4-(3-methyl-butyl)-piperazin-1-ylamine | 56964-25-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 4-(3-methyl-butyl)-piperazin-1-ylamine
• 英文别名: N-(3-methylbutyl)-N'-amino-piperazine；4-(3-Methylbutyl)piperazin-1-amine
• CAS: 56964-25-1
• 化学式: C₉H₂₁N₃
• mdl: MFCD18810826
• 分子量: 171.286
• InChiKey: RYGFOOLIPWKURO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  32.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-(3-methyl-butyl)-piperazin-1-ylamine 、 3-Formyl Rifamycin 以 四氢呋喃 为溶剂， 反应 0.25h， 生成
  参考文献：
  名称：

  Cricchio; Arioli; Lancini, Farmaco, Edizione Scientifica, 1975, vol. 30, # 8, p. 605 - 619

  摘要：

  DOI：
• 作为产物：
  描述：

  1-(3-甲基丁基)-4-亚硝基-哌嗪 以 四氢呋喃 为溶剂， 生成 4-(3-methyl-butyl)-piperazin-1-ylamine
  参考文献：
  名称：

  Benzamide derivatives

  摘要：

  一种具有以下结构的化合物及其药用盐：其中：R.sub.1是C.sub.1-6烷氧基；R.sub.2和R.sub.3相同或不同，可以是氢、卤素、CF.sub.3、羟基、C.sub.1-6烷氧基、C.sub.2-7酰基、氨基、氨基，氨基上取代一个或两个C.sub.1-6烷基、C.sub.2-10酰胺基、氨基磺酰基、氨基磺酰基上取代一个或两个C.sub.1-6烷基、C.sub.1-6烷基磺酰基或硝基；A是C.sub.2-4烷基基团；R.sub.5和R.sub.6连接在一起，与它们连接的--N--A--N--基团形成6、7或8元杂环环；R.sub.7是C.sub.1-6烷基，或芳基--C.sub.1-6烷基，其中烷基部分可选择地被C.sub.1-6烷基或芳基取代；具有有用的药理活性，例如调节胃肠功能和治疗呕吐。

  公开号：

  US04267175A1

文献信息

• [EN] USE OF PYRIDYLOXYPYRIMIDINES FOR TREATING INFECTIOUS DISEASES<br/>[FR] UTILISATION DE PYRIDYLOXYPYRIMIDINES DANS LE TRAITEMENT DE MALADIES INFECTIEUSES
  申请人：BP ASSET V INC

  公开号：WO2021097002A1

  公开（公告）日：2021-05-20

  Provided herein are methods of treating a viral infection in a subject in need thereof, comprising administering to the subject a compound of Formula (I), or a pharmaceutical composition comprising Formula (I). Further provided herein are methods for inhibiting the replication of a virus (e.g., a togaviridae family virus (e.g., an alphavirus (e.g., Chikungunya virus, eastern equine encephalitis, mayaro virus, Venezuelan equine encephalitis virus, western equine encephalitis)), a filoviradae family virus (e.g., a Marburgvirus (e.g., Marburg virus, Ravn virus)), human respiratory syncytial virus (i.e., human orthopneumo virus ), a flavivirus (e.g., dengue virus, Usutu virus, Japanese encephalitis virus, Powassan virus, yellow fever), a paramyxoviridae family virus (e.g., an orthoparamyxovirinae virus (e.g., a henipavims (e.g., Nipah virus), a morbillivims (e.g., measles morbillivirus))) in a subject in need thereof. Also provided herein are methods for treating and/or preventing a disorder due to a microbial toxin (e.g., due to P. aeruginosa exotoxin A, Clostridium septicum alpha-toxin, diphtheria toxin(s), shiga toxin(s)) in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of Formula (I), or a pharmaceutical composition comprising a compound of Formula (I) as described herein. Also provided are pharmaceutical compositions and kits including a compound of Formula (I) for use in the treatment and/or prevention of a viral infection in a subject in need thereof.

