl)butyric acid | 270596-51-5 | C15H20FNO4 |
|
| BOC-L-2-氨基辛二酸 | N-tert-butoxycarbonyl-L-α-(S)-aminosuberic acid | 66713-87-9 | C13H23NO6 |
|
| BOC-L-2-氨基丁酸 | Boc-Abu | 34306-42-8 | C9H17NO4 |
|
| BOC-L-2-氨基-4-溴戊烯酸 | N-tert-butoxycarbonyl-L-2-amino-4-bromo-4-pentenoic acid | 151215-34-8 | C10H16BrNO4 |
|
| BOC-L-1,2,3,4-四氢-Β-咔啉-3-羧酸 | (3S)-2-tert-butoxycarbonyl-1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid | 66863-43-2 | C17H20N2O4 |
|
| BOC-D-脯氨醛 | N-(BOC)-D-prolinal | 73365-02-3 | C10H17NO3 |
|
| BOC-D-正缬氨酸 | (R)-2-((tert-butoxycarbonyl)amino)pentanoic acid | 57521-85-4 | C10H19NO4 |
|
| BOC-D-2-氨基-4-溴戊烯酸 | Boc-D-2-Amino-4-bromo-4-pentenoic acid | 149930-92-7 | C10H16BrNO4 |
|
| BOC-D-2-四氢异喹啉-乙酸 | ((3R)-2-{[(1,1-dimethylethyl)oxy]carbonyl}-1,2,3,4-tetrahydro-3-isoquinolinyl)ethanoic acid | 332064-64-9 | C16H21NO4 |
|
| BOC-D-1,2,3,4-四氢异喹啉-3-羧酸 | (3R)-2-tert-butoxycarbonyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid | 115962-35-1 | C15H19NO4 |
|
| BOC-8-氨基辛酸 | 8-tert-butoxycarbonylaminooctanoic acid | 30100-16-4 | C13H25NO4 |
|
| BOC-(S)-3-氨基-5-己烯酸 | (S)-3-((tert-butoxycarbonyl)amino)hex-5-enoic acid | 270263-03-1 | C11H19NO4 |
|
| BOC-(S)-3-氨基-4-(4-碘苯基)-丁酸 | (S)-3-((tert-butoxycarbonyl)amino)-4-(4-iodophenyl)butanoic acid | 270065-71-9 | C15H20INO4 |
|
| BOC-(S)-3-氨基-4-(3,4-二氯苯基)-丁酸 | (S)-3-(tert-Butoxycarbonylamino)-4-(3,4-dichloro-phenyl)-butyric acid | 270063-51-9 | C15H19Cl2NO4 |
|
| BOC-(S)-3-氨基-4-(2-氯苯基)-丁酸 | Boc-(S)-3-Amino-4-(2-chlorophenyl)butyric acid | 218608-95-8 | C15H20ClNO4 |
|
| BOC-(S)-3-氨基-4-(2-氟苯基)-丁酸 | (S)-3-tert-Butoxycarbonylamino-4-(2-fluoro-phenyl)-butyric acid | 218608-99-2 | C15H20FNO4 |
|
| BOC-(S)-3-氨基-3-(4-羟基苯基)-丙酸 | (S)-3-Boc-amino-3-(4-hydroxyphenyl)-propanoic acid | 499995-80-1 | C14H19NO5 |
|
| BOC-(S)-3-氨基-3-(3-羟基苯基)-丙酸 | (S)-3-((tert-Butoxycarbonyl)amino)-3-(3-hydroxyphenyl)propanoic acid | 499995-79-8 | C14H19NO5 |
|
| BOC-(S)-3-氨基-3-(3-溴苯基)-丙酸 | (S)-3-(3-bromophenyl)-3-(tert-butoxycarbonylamino)propanoic acid | 500770-76-3 | C14H18BrNO4 |
|
| BOC-(S)-3-氨基-3-(3-氯苯基)-丙酸 | (S)-3-((tert-Butoxycarbonyl)amino)-3-(3-chlorophenyl)propanoic acid | 500770-74-1 | C14H18ClNO4 |
|
| BOC-(S)-3-氨基-3-(3-氟苯基)-丙酸 | (S)-[1-(3-fluoro-phenyl)-3-hydroxy-propyl]-carbamic acid tert-butyl ester | 500770-72-9 | C14H18FNO4 |
|
| BOC-(S)-3-氨基-3-(2-硝基苯基)-丙酸 | (S)-3-((tert-Butoxycarbonyl)amino)-3-(2-nitrophenyl)propanoic acid | 500770-83-2 | C14H18N2O6 |
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