申请人:NISSAN CHEMICAL INDUSTRIES, LTD.
公开号:US20180200173A1
公开(公告)日:2018-07-19
A solid base material for external use on skin that has a breaking strength sufficiently high to be usable as a stick-shaped base material or the like. A solid base material for external use on skin containing a lipid peptide compound including at least one of compound of Formula (1), the similar compound thereof and the pharmacologically usable salts thereof; water; and a 1,3-alkanediol;
wherein R
1
is a C
9-23
aliphatic group; R
2
is a hydrogen atom or a C
1-4
alkyl group optionally having a C
1
or C
2
branched chain; and R
3
is a —(CH
2
)
n
—X group, wherein n is a number from 1 to 4, and X is amino group, guanidino group, -CONH
2
group, or a 5-membered ring group or 6-membered ring group optionally having one to three nitrogen atoms or a fused heterocyclic group composed of the 5-membered ring and the 6-membered ring.
一种用于外用于皮肤的固体基材料,其断裂强度足够高,可用作棒状基材料或类似物。一种用于外用于皮肤的固体基材料,包含一个脂肽化合物,其中至少包括公式(1)的化合物、类似的化合物及其药学可用的盐;水;和1,3-烷二醇;其中R1是C9-23脂肪基;R2是氢原子或C1-4烷基,可选地具有C1或C2支链;R3是—(CH2)n—X基团,其中n是1至4之间的数字,而X是氨基、鸟氨酸基、-CONH2基团或具有1至3个氮原子或由5-成员环和6-成员环组成的融合杂环基团中的5-成员环基团或6-成员环基团。