4-[4-(1-哌嗪基)苯基]吗啉 | 156605-79-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 中文名称: 4-[4-(1-哌嗪基)苯基]吗啉
• 英文名称: N-(4-N-Piperazinophenyl)morpholine
• 英文别名: 4-(4-Piperazin-1-ylphenyl)morpholine
• CAS: 156605-79-7
• 化学式: C₁₄H₂₁N₃O
• mdl: MFCD06797718
• 分子量: 247.34
• InChiKey: PHMRTDTVSRLPCU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.571
• 拓扑面积：
  27.7
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  吗啉 、 哌嗪 、 1,4-二氯苯 生成 4-[4-(1-哌嗪基)苯基]吗啉
  参考文献：
  名称：

  Studies on Selective Nucleophilic Substitution Reactions of [(Cyclopentadienyl)(1,3- and 1,4-dichlorobenzene)Fe]+PF6- Complexes: Applications to the Synthesis of Polymer Monomers

  摘要：

  Selective displacement of chloride from cyclopentadienyl(1,4-dichlorobenzene)iron(1+) by a series of aryl oxide and amine nucleophiles is described. The methodology, coupled with decomplexation of the product organometallics, allows access to a series of para-disubstituted benzene derivatives that are of potential value in the construction of unusual polymers. Four such compounds, derived from sequential addition of 4-hydroxybenzoic ester and hydroquinone or resorcinol monophenoxide to the 1,4- and 1,3-dichlorobenzene-FeCp complexes, were subjected to polyesterification reactions. Previously unreported isoregic poly(ether-esters) were-prepared and characterized.

  DOI：

  10.1021/jo00095a036

文献信息

• Therapeutically Active Thiazolo-Pyrimidine Derivatives
  申请人：UCB Pharma S.A.

  公开号：US20140315885A1

  公开（公告）日：2014-10-23

  A series of thiazolo[5,4-d]pyrimidine derivatives of formula (I) or an N-oxide thereof, or a pharmaceutically acceptable salt or solvate thereof: (I) Q represents a group of formula (Qa), (Qb), (Qc), (Qd) or (Qe) are beneficial in the treatment and/or prevention of various human ailments, including inflammatory, autoimmune and oncological disorders; viral diseases; and organ and cell transplant rejection.

  一系列噻唑并[5,4-d]嘧啶衍生物的化学式(I)或其N-氧化物，或其药用可接受的盐或溶剂：(I) Q代表化学式(Qa)、(Qb)、(Qc)、(Qd)或(Qe)的基团，在治疗和/或预防各种人类疾病方面具有益处，包括炎症性、自身免疫和肿瘤性疾病；病毒性疾病；以及器官和细胞移植排斥反应。
• Method for the preparation of substituted benzene derivatives
  申请人：H. Lundbeck A/S

  公开号：US20030040639A1

  公开（公告）日：2003-02-27

  A method for the preparation of selectively substituted benzene derivatives by application of solid phase synthesis is disclosed. In particular, the invention provides a novel method for the preparation of substituted benzene derivatives containing two or three groups bound to the benzene ring via nitrogen-, oxygen-, sulphur-, selenium- or carbon-carbon bonds, by application of solid phase chemistry alone or in combination with post cleavage solution phase derivatisation.

  本发明公开了一种通过应用固相合成的方法制备有选择性取代的苯衍生物。具体而言，本发明提供了一种新的方法，通过仅应用固相化学或与后解离溶液相衍生化合物相结合，制备含有通过氮、氧、硫、硒或碳-碳键与苯环结合的两个或三个基团的取代苯衍生物的方法。
• A METHOD FOR THE PREPARATION OF SUBSTITUTED BENZENE DERIVATIVES
  申请人：H. Lundbeck A/S

  公开号：EP1246819A1

  公开（公告）日：2002-10-09
• US9096614B2
  申请人：——

  公开号：US9096614B2

  公开（公告）日：2015-08-04
• USRE44205E1
  申请人：——

  公开号：USRE44205E1

  公开（公告）日：2013-05-07