6-Methoxy-3,3-dimethyl-1,2,3,4-tetrahydro-isochinolin | 100368-97-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四氢异喹啉
• 英文名称: 6-Methoxy-3,3-dimethyl-1,2,3,4-tetrahydro-isochinolin
• 英文别名: 6-Methoxy-3,3-dimethyl-1,2,3,4-tetrahydroisoquinoline；6-methoxy-3,3-dimethyl-2,4-dihydro-1H-isoquinoline
• CAS: 100368-97-6
• 化学式: C₁₂H₁₇NO
• 分子量: 191.273
• InChiKey: STRYGVAUUKVJRU-UHFFFAOYSA-N

物化性质

• 沸点：
  291.8±40.0 °C(Predicted)
• 密度：
  0.982±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  21.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  6-Methoxy-3,3-dimethyl-1,2,3,4-tetrahydro-isochinolin 在 sodium tungstate 、 双氧水 作用下， 以 乙醇 为溶剂， 生成 3,3-dimethyl-6-methoxy-3,4-dihydroisoquinoline-N-oxide
  参考文献：
  名称：

  Synthesis and radical scavenging activity of 3,3-dialkyl-3,4-dihydro-isoquinoline 2-oxides

  摘要：

  The syntheses and antioxidant activities of several cyclic nitrones related to phenyl t-butyl nitrone (PBN) are described. These nitrones may act as radical scavengers and have potential uses in the treatment of stroke and septic shock. (C) 1996 Elsevier Science Ltd

  DOI：

  10.1016/0960-894x(96)00181-3
• 作为产物：
  描述：

  在 sodium tetrahydroborate 、 硫酸 作用下， 以 甲醇 为溶剂， 生成 6-Methoxy-3,3-dimethyl-1,2,3,4-tetrahydro-isochinolin
  参考文献：
  名称：

  Synthesis and radical scavenging activity of 3,3-dialkyl-3,4-dihydro-isoquinoline 2-oxides

  摘要：

  The syntheses and antioxidant activities of several cyclic nitrones related to phenyl t-butyl nitrone (PBN) are described. These nitrones may act as radical scavengers and have potential uses in the treatment of stroke and septic shock. (C) 1996 Elsevier Science Ltd

  DOI：

  10.1016/0960-894x(96)00181-3

文献信息

• [EN] PYRIMIDINE COMPOUNDS FOR USE AS MAP4K1 INHIBITORS<br/>[FR] COMPOSÉS DE PYRIMIDINE DESTINÉS À ÊTRE UTILISÉS EN TANT QU'INHIBITEURS DE MAP4K1
  申请人：[en]GLENMARK SPECIALTY S.A.

  公开号：WO2023281417A1

  公开（公告）日：2023-01-12

  The present disclosure is directed to compounds of formula (I) and pharmaceutically acceptable salts thereof, which are useful as MAP4K1 inhibitors, processes for their preparation, pharmaceutical compositions comprising the compounds, and the use of the compounds or the compositions in the treatment or prevention of various diseases, conditions and/or disorders mediated by MAP4K1. (I)