spiro[(1,2,3,4,10,11-hexahydrobenzo[c]pyrano[3,2-g]chromen-5-thione)-9,1'-cyclohexane] | 919748-91-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: spiro[(1,2,3,4,10,11-hexahydrobenzo[c]pyrano[3,2-g]chromen-5-thione)-9,1'-cyclohexane]
• 英文别名: 1,2,3,4,10,11-hexahydro-5H-spiro[benzo[c]pyrano[3,2-g]chromene-9,1'-cyclohexane]-5-thione；spiro[1,2,3,4,10,11-hexahydroisochromeno[4,3-g]chromene-9,1'-cyclohexane]-5-thione
• CAS: 919748-91-7
• 化学式: C₂₁H₂₄O₂S
• 分子量: 340.486
• InChiKey: SRCZDDLLKBJZNP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  24
• 可旋转键数：
  0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  50.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  spiro[(1,2,3,4,10,11-hexahydrobenzo[c]pyrano[3,2-g]chromen-5-thione)-9,1'-cyclohexane] 在 吡啶 、 盐酸羟胺 作用下， 反应 6.0h， 以94%的产率得到spiro[(1,2,3,4,10,11-hexahydrobenzo[c]pyrano[3,2-g]chromen-5-one)-9,1'-cyclohexane] oxime
  参考文献：
  名称：

  Synthesis of amino acid derivatives of hydrazones and oximes of spirodihydropyranochromen-2-ones

  摘要：

  Sulfur-and nitrogen-containing derivatives of spirodihydropyranochromen-2-ones at the exocyclic oxygen atom have been synthesized. Modification of the oximes and hydrazones of the spiro-substituted pyranocoumarins with N-substituted amino acids were carried out using activated ester and symmetrical anhydride methods.

  DOI：

  10.1007/s10593-008-0033-5
• 作为产物：
  描述：

  spiro[(1,2,3,4,10,11-hexahydrobenzo[c]pyrano[3,2-g]chromen-5-one)-9,1'-cyclohexane] 在 劳森试剂 作用下， 以 甲苯 为溶剂， 反应 4.0h， 以95%的产率得到spiro[(1,2,3,4,10,11-hexahydrobenzo[c]pyrano[3,2-g]chromen-5-thione)-9,1'-cyclohexane]
  参考文献：
  名称：

  Synthesis of amino acid derivatives of hydrazones and oximes of spirodihydropyranochromen-2-ones

  摘要：

  Sulfur-and nitrogen-containing derivatives of spirodihydropyranochromen-2-ones at the exocyclic oxygen atom have been synthesized. Modification of the oximes and hydrazones of the spiro-substituted pyranocoumarins with N-substituted amino acids were carried out using activated ester and symmetrical anhydride methods.

  DOI：

  10.1007/s10593-008-0033-5

文献信息

• Synthesis of amino acid derivatives of hydrazones and oximes of spirodihydropyranochromen-2-ones
  作者：M. V. Veselovska、M. M. Garazd、O. S. Ogorodniychuk、Ya. L. Garazd、V. P. Khilya

  DOI：10.1007/s10593-008-0033-5

  日期：2008.2

  Sulfur-and nitrogen-containing derivatives of spirodihydropyranochromen-2-ones at the exocyclic oxygen atom have been synthesized. Modification of the oximes and hydrazones of the spiro-substituted pyranocoumarins with N-substituted amino acids were carried out using activated ester and symmetrical anhydride methods.