| 1345332-68-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• CAS: 1345332-68-4
• 化学式: C₃₆H₄₀N₂O₆S₂
• 分子量: 660.855
• InChiKey: CQNIZPLPXFCNKQ-KYJUHHDHSA-N

反应信息

• 作为反应物：
  描述：

  在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 以100%的产率得到
  参考文献：
  名称：

  Chelate oxorhenium to assemble new integrin antagonists

  摘要：

  Assembly of independent chemical modules through oxorhenium coordination by a NS2 + S chelation motif was applied to the synthesis of RGD (Arg-Gly-Asp) analogs. Modules were assembled through oxorhenium chelation to give a series of 18 metal complexes in good yields and satisfactory purities. Screening of these oxorhenium coordinates as antagonists of integrins alpha V beta 3, alpha IIb beta 3 and alpha V beta 5 led to the identification of 3 bioactive compounds that exhibit submicromolar affinities for the 3 integrins. Preliminary studies showed that the corresponding oxotechnetium complexes are stable in mice plasma and therefore could be proposed for the molecular imaging of pathologies that overexpress integrins alpha V beta 3 and alpha V beta 5. (C) 2011 Elsevier Inc. All rights reserved.

  DOI：

  10.1016/j.jinorgbio.2011.03.008