(2-diisopropylamino-ethyl)-urea | 98958-54-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机碳酸及其衍生物
• 英文名称: (2-diisopropylamino-ethyl)-urea
• 英文别名: (2-Diisopropylamino-aethyl)-harnstoff；2-[Di(propan-2-yl)amino]ethylurea
• CAS: 98958-54-4
• 化学式: C₉H₂₁N₃O
• mdl: MFCD09810080
• 分子量: 187.285
• InChiKey: LTJDVNNSDGPINV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  13
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.888
• 拓扑面积：
  58.4
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (2-diisopropylamino-ethyl)-urea 、 联苯甲酰 在 氢氧化钾 作用下， 生成 3-(2-diisopropylamino-ethyl)-5,5-diphenyl-imidazolidine-2,4-dione
  参考文献：
  名称：

  Chiti; Selleri, Farmaco, Edizione Scientifica, 1958, vol. 13, p. 261,282

  摘要：

  DOI：
• 作为产物：
  描述：

  potassium cyanate 、 alkaline earth salt of/the/ methylsulfuric acid 在 氢氧化钾 、 水 作用下， 生成 (2-diisopropylamino-ethyl)-urea
  参考文献：
  名称：

  Chiti; Selleri, Farmaco, Edizione Scientifica, 1958, vol. 13, p. 261,282

  摘要：

  DOI：

文献信息

• Organic Compounds
  申请人：Fairhurst Robin Alec

  公开号：US20100286126A1

  公开（公告）日：2010-11-11

  A compound of formula (I) or stereoisomers or pharmaceutically acceptable salts thereof, and their preparation and use as pharmaceuticals wherein R 1 , R 2 and R 3 are as defined herein.

  化合物的公式（I）或其立体异构体或药用可接受的盐，以及它们的制备和用途作为药物，其中R1、R2和R3如本文所定义。
• 2-AMINOCARBONYL-9H-PURINE DERIVATIVES
  申请人：Pfizer Limited

  公开号：EP1292604B1

  公开（公告）日：2009-05-13
• COMBINATION OF AN ADENOSINE A2A-RECEPTOR AGONIST AND TIOTROPIUM OR A DERIVATIVE THEREOF FOR TREATING OBSTRUCTIVE AIRWAYS
  申请人：Boehringer Ingelheim Pharma GmbH & Co.KG

  公开号：EP1397140A2

  公开（公告）日：2004-03-17
• AN ADENOSINE A2A RECEPTOR AGONIST AND AN ANTICHOLINERGIC AGENT IN COMBINATION FOR TREATING OBSTRUCTIVE AIRWAYS DISEASES
  申请人：PFIZER INC.

  公开号：EP1395287A1

  公开（公告）日：2004-03-10
• [EN] COMBINATION OF AN ADENOSINE A2A-RECEPTOR AGONIST AND TIOTROPIUM OR A DERIVATIVE THEREOF FOR TREATING OBSTRUCTIVE AIRWAYS AND OTHER INFLAMMATORY DISEASES<br/>[FR] COMBINAISON D'AGONISTE VIS-A-VIS DU RECEPTEUR DE L'ADENOSINE A2A-ET DE TIOTROPIUM OU DE DERIVE DE CETTE SUBSTANCE, POUR LE TRAITEMENT DE L'OBSTRUCTION DES VOIES RESPIRATOIRES ET D'AUTRES MALADIES INFLAMMATOIRES
  申请人：BOEHRINGER INGELHEIM PHARMA

  公开号：WO2002094273A2

  公开（公告）日：2002-11-28

  A combination of therapeutic agents useful in the treatment of obstructive airways and other inflammatory diseases comprising (i) an adenosine A2 receptor agonist; and (ii) an anti-cholinergic agent, preferably comprising a member selected from the group consisting of tiotropium and derivatives thereof; the combination being therapeutically effective in the treatment of the diseases when administered by inhalation; as well as to a method of treating the obstructive airways and other inflammatory diseases comprising administering separately, simultaneously or sequentially to the mammal by inhalation a therapeutically effective amount of the combination of therapeutic agents; as well as to a pharmaceutical composition comprising a pharmaceutically acceptable carrier together with the combination of therapeutic agents; as well as to a product containing the compounds of the combination for separate, simultaneous or sequential administration by inhalation to a mammal for the treatment of obstructive airways and other inflammatory diseases. It is preferred that the anti-cholinergic agent component be tiotropium bromide.