5-Methoxy-3-piperazin-1-yl-1-(toluene-4-sulfonyl)-1H-indazole | 921224-95-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 5-Methoxy-3-piperazin-1-yl-1-(toluene-4-sulfonyl)-1H-indazole
• 英文别名: 5-Methoxy-1-(4-methylbenzene-1-sulfonyl)-3-(piperazin-1-yl)-1H-indazole；5-methoxy-1-(4-methylphenyl)sulfonyl-3-piperazin-1-ylindazole
• CAS: 921224-95-5
• 化学式: C₁₉H₂₂N₄O₃S
• 分子量: 386.475
• InChiKey: RMBTZWWFHWUBJJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  84.8
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  5-Methoxy-3-piperazin-1-yl-1-(toluene-4-sulfonyl)-1H-indazole 、 氯甲酸苄酯 在 tetrapropylammonium L-prolinate 作用下， 反应 10.0h， 以95%的产率得到4-[5-Methoxy-1-(toluene-4-sulfonyl)-1H-indazol-3-yl]-piperazine-1-carboxylic acid benzyl ester
  参考文献：
  名称：

  N-Benzyloxycarbonylation of amines in the ionic liquid [TPA][l-Pro] as an efficient reaction medium

  摘要：

  An efficient method for the N-benzyloxycarbonylation of amines is described. The reaction of amines with Cbz-Cl in the ionic liquid [TPA][L-Pro] afforded the corresponding N-Cbz derivatives in excellent yields. The method is versatile for the preparation of a wide variety of N-Cbz derivatives of aliphatic and aromatic amines. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.02.108

文献信息

• A mild and efficient chemoselective protection of amines as N-benzyloxycarbonyl derivatives in the presence of La(NO3)3·6H2O under solvent-free conditions
  作者：K. Chinni Mahesh、M. Narasimhulu、T. Srikanth Reddy、N. Suryakiran、Y. Venkateswarlu

  DOI：10.1016/j.tetlet.2006.11.015

  日期：2007.1

  A facile and versatile method for the chemoselective N-benzyloxycarbonylation of amines has been developed by treatment with benzyloxycarbonyl chloride (Cbz-Cl) in the presence of lanthanum(III) nitrate hexahydrate under solvent-free conditions. The method is general for the preparation of N-Cbz derivatives of aliphatic (acyclic and cyclic) and aromatic amines. (c) 2006 Elsevier Ltd. All rights reserved.
• N-Benzyloxycarbonylation of amines in the ionic liquid [TPA][l-Pro] as an efficient reaction medium
  作者：N. Suryakiran、K. Chinni Mahesh、D. Ramesh、J. Jon Paul Selvam、Y. Venkateswarlu

  DOI：10.1016/j.tetlet.2008.02.108

  日期：2008.4

  An efficient method for the N-benzyloxycarbonylation of amines is described. The reaction of amines with Cbz-Cl in the ionic liquid [TPA][L-Pro] afforded the corresponding N-Cbz derivatives in excellent yields. The method is versatile for the preparation of a wide variety of N-Cbz derivatives of aliphatic and aromatic amines. (C) 2008 Elsevier Ltd. All rights reserved.