3-(Chlorocarbonyl)-4-oxo-4H-1-benzopyran-6,7-diyl diacetate | 76903-11-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 3-(Chlorocarbonyl)-4-oxo-4H-1-benzopyran-6,7-diyl diacetate
• 英文别名: (7-acetyloxy-3-carbonochloridoyl-4-oxochromen-6-yl) acetate
• CAS: 76903-11-2
• 化学式: C₁₄H₉ClO₇
• 分子量: 324.67
• InChiKey: VFPXTDDWBWZLHC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  96
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  左旋苯甘氨酸 、 3-(Chlorocarbonyl)-4-oxo-4H-1-benzopyran-6,7-diyl diacetate 生成 (2R)-2-[(6,7-diacetyloxy-4-oxochromene-3-carbonyl)amino]-2-phenylacetic acid
  参考文献：
  名称：

  HOMOTO, SEHJITIRO;IKITA, XIRONORI;MATIDA, JOSIMASA;NEHGI, SIGEHXIKO;SUGIY+

  摘要：

  DOI：
• 作为产物：
  描述：

  6,7-diacetoxy-4-oxo-4H-1-benzopyran-3-carboxylic acid 生成 3-(Chlorocarbonyl)-4-oxo-4H-1-benzopyran-6,7-diyl diacetate
  参考文献：
  名称：

  MACHIDA, YOSHIMASA;SAITO, ISAO;NOMOTO, SEIICHIRO;NEGI, SHIGETO;IKUTA, HIR+

  摘要：

  DOI：

文献信息

• 7.alpha.-Methoxycephalosporin derivatives, and antibacterial drugs
  申请人：Eisai Co., Ltd.

  公开号：US04415567A1

  公开（公告）日：1983-11-15

  Novel 7.alpha.-methoxycephalosporin derivatives, their pharmaceutically acceptable salts, process for the preparation thereof, and antibacterial drugs involving the derivative or salt. The derivatives or salts are effective against the Gram-positive bacteria and the Gram-negative bacteria.

  小说7.alpha.-甲氧基头孢菌素衍生物，其药用盐，其制备方法，以及涉及该衍生物或盐的抗菌药物。这些衍生物或盐对革兰氏阳性菌和革兰氏阴性菌有效。
• Cephalosporin derivatives, and antibacterial drugs comprising said
  申请人：Eisai Co., Ltd.

  公开号：US04285940A1

  公开（公告）日：1981-08-25

  New cephalosporin derivatives having the general formula: ##STR1## wherein R.sub.1 and R.sub.2 each represents hydroxy or acyloxy and their salts, and processes for the production thereof. The cephalosporin derivatives of the present invention are useful as antibacterial drugs.

  新的头孢菌素衍生物具有一般式：##STR1## 其中R.sub.1和R.sub.2分别表示羟基或乙酰氧基及其盐，并且制备它们的工艺。本发明的头孢菌素衍生物可用作抗菌药物。
• Cephalosporin derivatives, and antibacterial drugs containing the
  申请人：Eisai Co., Ltd.

  公开号：US04285939A1

  公开（公告）日：1981-08-25

  New cephalosporin derivatives represented by the general formula: ##STR1## wherein R.sub.1, R.sub.2, and R.sub.3 each represents hydroxy, acyloxy, and hydrogen provided that two or three of R.sub.1, R.sub.2, and R.sub.3 are not hydrogen at the same time, and their salts, and processes for the preparation thereof. The cephalosporin derivatives of the present invention are useful as antibacterial drugs.

  新的头孢菌素衍生物，其通式为：##STR1## 其中R.sub.1，R.sub.2和R.sub.3分别表示羟基，酰氧基和氢，前提是R.sub.1，R.sub.2和R.sub.3中的两个或三个不同时为氢，以及它们的盐，以及制备它们的过程。本发明的头孢菌素衍生物可用作抗菌药物。
• Cephalosporin compounds and antibacterial drugs containing the same
  申请人：Eisai Co., Ltd.

  公开号：US04285941A1

  公开（公告）日：1981-08-25

  Novel cephalosporin compounds of the general formula: ##STR1## wherein R.sub.1 represents a substituted or unsubstituted nitrogen-containing heterocyclic-thio group, R.sub.2 represents hydrogen or hydroxy, and R.sub.3, R.sub.4 and R.sub.5 each represents hydrogen, hydroxy or acyloxy, and their salts, and processes for the preparation thereof. The novel compounds and their salts have antibacterial activity.

  一种新型头孢菌素化合物，其一般式为：##STR1## 其中R.sub.1代表取代或未取代的含氮杂环硫基，R.sub.2代表氢或羟基，R.sub.3、R.sub.4和R.sub.5分别代表氢、羟基或酰氧基，以及它们的盐，并提供制备它们的方法。这种新型化合物及其盐具有抗菌活性。
• 7-.alpha.-methoxycephalosporin derivatives, and antibacterial drugs
  申请人：Eisai Co., Ltd.

  公开号：US04344944A1

  公开（公告）日：1982-08-17

  Novel 7.alpha.-methoxycephalosporin derivatives, their pharmaceutically acceptable salts, process for the preparation thereof, and antibacterial drugs involving the derivative or salt. The derivatives or salts are effective against the Gram-positive bacteria and the Gram-negative bacteria.

  小说7.alpha.-甲氧基头孢菌素衍生物，其药用盐，其制备过程，以及包含该衍生物或盐的抗菌药物。该衍生物或盐对革兰氏阳性菌和革兰氏阴性菌均有效。