5-(1,3,4,9a-Tetrahydro-1-oxo-4a(2H)-dibenzothienyl)-2-pentenoic acid, ethyl ester | 130520-38-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 硫铬烷
• 英文名称: 5-(1,3,4,9a-Tetrahydro-1-oxo-4a(2H)-dibenzothienyl)-2-pentenoic acid, ethyl ester
• CAS: 130520-38-6
• 化学式: C₁₉H₂₂O₃S
• 分子量: 330.448
• InChiKey: BWFXYQSCVRQCGV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.05
• 重原子数：
  23.0
• 可旋转键数：
  5.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  43.37
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  5-(1,3,4,9a-Tetrahydro-1-oxo-4a(2H)-dibenzothienyl)-2-pentenoic acid, ethyl ester 在 sodium carbonate 作用下， 以 甲醇 、 苯 为溶剂， 生成 1,2,3,4-Tetrahydro-4-oxo-4a,9b-propanodibenzothiophene-12-acetic acid, ethyl ester
  参考文献：
  名称：

  Tandem photocyclization-intramolecular addition reactions of aryl vinyl sulfides. Observation of a novel [2 + 2] cycloaddition-allylic sulfide rearrangement

  摘要：

  Photocyclization of aryl vinyl sulfides reportedly proceeds via thiocarbonyl ylide intermediates. The photochemical behavior of several aryl vinyl sulfides, which incorporate a pendant alkene side chain, was explored. In general, naphthyl and phenyl vinyl thioethers provided products which are consistent with photocyclization to a thiocarbonyl ylide intermediate followed by either intramolecular hydrogen shift or subsequent intramolecular ylide-alkene addition. Product distribution is influenced by solvent and temperature effects. Novel secondary photoprocesses were also observed during some reactions. Thus, irradiation of naphthyl vinyl sulfide 20 gave dihydrothiophene 22 which underwent subsequent intramolecular [2 + 2] cycloaddition to provide 24. Upon prolonged irradiation 24 undergoes a novel allylic sulfide rearrangement to provide 25.

  DOI：

  10.1021/jo00030a022
• 作为产物：
  描述：

  2-(Phenylthio)-3-oxo-1-cyclohexene-1-propanal 在 sodium hydride 、 二甲基亚砜 作用下， 以 甲苯 为溶剂， 反应 4.08h， 生成 5-(1,3,4,9a-Tetrahydro-1-oxo-4a(2H)-dibenzothienyl)-2-pentenoic acid, ethyl ester
  参考文献：
  名称：

  Tandem photocyclization-intramolecular addition reactions of aryl vinyl sulfides. Observation of a novel [2 + 2] cycloaddition-allylic sulfide rearrangement

  摘要：

  Photocyclization of aryl vinyl sulfides reportedly proceeds via thiocarbonyl ylide intermediates. The photochemical behavior of several aryl vinyl sulfides, which incorporate a pendant alkene side chain, was explored. In general, naphthyl and phenyl vinyl thioethers provided products which are consistent with photocyclization to a thiocarbonyl ylide intermediate followed by either intramolecular hydrogen shift or subsequent intramolecular ylide-alkene addition. Product distribution is influenced by solvent and temperature effects. Novel secondary photoprocesses were also observed during some reactions. Thus, irradiation of naphthyl vinyl sulfide 20 gave dihydrothiophene 22 which underwent subsequent intramolecular [2 + 2] cycloaddition to provide 24. Upon prolonged irradiation 24 undergoes a novel allylic sulfide rearrangement to provide 25.

  DOI：

  10.1021/jo00030a022