lucidimine C

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: lucidimine C
• 英文别名: Lucidimine C；9-methoxy-8-oxa-17-azatetracyclo[8.7.0.02,7.011,15]heptadeca-1(17),2(7),3,5,10,15-hexaen-4-ol
• 化学式: C₁₆H₁₅NO₃
• 分子量: 269.3
• InChiKey: AYNKXQSWVXZEJE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  20
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  51.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  lucidimine C 在 Daicel Chiralpak IC 作用下， 以1.04 mg的产率得到(9R)-9-methoxy-8-oxa-17-azatetracyclo[8.7.0.02,7.011,15]heptadeca-1(17),2(7),3,5,10,15-hexaen-4-ol
  参考文献：
  名称：

  Racemic alkaloids from the fungus Ganoderma cochlear

  摘要：

  Seven pairs of new alkaloid enantiomers, ganocochlearines C-I (1, 3-8), and three pairs of known alkaloids were isolated from the fruiting bodies of Ganoderma cochlear. The chemical structures of new compounds were elucidated on the basis of 1D and 2D NMR data. The absolute configurations of compounds 1,3-10 were assigned by ECD calculations. Biological activities of these isolates against renal fibrosis were accessed in rat normal or diseased renal interstitial fibroblast cells. Importantly, the plausible biosynthetic pathway for this class of alkaloids was originally proposed. (C) 2016 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.fitote.2016.11.011