TMSOC6H5MeOMe | 219646-62-5

• 分子结构分类: 有机化合物 - 有机金属化合物 - 有机类金属化合物
• 英文名称: TMSOC6H5MeOMe
• 英文别名: (5-Methoxy-6-methylcyclohexa-1,5-dien-1-yl)oxy-trimethylsilane
• CAS: 219646-62-5
• 化学式: C₁₁H₂₀O₂Si
• 分子量: 212.364
• InChiKey: WMSHWERUYQADCV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.44
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  TMSOC6H5MeOMe 在 甲醇 、 偶氮二甲酸二异丙酯 、 三苯基膦 、 potassium hydroxide 作用下， 以 四氢呋喃 、 5,5-dimethyl-1,3-cyclohexadiene 为溶剂， 反应 25.0h， 生成
  参考文献：
  名称：

  Synthesis of a Series of Promising Isobenzofuranones for the Treatment of Acute Mucositis Caused by Chemo- and Radiotherapy

  摘要：

  A small series of 3,5-dihydroxy-7-methoxy-3,6-dimethylisobenzofuran-1(3H)-one analogues of the immunosuppressant, mycophenolate mofelite (MMF), has been identified during a screening campaign as possible mediators to prevent mucositis. Herein, we present a general seven-step approach for the preparation of small molecule mycophenolate mofelite analogues, which are readily available for further biological evaluation in our mucositis model.

  DOI：

  10.1055/s-0033-1340060
• 作为产物：
  描述：

  三甲基氯硅烷 、 3-methoxy-2-methylcyclohex-2-en-1-one 在 lithium diisopropyl amide 作用下， 以 四氢呋喃 为溶剂， 反应 1.17h， 生成 TMSOC6H5MeOMe
  参考文献：
  名称：

  Synthesis of Programmable Tetra-ortho-Substituted Biaryl Compounds Using Diels−Alder Cycloadditions/Cycloreversions of Disubstituted Alkynyl Stannanes

  摘要：

  Orthogonally functionalized, programmable biaryl templates have been synthesized utilizing aryl acetylenic stannanes and oxygenated dienes in a cycloaddition/cycloreversion strategy. Sequential functionalization of each of the four ortho positions has been demonstrated. Subsequent resolution of a representative anilino phenol has been accomplished. Additionally, a highly active anhydrous, boroxine-based Suzuki coupling protocol has been developed for conversion of unreactive aryl chlorides.

  DOI：

  10.1021/ja7113486