2-(4-Morpholin-4-ylphenyl)-1-phenylethanone | 884504-56-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 2-(4-Morpholin-4-ylphenyl)-1-phenylethanone
• CAS: 884504-56-7
• 化学式: C₁₈H₁₉NO₂
• 分子量: 281.3
• InChiKey: CVUANRYIBJFPSD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-(4-Morpholin-4-ylphenyl)-1-phenylethanone 、 2-肼基-5-溴吡啶 生成 5-bromo-3-(4-morpholin-4-ylphenyl)-2-phenyl-1H-pyrrolo[2,3-b]pyridine
  参考文献：
  名称：

  Substituted pyrrolopyridines

  摘要：

  提供了公式（I）的新化合物，其中R1、R2和R3如规范中定义，并且其药学上可接受的盐；以及它们的制备过程、含有它们的组合物和它们在治疗中的用途。这些化合物是Itk激酶的抑制剂。

  公开号：

  US20050261331A1

文献信息

• [EN] SUBSTITUTED PYRROLOPYRIDINES<br/>[FR] PYRROLOPYRIDINES SUBSTITUES
  申请人：ASTRAZENECA AB

  公开号：WO2004016609A1

  公开（公告）日：2004-02-26

  There are provided novel compounds of formula (I) wherein R1, R2 and R3 are as defined in the specification and pharmaceutically acceptable salts thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are inhibitors of the kinase Itk.

  提供了式(I)的新化合物，其中R1、R2和R3如规范中所定义，并且其药学上可接受的盐；以及它们的制备方法、含有它们的组合物以及它们在治疗中的用途。这些化合物是激酶Itk的抑制剂。
• Reactive plastisol dispersion
  申请人：W.R. GRACE & CO.

  公开号：EP0124812A1

  公开（公告）日：1984-11-14

  This invention relates to a reactive plastisol dispersion comprising (1) a polyvinyl acetal thermoplast in particle form; (2) a liquid plasticizer' member of the group consisting of (a) at least one an ethylenically unsaturated monomer, oligomer or prepolymer of the formula: wherein R is H or CH3, R1 is an organic moiety and n is 1 or more, (b) at least one unsaturated polyester containing the group: wherein R2 and R3 are organic moieties, x is 0-20 and y is 1-20; and (c) a mixture of (a) and (b); and, optionally, either (3) a free radical thermal initiator or (4) a photoinitiator for crosslinking. The reactive plastisol dispersion when fluxed can be useful as a sealant or adhesive.

  本发明涉及一种反应性塑溶胶分散体，包括 (1) 颗粒状的聚乙烯醇缩醛热塑性塑料； (2) 一种液态增塑剂，其组成成分如下 (a) 至少一种乙烯基不饱和单体、低聚物或预聚物，其式如下 其中 R 是 H 或 CH3，R1 是有机分子，n 是 1 或更多、 (b) 至少一种含有以下基团的不饱和聚酯： 其中 R2 和 R3 为有机分子，x 为 0-20，y 为 1-20；以及 (c) (a)和(b)的混合物；以及，任选其一 (3) 自由基热引发剂或 (4) 用于交联的光引发剂。 反应性塑溶胶分散体在助焊剂作用下可用作密封剂或粘合剂。
• Reactive plastisol
  申请人：W.R. GRACE & CO.

  公开号：EP0209658A2

  公开（公告）日：1987-01-28

  This invention relates to a thermosetting plastisol dispersion composition comprising (1) poly(phenylene oxide) (PPO) in powder form, which is insoluble in the reactive plasticizer at room temperature and plasticizable at a temperature at or above the fluxing temperature; (2) a liquid reactive plasticizer member of the group consisting of (a) at least one epoxide resin having an average of more than one epoxide group in the molecule, (b) at least one liquid monomer, oligomer or prepolymer containing at least one ethylenically unsaturated group and (c) a mixture of - (a) and (b); said liquid reactive plasticizer being capable of solvating the PPO at the fluxing temperature and being present in an amount ranging from 5 to 2,000 parts per 100 parts by weight of (1); and (3) 0.01 to 10% by weight of (2) of either a thermal initiator or photoinitiator for plasticizers present in the composition. The plastisol dispersion after fluxing can form a thermoset after the crosslinking reaction.

  本发明涉及一种热固性塑料溶胶分散体组合物，其中包括 (1) 粉末状聚环氧苯(PPO)，常温下不溶于活性增塑剂，在助熔温度或更高的温度下可增塑； (2) 一种液态活性增塑剂，属于以下组别：(a) 分子中平均含有一个以上环氧基团的 至少一种环氧树脂，(b) 含有至少一个乙烯不饱和基团的至少一种液态单体、 低聚物或预聚物，(c) (a)和(b)的混合物；所述液态活性增塑剂能在助熔温度下溶解 PPO，其含量为每 100 份（重量）(1) 含 5 至 2,000 份；以及 (3) 以重量计，(2)中的热引发剂或光引发剂占组合物中增塑剂的 0.01 至 10%。 经助焊剂处理后的塑料溶胶分散体可在交联反应后形成热固性塑料。
• Storage stable (meth)acrylate plastisols
  申请人：W.R. Grace & Co.-Conn.

  公开号：EP0219857A2

  公开（公告）日：1987-04-29

  This invention is directed to (meth)acrylic plastisols having storage stability at 40°C for at least 3 days and plasticizability at a temperature below 120°C in 5 minutes comprising (I) a poly(meth)acrylate in particle form, (2) a liquid plasticizer member of the group consisting of: (a) the reaction product of one mole of a polyether or polyester diol, two moles of a diisocyanate and two moles of a hydroxyalkyl - (meth)acrylate; (b) the reaction product of one mole of a polyester or polyether diol, two moles of a diacyl halide and two moles of a mono-alcohol; (c) the reaction product of one mole of a polyester or polyether diol, one mole of a diisocyanate, one mole of hydroxyalkyl (meth)-acrylate and one mole of an acyl halide; and (d) mixtures of (a), (b) and (c); and, optionally, either (3) a free radical thermal initiator, or (4) a photoinitiator. The piastisol dispersion after fluxing can form a sealant, coating or adhesive after the curing reaction.

  本发明涉及(甲基)丙烯酸塑溶胶，在 40°C 下具有至少 3 天的储存稳定性，在 120°C 以下的温度下 5 分钟内具有可塑化性。 (I) 颗粒形式的聚(甲基)丙烯酸酯、 (2) 由以下物质组成的液态增塑剂 (a) 一摩尔聚醚或聚酯二元醇、两摩尔二异氰酸酯和两摩尔羟烷基-(甲基)丙烯酸酯的反应产物； (b) 一摩尔聚酯或聚醚二元醇、两摩尔二酰卤和两摩尔一元醇的反应产物； (c) 一摩尔聚酯或聚醚二元醇、一摩尔二异氰酸酯、一摩尔(甲基)丙烯酸羟 烷酯和一摩尔酰卤的反应产物；以及 (d) (a)、(b)和(c)的混合物；以及任选一种 (3) 自由基热引发剂，或 (4) 光引发剂。 助焊后的 piastisol 分散体在固化反应后可形成密封剂、涂层或粘合剂。
• Uv or heat curable reinforced elastomer compositions
  申请人：W.R. Grace & Co.-Conn.

  公开号：EP0238863A2

  公开（公告）日：1987-09-30

  A radiation or heat cured elastomer is described which exhibits enhanced physical properties by virtue of its cure resulting in phase segregation.

  描述了一种辐射或热固化弹性体，这种弹性体因固化导致相分离而显示出更强的物理性能。