| 1522093-27-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• CAS: 1522093-27-1
• 化学式: C₁₇H₁₂ClNO₃
• 分子量: 313.74
• InChiKey: FIEUJIAVBDXZSZ-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  在 copper(l) iodide 、 碘 、 potassium carbonate 、 sodium iodide 作用下， 以 乙腈 为溶剂， 反应 15.0h， 生成 1-(4-Chlorophenyl)-8-methyl-1,2-dihydrochromeno[2,3-b]azepine-3,6-dione
  参考文献：
  名称：

  Iodine/CuI-mediated alkyne–carbonyl metathesis reaction: synthesis of 1-aryl-1,2-dihydrochromeno[2,3-b]azepine-3,6-dione

  摘要：

  Iodine/cuprous iodide-mediated intramolecular alkyne carbonyl metathesis reaction has been developed using 2,-(N-aryl-N-propargyl)aminochromone-3-carbaldehyde as the substrate. It led to the synthesis of hitherto unreported chromeno[2,3-b]azepine-3,6-dione. The special features of this methodology are mild reaction conditions, 100% atom economy and use of inexpensive reagents. This is the first example of I-2/Cul-mediated alkyne carbonyl metathesis reaction. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2013.11.062