(R)-tert-butyl 4-((R)-2-hydroxy-1-phenylethyl)-3-p-tolypiperazine-1-carboxylate | 1399859-45-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: (R)-tert-butyl 4-((R)-2-hydroxy-1-phenylethyl)-3-p-tolypiperazine-1-carboxylate
• CAS: 1399859-45-0
• 化学式: C₂₄H₃₂N₂O₃
• 分子量: 396.53
• InChiKey: BGNLJCUYNGIAHV-VXKWHMMOSA-N

反应信息

• 作为反应物：
  描述：

  (R)-tert-butyl 4-((R)-2-hydroxy-1-phenylethyl)-3-p-tolypiperazine-1-carboxylate 在 20% Pd(OH)2/C 、 氢气 作用下， 以 乙醇 为溶剂， 反应 18.0h， 以90%的产率得到(R)-tert-butyl 3-p-tolypiperazine-1-carboxylate
  参考文献：
  名称：

  Stereoselective synthesis of enantiopure N-protected-3-arylpiperazines from keto-esters

  摘要：

  An efficient method for a stereoselective synthesis of optically pure N-Boc-3-arylpiperazines has been developed. After optimization of the protecting group strategy and experimental conditions, compounds were obtained via a highly stereoselective synthesis in up to 45% overall yield. This is a practical route to optically pure piperazines for medicinal chemistry. (c) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.07.031
• 作为产物：
  描述：

  二碳酸二叔丁酯 、 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 18.0h， 以114 mg的产率得到(R)-tert-butyl 4-((R)-2-hydroxy-1-phenylethyl)-3-p-tolypiperazine-1-carboxylate
  参考文献：
  名称：

  Stereoselective synthesis of enantiopure N-protected-3-arylpiperazines from keto-esters

  摘要：

  An efficient method for a stereoselective synthesis of optically pure N-Boc-3-arylpiperazines has been developed. After optimization of the protecting group strategy and experimental conditions, compounds were obtained via a highly stereoselective synthesis in up to 45% overall yield. This is a practical route to optically pure piperazines for medicinal chemistry. (c) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.07.031