  在此提供了治疗需要的受试者病毒感染的方法，包括向受试者给予式(I)的化合物或包含式(I)的药物组合物。此外，在此提供了抑制病毒复制的方法（例如togaviridae家族病毒（例如alphavirus（例如Chikungunya病毒，东部马脑炎，Mayaro病毒，委内瑞拉马脑炎病毒，西部马脑炎） ，filoviradae家族病毒（例如Marburgvirus（例如Marburg病毒，Ravn病毒）），人类呼吸道合胞病毒（即人类正式肺炎病毒），黄病毒等），以及需要的受试者中的微生物毒素引起的疾病的治疗和/或预防方法（例如由P. aeruginosa外毒素A，Clostridium septicum alpha-toxin，白喉毒素，志贺毒素引起的疾病），包括向受试者给予式(I)的化合物的治疗有效量或包含此处所述的式(I)的药物组合物。还提供了用于治疗和/或预防需要的受试者病毒感染的式(I)的化合物的药物组合物和工具包。
• US4267175A
  申请人：——

  公开号：US4267175A

  公开（公告）日：1981-05-12
• [EN] FURIN INHIBITORS FOR TREATING CORONAVIRUS INFECTIONS<br/>[FR] INHIBITEURS DE FURINE POUR TRAITER DES INFECTIONS À CORONAVIRUS
  申请人：BP ASSET V INC

  公开号：WO2021202874A1

  公开（公告）日：2021-10-07

  Provided herein are methods, pharmaceutical compositions, and kits for treating and/or preventing a viral infection resulting from a coronaviridae family virus in a subject in need thereof, comprising administering to the subject a compound of Formula (I), or a pharmaceutical composition comprising a compound of Formula (I). Further provided herein are methods for inhibiting the viral entry into a cell of a coronaviridae family virus (e.g., alphacoronavirus (e.g., HCoV-NL63, HCoV-229E), betacoronavirus (e.g., SARS-CoV, SARS-CoV-2, MERS-CoV, HCoV-OC43, HCoV-HKUl)) in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of Formula (I), or a pharmaceutically acceptable salt thereof, or a pharmaceutical composition comprising a compound of Formula (I) as described herein. Also provided are pharmaceutical compositions and kits comprising a compound of Formula (I), or a pharmaceutically acceptable salt thereof, for use in the treatment and/or prevention of a viral infection resulting from a coronaviridae family virus in a subject in need thereof.
• Cricchio; Arioli; Lancini, Farmaco, Edizione Scientifica, 1975, vol. 30, # 8, p. 605 - 619
  作者：Cricchio、Arioli、Lancini

  DOI：——

  日期：——
• Benzamide derivatives
  申请人：Beecham Group Limited

  公开号：US04267175A1

  公开（公告）日：1981-05-12

  A compound of the formula (I), and pharmaceutically acceptable salts thereof: ##STR1## wherein: R.sub.1 is a C.sub.1-6 alkoxy group; R.sub.2 and R.sub.3 are the same or different and are hydrogen, halogen, CF.sub.3, hydroxy, C.sub.1-6 alkoxy, C.sub.2-7 acyl, amino, amino substituted by one or two C.sub.1-6 alkyl groups, C.sub.2-10 acyl amino, aminosulphone, aminosulphone substituted by one or two C.sub.1-6 alkyl groups, C.sub.1-6 alkyl sulphone or nitro groups; and A is a C.sub.2-4 alkylene group; R.sub.5 and R.sub.6 are joined so that they form with the --N--A--N-- group to which they are attached, a 6, 7 or 8 membered heterocyclic ring; R.sub.7 is a C.sub.1-6 alkyl group, or an aryl --C.sub.1-6 akyl group in which the alkyl moiety is optionally substituted by a C.sub.1-6 alkyl or aryl group; have useful pharmacological activity, such as the ability to regulate the gastrointestinal function and to treat emesis.

  一种具有以下结构的化合物及其药用盐：其中：R.sub.1是C.sub.1-6烷氧基；R.sub.2和R.sub.3相同或不同，可以是氢、卤素、CF.sub.3、羟基、C.sub.1-6烷氧基、C.sub.2-7酰基、氨基、氨基，氨基上取代一个或两个C.sub.1-6烷基、C.sub.2-10酰胺基、氨基磺酰基、氨基磺酰基上取代一个或两个C.sub.1-6烷基、C.sub.1-6烷基磺酰基或硝基；A是C.sub.2-4烷基基团；R.sub.5和R.sub.6连接在一起，与它们连接的--N--A--N--基团形成6、7或8元杂环环；R.sub.7是C.sub.1-6烷基，或芳基--C.sub.1-6烷基，其中烷基部分可选择地被C.sub.1-6烷基或芳基取代；具有有用的药理活性，例如调节胃肠功能和治疗呕吐。