3-(trimethylacetyl)aminoanthracene-1,9-dicarboxylic acid anhydride | 294919-14-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 萘并吡喃类
• 英文名称: 3-(trimethylacetyl)aminoanthracene-1,9-dicarboxylic acid anhydride
• 英文别名: N-(14,16-dioxo-15-oxatetracyclo[7.7.1.02,7.013,17]heptadeca-1,7,9,11,13(17)-pentaen-11-yl)-2,2-dimethylpropanamide
• CAS: 294919-14-5
• 化学式: C₂₁H₂₁NO₄
• 分子量: 351.402
• InChiKey: PBTMBQGDNSFOTM-UHFFFAOYSA-N

物化性质

• 沸点：
  650.3±55.0 °C(Predicted)
• 密度：
  1.320±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  26
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  72.5
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3-(trimethylacetyl)aminoanthracene-1,9-dicarboxylic acid anhydride 在 盐酸 作用下， 以 乙醇 、 甲苯 为溶剂， 反应 44.0h， 生成 5-Amino-2-(2-dimethylamino-ethyl)-8,9,10,11-tetrahydro-dibenzo[de,h]isoquinoline-1,3-dione
  参考文献：
  名称：

  Analogues of Amonafide and Azonafide with Novel Ring Systems

  摘要：

  Three new types of amonafide and azonafide analogues were synthesized and screened in a panel of human solid tumor cells and murine L1210 leukemia cells. The structural types included tetrahydroazonafides, which have the naphthalene chromophore of amonafide within the anthracene nucleus of azonafide; phenanthrene analogues, in which the linear anthracene nucleus is replaced by the bent phenanthrene nucleus; and azaphenanthrenes. The tetrahydroazonafides were generally intermediate in potencies between amonafide and azonafide against the tumor cells, but some of them had high potencies against the L1210 cells and were more potent against the MDR strain than the sensitive strain. The phenanthrene and azaphenanthrene analogues showed no improvement on the potencies of the anthracenes.

  DOI：

  10.1021/jm9905817
• 作为产物：
  描述：

  1,2,7,8,9,10-hexahydro-4-<(trimethylacetyl)amino>cyclopentanoanthracene-1,2-dione 在 sodium hydroxide 、 双氧水 作用下， 以 1,4-二氧六环 为溶剂， 反应 1.0h， 生成 3-(trimethylacetyl)aminoanthracene-1,9-dicarboxylic acid anhydride
  参考文献：
  名称：

  Analogues of Amonafide and Azonafide with Novel Ring Systems

  摘要：

  Three new types of amonafide and azonafide analogues were synthesized and screened in a panel of human solid tumor cells and murine L1210 leukemia cells. The structural types included tetrahydroazonafides, which have the naphthalene chromophore of amonafide within the anthracene nucleus of azonafide; phenanthrene analogues, in which the linear anthracene nucleus is replaced by the bent phenanthrene nucleus; and azaphenanthrenes. The tetrahydroazonafides were generally intermediate in potencies between amonafide and azonafide against the tumor cells, but some of them had high potencies against the L1210 cells and were more potent against the MDR strain than the sensitive strain. The phenanthrene and azaphenanthrene analogues showed no improvement on the potencies of the anthracenes.

  DOI：

  10.1021/jm9905817

文献信息

• Analogues of Amonafide and Azonafide with Novel Ring Systems
  作者：Salah M. Sami、Robert T. Dorr、David S. Alberts、Anikó M. Sólyom、William A. Remers

  DOI：10.1021/jm9905817

  日期：2000.8.1

  Three new types of amonafide and azonafide analogues were synthesized and screened in a panel of human solid tumor cells and murine L1210 leukemia cells. The structural types included tetrahydroazonafides, which have the naphthalene chromophore of amonafide within the anthracene nucleus of azonafide; phenanthrene analogues, in which the linear anthracene nucleus is replaced by the bent phenanthrene nucleus; and azaphenanthrenes. The tetrahydroazonafides were generally intermediate in potencies between amonafide and azonafide against the tumor cells, but some of them had high potencies against the L1210 cells and were more potent against the MDR strain than the sensitive strain. The phenanthrene and azaphenanthrene analogues showed no improvement on the potencies of the anthracenes.