5-Methyl-3-propyl-1H-indazole | 110967-35-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡唑类
• 英文名称: 5-Methyl-3-propyl-1H-indazole
• 英文别名: 5-methyl-3-propyl-2H-indazole
• CAS: 110967-35-6
• 化学式: C₁₁H₁₄N₂
• 分子量: 174.24
• InChiKey: GRRFAHJFLWPDSG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  28.7
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  5-Methyl-3-propyl-1H-indazole 、 1,3-二溴丙烷 生成 7-methyl-5-propyl-2,3-dihydro-1H-pyrazolo[1,2-a]indazol-10-ium;bromide
  参考文献：
  名称：

  FUJIMURA YASUO; SHIRAKI YASUYUKI; NAWATA YOSHIHARU; MATSUNAGA ISAO, J. PHARM. SOC. JAP., 1986, 106, N 11, 1002-1007

  摘要：

  DOI：

文献信息

• Methods for treating cancer with RORγ inhibitors
  申请人：THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

  公开号：US10959984B2

  公开（公告）日：2021-03-30

  The present invention provides compositions, methods, and kits comprising one or more RORγ inhibitors, alone or in combination with one or more anticancer drugs, such as an anti-androgen drug, that are useful for treating cancer, e.g., prostate cancer, such as castration-resistant prostate cancer (CRPC), and numerous other types of cancer including lung cancer, breast cancer, liver cancer, ovarian cancer, endometrial cancer, bladder cancer, colon cancer, lymphoma, and glioma.

  本发明提供了包含一种或多种RORγ抑制剂的组合物、方法和试剂盒，单独或与一种或多种抗癌药物（如抗雄激素药物）联合使用，可用于治疗癌症，如前列腺癌，如阉割耐药前列腺癌（CRPC），以及许多其他类型的癌症，包括肺癌、乳腺癌、肝癌、卵巢癌、子宫内膜癌、膀胱癌、结肠癌、淋巴瘤和胶质瘤。
• METHODS FOR TREATING CANCER WITH RORGAMMA INHIBITORS
  申请人：THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

  公开号：US20180085348A1

  公开（公告）日：2018-03-29

  The present invention provides compositions, methods, and kits comprising one or more RORγ inhibitors, alone or in combination with one or more anticancer drugs, such as an anti-androgen drug, that are useful for treating cancer, e.g., prostate cancer, such as castration-resistant prostate cancer (CRPC), and numerous other types of cancer including lung cancer, breast cancer, liver cancer, ovarian cancer, endometrial cancer, bladder cancer, colon cancer, lymphoma, and glioma.
• FUJIMURA YASUO; SHIRAKI YASUYUKI; NAWATA YOSHIHARU; MATSUNAGA ISAO, J. PHARM. SOC. JAP., 1986, 106, N 11, 1002-1007
  作者：FUJIMURA YASUO、 SHIRAKI YASUYUKI、 NAWATA YOSHIHARU、 MATSUNAGA ISAO

  DOI：——

  日期：——