cyclopentyltetrahydroisoquinoline | 1034071-73-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四氢异喹啉
• 英文名称: cyclopentyltetrahydroisoquinoline
• 英文别名: 1-Cyclopentyl-1,2,3,4-tetrahydroisoquinoline
• CAS: 1034071-73-2
• 化学式: C₁₄H₁₉N
• 分子量: 201.312
• InChiKey: GARMUJFIZOPCTN-UHFFFAOYSA-N

物化性质

• 沸点：
  321.3±11.0 °C(Predicted)
• 密度：
  1.034±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  cyclopentyltetrahydroisoquinoline 在 potassium carbonate 作用下， 以 水 、 乙腈 为溶剂， 反应 72.0h， 生成 1-(1-cyclopentyl-3,4-dihydroisoquinolin-2(1H)-yl)-2-{[(1-hydroxycyclohexyl)methyl]amino}ethanone oxalate
  参考文献：
  名称：

  发现一种1-异丙基四氢异喹啉衍生物作为神经性疼痛的口服活性N型钙通道阻滞剂。

  摘要：

  N型钙通道阻滞是一种治疗神经性疼痛的有前途的治疗方法。从铅化合物（S）-1开始，我们将优化工作的重点放在了抑制N型钙通道和改善CYP抑制谱上。2-{[（（1-羟基环己基）甲基]氨基}-（1 R）-（1-异丙基-6-甲氧基-3,4-二氢异喹啉-2（1 H）-基）乙酮乙二酸酯（（R）-5r）被确定为具有降低的CYP抑制作用的新型口服活性小分子N型钙通道抑制剂。口服（R）-5rED 50值为2.5 mg / kg的大鼠在神经性疼痛的脊髓神经结扎模型中改善了机械性异常性疼痛。

  DOI：

  10.1016/j.bmc.2015.05.030
• 作为产物：
  描述：

  cyclopentyl-3,4-dihydro-2(1H)-isochinolincarbaldehyd 在 乙醇 、 sodium hydroxide 作用下， 反应 3.0h， 生成 cyclopentyltetrahydroisoquinoline
  参考文献：
  名称：

  Facile synthesis and in vitro properties of 1-alkyl- and 1-alkyl-N-propargyl-1,2,3,4-tetrahydroisoquinoline derivatives on PC12 cells

  摘要：

  The synthesis of several 1-alkyl-1,2,3,4-tetrahydroisoquinolines, which may play an important role in Parkinson's disease, has been achieved by modified Pictet-Spengler cyclization of the formyliminium ion. The direct cytotoxicity and preventative effects towards MPP+-mediated death of PC12 cells were estimated. The cytotoxicities of 1-alkyl-TIQs were apoptotic and depended on their lipophilic properties. Conversely, introducing the N-propargyl substituent reduced cytotoxicity. 1-Methyl-, 1-methyl-N-propargyl- and 1-cyclopropyl-TIQ partially inhibited MPP+-induced cell death, whereas relatively large alkyl substituents at the first position did not enhance the viability of PC12 cells. In summary, our findings suggest a crucial role for the N-propargyl functional group for the effective reduction of cytotoxicity, and show the importance of size and lipophilicity of substituents at the 1-position of 1-alkyl TIQs. (C) 2009 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2009.04.035

文献信息

• Heterocyclic cyclopentyl tetrahydroisoquinoline and tetrahydropyridopyridine modulators of chemokine receptor activity
  申请人：Butora Gabor

  公开号：US20080081803A1

  公开（公告）日：2008-04-03

  The present invention is directed to compounds of the formula I: Wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , X, n and the broken lines are as defined herein which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptor CCR-2.

  本发明涉及以下式I的化合物： 其中R1、R2、R3、R4、R5、R6、R7、R8、R9、X、n和虚线如本文所定义，这些化合物可用作趋化因子受体活性的调节剂。特别地，这些化合物可用作趋化因子受体CCR-2的调节剂。
• Gastrointestinal tract detection methods, devices and systems
  申请人：Progenity Inc.

  公开号：US10610104B2

  公开（公告）日：2020-04-07

  The present disclosure relates to gastrointestinal (GI) tract detection methods, devices and systems.

  本公开涉及胃肠道（GI）检测方法、装置和系统。
• Treatment of a disease of the gastrointestinal tract with a chemokine/chemokine receptor inhibitor
  申请人：Progenity, Inc.

  公开号：US10980739B2

  公开（公告）日：2021-04-20

  This disclosure features methods and compositions for treating diseases of the gastrointestinal tract with a chemokine/chemokine receptor inhibitor.

  本公开的内容包括使用趋化因子/趋化因子受体抑制剂治疗胃肠道疾病的方法和组合物。
• Ingestible device for delivery of therapeutic agent to the gastrointestinal tract
  申请人：Progenity, Inc.

  公开号：US11007356B2

  公开（公告）日：2021-05-18

  An ingestible device, includes a storage reservoir configured to store a dispensable substance and a pressurized chamber configured so that, when a restraining force is removed from the pressurized chamber, the dispensable substance exits the ingestible device via openings in the ingestible device.

  一种可摄取装置，包括一个用于储存可分配物质的储存器和一个加压室，当从加压室移除限制力时，可分配物质通过可摄取装置上的开口排出可摄取装置。
• Ingestible device and associated methods
  申请人：Progenity Inc.

  公开号：US11224364B2

  公开（公告）日：2022-01-18

  An ingestible device is disclosed which can produce spectral data of one or more analytes, as well as associated methods for characterizing the gastrointestinal tract of a subject which contains such analytes. Related kits and systems are also disclosed.

  本研究公开了一种可摄取的装置，它可以产生一种或多种分析物的光谱数据，还公开了相关方法，用于描述含有这些分析物的受试者的胃肠道特征。还公开了相关的试剂盒和系统。