硫代苯并二氢吡喃-3-胺 | 124499-23-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 硫铬烷
• 中文名称: 硫代苯并二氢吡喃-3-胺
• 中文别名: 硫代色满-3-胺
• 英文名称: 3,4-dihydro-2H[1]-benzothiopyran-3-amine
• 英文别名: Thiochroman-3-ylamine；3,4-dihydro-2H-thiochromen-3-amine
• CAS: 124499-23-6
• 化学式: C₉H₁₁NS
• mdl: MFCD04114514
• 分子量: 165.259
• InChiKey: HMJPRXLPAGOYFX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.333
• 拓扑面积：
  51.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  6-氯嘌呤核苷 、 硫代苯并二氢吡喃-3-胺 在 三乙胺 作用下， 以 乙醇 为溶剂， 生成 (2R,3R,4S,5R)-2-[6-(3,4-dihydro-2H-thiochromen-3-ylamino)purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
  参考文献：
  名称：

  N6-Substituted adenosine receptor agonists: potential antihypertensive agents

  摘要：

  Adenosine is known to exert a wide range of pharmacological effects including hypotension. This effect of adenosine suggested that modified analogues of adenosine might provide useful antihypertensive agents. Thus, we prepared a series of novel N6-benzocycloalkyladenosines and studied their receptor binding and antihypertensive activity. The structure-activity relationship study shows that the adenosine analogues having the hydrophobic phenyl moiety one carbon away from the C6-nitrogen have modest affinity and selectivity for the A1 receptor, whereas those with the phenyl moiety two carbons away from the C6-nitrogen have excellent affinity and selectivity for the A1 receptor. Many of these analogues showed excellent antihypertensive activity with a wide range of effects on heart rate. There is no direct correlation between the receptor binding affinities and antihypertensive activity; however, it is more closely associated with A1 than A2 affinity. The bradycardic effect of these agonists seems to be due to the A1 affinity. From this set, compound 3 was further evaluated in secondary antihypertensive screens. It lowered the blood pressure dose dependently with effects lasting for over 20 h following administration of a 30 mg/kg dose. Compound 3 was also effective in lowering blood pressure in a renal hypertensive rat model. Thus, appropriately modified N6-substituted adenosines represent a novel class of antihypertensive agents.

  DOI：

  10.1021/jm00107a025

文献信息

• [EN] PROCESS FOR PREPARING BICYCLIC AMINE DERIVATIVES<br/>[FR] PROCÉDÉ DE PRÉPARATION DE DÉRIVÉS D'AMINE BICYCLIQUE
  申请人：ABBVIE INC

  公开号：WO2014008350A1

  公开（公告）日：2014-01-09

  The present invention provides a process for preparing a bicyclic amine derivative of the for-mula (Ia) or (Ib), (Formulae (Ia) (Ib)) comprising the rhodium-catalyzed asymmetric hydrogenation of an enamine of the formula (II), (Formula (II)) in the presence of a chiral ligand, wherein the chiral ligand is a chiral phosphine ligand.

  本发明提供了一种制备式(Ia)或(Ib)的双环胺衍生物的过程，其中(Ia)(Ib)式包括在手性配体存在下对式(II)的恩醛进行铑催化的不对称氢化，其中手性配体是手性膦配体。
• PROCESS FOR PREPARING BICYCLIC AMINE DERIVATIVES
  申请人：AbbVie Inc.

  公开号：US20140012015A1

  公开（公告）日：2014-01-09

  The present invention provides a process for preparing a bicyclic amine derivative of the formula (Ia) or (Ib), comprising the rhodium-catalyzed asymmetric hydrogenation of an enamine of the formula (II), in the presence of a chiral ligand, wherein the chiral ligand is a chiral phosphine ligand.

  本发明提供了一种制备式(Ia)或(Ib)的双环胺衍生物的过程，包括在手性配体的存在下，通过催化作用的氢化反应将式(II)的恩酰胺还原为所需产物，其中手性配体是手性膦配体。
• Certain 2-substituted adenosine derivatives
  申请人：CIBA-GEIGY AG

  公开号：EP0323807A2

  公开（公告）日：1989-07-12

  Disclosed are 2-substituted adenosine derivatives of the formula wherein R represents a substituted amino grouping as defined in the specification, which are therapeutically effective adenosine-2 (A-2) agonists. They are prepared by methods known per se.

  公开了式中的 2-取代腺苷衍生物 其中 R 代表说明书中定义的取代氨基，是治疗有效的腺苷-2（A-2）激动剂。它们是通过本身已知的方法制备的。
• Nouveaux dérivés du 3-aminochromane, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent
  申请人：ADIR ET COMPAGNIE

  公开号：EP0452204A1

  公开（公告）日：1991-10-16

  L'invention concerne les dérivés de formule générale (I) : dans laquelle : - Z représente un atome d'oxygène ou un atome de soufre, - R1 représente un atome d'hydrogène, ou un groupement alkyle, - R2 représente un atome d'hydrogène ou un groupement alkyle, - 1≦n≦6, - R3 représente un groupement nitrile, un groupement amino éventuellement substitué ou l'un quelconque des groupements décrits dans la description. Médicaments.

  本发明涉及通式(I)的衍生物： 其中 - Z 代表氧原子或硫原子、 - R1 代表氢原子或烷基 - R2 代表氢原子或烷基、 - 1≦n≦6, - R3 代表腈基、任选取代的氨基或描述中所述的任何基团。 药物。
• TRIVEDI, BHARAT K.
  作者：TRIVEDI, BHARAT K.

  DOI：——

  日期：——