Phosphoric acid mono-{(3aR,4R,6R,6aR)-6-[8-bromo-1-((3aS,4R,6R,6aR)-2,2-dimethyl-6-phosphonooxymethyl-tetrahydro-cyclopenta[1,3]dioxol-4-yl)-6-oxo-1,6-dihydro-purin-9-yl]-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl} ester | 295805-75-3

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷酸
• 英文名称: Phosphoric acid mono-{(3aR,4R,6R,6aR)-6-[8-bromo-1-((3aS,4R,6R,6aR)-2,2-dimethyl-6-phosphonooxymethyl-tetrahydro-cyclopenta[1,3]dioxol-4-yl)-6-oxo-1,6-dihydro-purin-9-yl]-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl} ester
• 英文别名: [(3aS,4R,6R,6aR)-4-[9-[(3aR,4R,6R,6aR)-2,2-dimethyl-6-(phosphonooxymethyl)-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3]dioxol-4-yl]-8-bromo-6-oxopurin-1-yl]-2,2-dimethyl-4,5,6,6a-tetrahydro-3aH-cyclopenta[d][1,3]dioxol-6-yl]methyl dihydrogen phosphate
• CAS: 295805-75-3
• 化学式: C₂₂H₃₁BrN₄O₁₄P₂
• 分子量: 717.358
• InChiKey: YEMLFYGCDDBKNM-CXVOLFIRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2
• 重原子数：
  43
• 可旋转键数：
  8
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.77
• 拓扑面积：
  230
• 氢给体数：
  4
• 氢受体数：
  16

反应信息

• 作为反应物：
  描述：

  Phosphoric acid mono-{(3aR,4R,6R,6aR)-6-[8-bromo-1-((3aS,4R,6R,6aR)-2,2-dimethyl-6-phosphonooxymethyl-tetrahydro-cyclopenta[1,3]dioxol-4-yl)-6-oxo-1,6-dihydro-purin-9-yl]-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl} ester 在 1-(3-二甲基氨基丙基)-3-乙基碳二亚胺 作用下， 以 N-甲基吡咯烷酮 为溶剂， 以23%的产率得到
  参考文献：
  名称：

  细胞内Ca（2+）动员腺嘌呤核苷酸。腺苷A的环状ADP-碳环核糖和C-糖苷类似物的合成及其生物学活性。

  摘要：

  我们设计了新颖的Ca（2+）动员嘌呤核苷酸，环ADP-碳环核糖4，其肌苷同源物5和C-糖苷腺苷A6。在合成cADPR类似物时，分子内缩合形成焦磷酸酯键应为关键步骤。我们开发了一种通过用I2或AgNO3活化苯硫代磷酸酯基团来形成分子内焦磷酸酯键的有效方法。使用该方法，我们合成了目标化合物4和5。使用暂时的硅链自由基偶联反应来构建（3'alpha，1“ alpha）-C，可以合成腺磷素A的C-糖苷类似物6。 -糖苷结构为关键步骤。

  DOI：

  10.1081/ncn-100002320
• 作为产物：
  描述：

  5'-O-TBDMS-2',3'-O-isopropylidene-8-bromoinosine 在 四氮唑 、 四丁基氟化铵 、 碘 、 potassium carbonate 、 N,N-二异丙基乙胺 作用下， 以 乙二醇二甲醚 、 二氯甲烷 为溶剂， 生成 Phosphoric acid mono-{(3aR,4R,6R,6aR)-6-[8-bromo-1-((3aS,4R,6R,6aR)-2,2-dimethyl-6-phosphonooxymethyl-tetrahydro-cyclopenta[1,3]dioxol-4-yl)-6-oxo-1,6-dihydro-purin-9-yl]-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl} ester
  参考文献：
  名称：

  细胞内Ca（2+）动员腺嘌呤核苷酸。腺苷A的环状ADP-碳环核糖和C-糖苷类似物的合成及其生物学活性。

  摘要：

  我们设计了新颖的Ca（2+）动员嘌呤核苷酸，环ADP-碳环核糖4，其肌苷同源物5和C-糖苷腺苷A6。在合成cADPR类似物时，分子内缩合形成焦磷酸酯键应为关键步骤。我们开发了一种通过用I2或AgNO3活化苯硫代磷酸酯基团来形成分子内焦磷酸酯键的有效方法。使用该方法，我们合成了目标化合物4和5。使用暂时的硅链自由基偶联反应来构建（3'alpha，1“ alpha）-C，可以合成腺磷素A的C-糖苷类似物6。 -糖苷结构为关键步骤。

  DOI：

  10.1081/ncn-100002320

文献信息

• An Efficient Synthesis of Cyclic IDP- and Cyclic 8-Bromo-IDP-Carbocyclic-Riboses Using a Modified Hata Condensation Method To Form an Intramolecular Pyrophosphate Linkage as a Key Step. An Entry to a General Method for the Chemical Synthesis of Cyclic ADP-Ribose Analogues¹
  作者：Masayoshi Fukuoka、Satoshi Shuto、Noriaki Minakawa、Yoshihito Ueno、Akira Matsuda

  DOI：10.1021/jo0000877

  日期：2000.8.1

  An efficient synthesis of cyclic IDP-carbocyclic-ribose (3! and its 8-bromo derivative 6, as stable mimics of cyclic ADP-ribose, was achieved, and a condensation reaction with phenylthiophosphate-type substrate 15 or 16 to form an intramolecular pyrophosphate linkage was a key step. N-1-Carbocyclic-ribosylinosine derivative 28 and the corresponding 8-bromo congener 24 were prepared via condensation between N-1-(2,4-dinitrophenyl)inosine derivative 17 and a known optically active carbocyclic amine 18. Compounds 24 and 28 were then converted to the corresponding 5''-phosphoryl-5'-phenylthiophosphate derivatives 15 and 16, respectively, which were substrates for the condensation reaction to form an intramolecular pyrophosphate linkage. Treatment of 8-bromo substrate 15 with It or AgNO3 in the presence of molecular sieves 3A (MS 3A) in pyridine at room temperature gave the desired cyclic product 12 quantitatively, while the yield was quite low without MS. The similar reaction of 8-unsubstituted substrate 16 gave the corresponding cyclized product 32 in 81% yield. Acidic treatment of these cyclic pyrophosphates 12 and 32 readily gave the targets 6 and 3, respectively. This result suggests that the construction of N-1-substituted hypoxanthine nucleoside structures from N-1-(2, 4-dinitrophenyl)ino sine derivatives and the intramolecular condensation by activation of the phenylthiophosphate group with I-2 or AgNO3/MS 3A combine to provide a very efficient route for the synthesis of analogues of cyclic ADP-ribose such as 3 and 6. Thus, this may be an entry to a general method for synthesizing biologically important cyclic nucleotides of this type.