1-Methyl-7-acetylnaphthalin | 67757-62-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1-Methyl-7-acetylnaphthalin
• 英文别名: 7-acetyl-1-methylnaphthalene；1-(8-Methylnaphthalen-2-yl)ethanone
• CAS: 67757-62-4
• 化学式: C₁₃H₁₂O
• 分子量: 184.238
• InChiKey: XKANDOMUHSYEJH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  甲基碘化镁 、 alkaline earth salt of/the/ methylsulfuric acid 在 乙醚 、 甲苯 作用下， 生成 1-Methyl-7-acetylnaphthalin
  参考文献：
  名称：

  428.烷基菲的合成。第八部分。尝试合成4：5-二甲基菲

  摘要：

  DOI：

  10.1039/jr9340001950

文献信息

• NITROGENOUS-RING ACYLGUANIDINE DERIVATIVE
  申请人：Kinoyama Isao

  公开号：US20120142727A1

  公开（公告）日：2012-06-07

  [Object] An excellent agent for preventing or treating dementia, schizophrenia, and the like, based on serotonin 5-HT 5A receptor modulating action, is provided. [Means for Solution] It was confirmed that acylguanidine derivatives (the following formula I; any one of Z 1 , Z 2 , Z 3 , Z 4 and Z 5 is nitrogen atom, and the others are carbon atoms) which have the characteristic structure in which the guanidine is bonded to one ring of the quinoline or isoquinoline via a carbonyl group, and a cyclic group is bonded to the other ring, exhibit potent 5-HT 5A receptor modulating actions and excellent pharmacological actions based on the 5-HT 5A receptor modulating action, and thus can be excellent agents for preventing or treating dementia, schizophrenia, bipolar disorder, or attention deficit hyperactivity disorder. Thus, the present invention has been completed.

  提供一个基于调节5-HT5A受体的作用，用于预防或治疗痴呆、精神分裂症等的优秀药剂。[解决方案]确认了酰脒衍生物（以下公式I；Z1、Z2、Z3、Z4和Z5中的任何一个为氮原子，其余为碳原子）具有特征性结构，其中脒基通过羰基与喹啉或异喹啉的一个环连接，并且另一个环连接有环状基团，展现出强大的5-HT5A受体调节作用和基于5-HT5A受体调节作用的优秀药理作用，因此可作为预防或治疗痴呆、精神分裂症、双相情感障碍或注意力缺陷多动障碍的优秀药剂。因此，完成了本发明。
• SUBSTITUTED ACYLGUANIDINE DERIVATIVES (AS AMENDED)
  申请人：Kinoyama Isao

  公开号：US20120041036A1

  公开（公告）日：2012-02-16

  An object of the present invention is to provide an excellent agent for treating or preventing dementia, schizophrenia based on serotonin 5-HT 5A receptor modulating action. It was discovered that acylguanidine derivatives, in which the guanidine is bonded to one ring of a naphthalene via a carbonyl group and a cyclic group is bonded to the other ring thereof, exhibit potent the 5-HT 5A receptor modulating action and excellent pharmacological actions based on the action. The present invention is useful as an excellent agent for treating or preventing dementia, schizophrenia, bipolar disorder or attention deficit hyperactivity disorder.

  本发明的目的是提供一种基于血清素5-HT5A受体调节作用的用于治疗或预防痴呆症、精神分裂症的优良药剂。发现酰基胍衍生物，其中胍基通过一个羰基与萘的一个环相结合，另一个环上结合有一个环状基团，表现出强效的5-HT5A受体调节作用和基于该作用的优良药理作用。本发明可用作治疗或预防痴呆症、精神分裂症、躁郁症或注意力缺陷多动障碍的优良药剂。
• ACYLGUANIDINE DERIVATIVES
  申请人：Kinoyama Isao

  公开号：US20110306621A1

  公开（公告）日：2011-12-15

  An object of the present invention is to provide an excellent agent for treating or preventing dementia, schizophrenia based on a serotonin 5-HT 5A receptor modulating action. It was confirmed that acylguanidine derivatives, which has the characteristic structure in which the guanidine is bonded to one ring of a naphthalene via a carbonyl group and a cyclic group is bonded to the other ring thereof, exhibit potent 5-HT 5A receptor modulating action and excellent pharmacological action based on the action. The present invention is useful as an excellent agent for treating or preventing dementia, schizophrenia, bipolar disorder or attention deficit hyperactivity disorder.

  本发明的目的是提供一种基于5-羟色胺5-HT5A受体调节作用的治疗或预防痴呆症、精神分裂症的优良药剂。经确认，酰基胍衍生物具有特征结构，其中胍基通过羰基和环状基团与萘的一个环结合，另一个环上结合环状基团，表现出强效的5-HT5A受体调节作用和优良的药理作用。本发明可用作治疗或预防痴呆症、精神分裂症、双相障碍或注意力缺陷多动障碍的优良药剂。
• Process for producing acyloxynaphthoic acids
  申请人：MITSUBISHI GAS CHEMICAL COMPANY, INC.

  公开号：EP0170273A2

  公开（公告）日：1986-02-05

  A process for producing an acyloxynaphthoic acid represented by the general formula wherein R, represents a hydrogen atom or an alkyl group, which comprises (a) oxidising an acylalkylnaphthalene represented by the general formula wherein R, is as defined, and R2 represents a lower alkyl group, with a peroxide, and (b) oxidising the resulting acyloxyalkylnapththalene represented by the general formula wherein R, and R2 are as defined above, with molecular oxygen in an organic solvent in the presence of a catalyst comprising a bromine compound and a cobalt compound.

  一种生产由通式表示的酰氧基萘酸的工艺 其中 R 代表氢原子或烷基、 该工艺包括 (a) 氧化通式所代表的酰基烷基萘 其中 R 如所定义，R2 代表低级烷基、 与过氧化物氧化，以及 (b) 将所得的由通式表示的酰氧基烷基萘氧化 其中 R 和 R2 如上所定义，在由溴化合物和钴化合物组成的催化剂存在下，在有机溶剂中用分子氧氧化。
• US4801737A
  申请人：——

  公开号：US4801737A

  公开（公告）日：1989-01-31