4-(3-methyl-[2]naphthyl)-butyric acid | 108122-89-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 4-(3-methyl-[2]naphthyl)-butyric acid
• 英文别名: 4-(3-Methyl-[2]naphthyl)-buttersaeure；4-(3-Methylnaphthalen-2-yl)butanoic acid
• CAS: 108122-89-0
• 化学式: C₁₅H₁₆O₂
• 分子量: 228.291
• InChiKey: STFUMWHOLQKHBU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4-(3-甲基-5,6,7,8-四氢-[2]萘基)-丁酸 在 palladium on activated charcoal 作用下， 生成 4-(3-methyl-[2]naphthyl)-butyric acid
  参考文献：
  名称：

  Moyle; Ritchie, Australian Journal of Chemistry, 1958, vol. 11, p. 211,220

  摘要：

  DOI：

文献信息

• Therapeutic compounds and methods
  申请人：UNIVERSITY OF TASMANIA

  公开号：US10934253B2

  公开（公告）日：2021-03-02

  The invention relates to compounds of Formula (I) and methods for their preparation. Also described are pharmaceutical compositions comprising a compound of Formula (I) and their use in the treatment or prevention of conditions associated with mitochondrial dysfunction. Formula (I)

  本发明涉及式（I）化合物及其制备方法。还描述了包含式（I）化合物的药物组合物及其在治疗或预防线粒体功能障碍相关疾病中的用途。式 (I)
• THERAPEUTIC COMPOUNDS AND METHODS
  申请人：UNIVERSITY OF TASMANIA

  公开号：US20200131119A1

  公开（公告）日：2020-04-30

  The invention relates to compounds of Formula (I) and methods for their preparation. Also described are pharmaceutical compositions comprising a compound of Formula (I) and their use in the treatment or prevention of conditions associated with mitochondrial dysfunction. Formula (I)