(3R,4S)-3-Methyl-4-((R)-2-methyl-propane-2-sulfinyl)-4-(3,4,5-trimethoxy-phenyl)-butyric acid | 141069-51-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 苯丙酸
• 英文名称: (3R,4S)-3-Methyl-4-((R)-2-methyl-propane-2-sulfinyl)-4-(3,4,5-trimethoxy-phenyl)-butyric acid
• CAS: 141069-51-4
• 化学式: C₁₈H₂₈O₆S
• 分子量: 372.483
• InChiKey: GMTJSYYCXKDYIT-KVKIJLJGSA-N

反应信息

• 作为反应物：
  描述：

  (3R,4S)-3-Methyl-4-((R)-2-methyl-propane-2-sulfinyl)-4-(3,4,5-trimethoxy-phenyl)-butyric acid 在 lithium aluminium tetrahydride 作用下， 以93%的产率得到(3S,4R)-3-Methyl-4-((S)-2-methyl-propane-2-sulfinyl)-4-(3,4,5-trimethoxy-phenyl)-butan-1-ol
  参考文献：
  名称：

  A novel stereoselective route to γ-butyrolactones

  摘要：

  Treatment of the products obtained from conjugate additions of sulfoxides to alpha,beta-unsaturated carbonyl compounds with soft electrophiles resulted in intramolecular displacement of the sulfinyl group by the carbonyl to give gamma-butyrolactones. This novel cyclisation works best for benzylic sulfoxides and provides a concise route to trans-beta,gamma-disubstituted lactones with high stereoselectivity.

  DOI：

  10.1016/s0040-4039(00)91589-2