diethyl (R)-[2-hydroxy-2-(1-naphthyl)ethyl]phosphonate | 1239972-55-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: diethyl (R)-[2-hydroxy-2-(1-naphthyl)ethyl]phosphonate
• CAS: 1239972-55-4
• 化学式: C₁₆H₂₁O₄P
• 分子量: 308.314
• InChiKey: SZUDFTNCEJPKMG-INIZCTEOSA-N

反应信息

• 作为产物：
  描述：

  邻氟苯甲酰氯 、 diethyl [2-hydroxy-2-(1-naphthyl)ethyl]phosphonate 在 copper(II) bis(trifluoromethanesulfonate) 、 potassium carbonate 、 (R,R)-2,2'-异亚丙基双(4-苯基-2-恶唑啉) 作用下， 以 二氯甲烷 为溶剂， 生成 diethyl (R)-[2-hydroxy-2-(1-naphthyl)ethyl]phosphonate 、 diethyl (S)-[2-hydroxy-2-(1-naphthyl)ethyl]phosphonate 、 diethyl (S)-[2-(2-fluorobenzoyloxy)-2-(1-naphthyl)ethyl]phosphonate 、 diethyl (R)-[2-(2-fluorobenzoyloxy)-2-(1-naphthyl)ethyl]phosphonate
  参考文献：
  名称：

  Nonenzymatic kinetic resolution of racemic β-hydroxyalkanephosphonates with a chiral copper catalyst

  摘要：

  Kinetic resolution of beta-hydroxyalkanephosphonates was efficiently performed by 2-fluorobenzoylation in the presence of copper(II) triflate and (R,R)-Ph-BOX as a catalyst with good s value of up to 21 (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2010.04.059