2-(3-(3-aminopropoxy)-2-naphthamido)-5-chlorophenyl 3-(3-aminopropoxy)-2-naphthoate | 1224678-73-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-(3-(3-aminopropoxy)-2-naphthamido)-5-chlorophenyl 3-(3-aminopropoxy)-2-naphthoate
• 英文别名: [2-[[3-(3-Aminopropoxy)naphthalene-2-carbonyl]amino]-5-chlorophenyl] 3-(3-aminopropoxy)naphthalene-2-carboxylate
• CAS: 1224678-73-2
• 化学式: C₃₄H₃₂ClN₃O₅
• 分子量: 598.098
• InChiKey: AIPZUMFOUJCOBM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  43
• 可旋转键数：
  13
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  126
• 氢给体数：
  3
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  2-(3-(3-aminopropoxy)-2-naphthamido)-5-chlorophenyl 3-(3-aminopropoxy)-2-naphthoate 以 aq. phosphate buffer 为溶剂， 以50%的产率得到C₃₄H₃₂ClN₃O₅
  参考文献：
  名称：

  [EN] PHARMACEUTICAL COMPOSITIONS COMPRISING NAPTHAMIDES
  [FR] COMPOSITIONS PHARMACEUTIQUES COMPRENANT DES NAPTHAMIDES

  摘要：

  本文披露了含有两个双环基团的萘酰胺和喹啉羧酰胺化合物，包括这些化合物的药物组合物以及使用这些组合物治疗由环磷酸腺苷（cAMP）响应元件结合蛋白（CREB）介导的癌症的方法。所披露的组合物在治疗人体主体的肺癌、前列腺癌和乳腺癌方面具有实用性。

  公开号：

  WO2013067379A1

文献信息

• [EN] NAPHTHAMIDES AS ANTICANCER AGENTS<br/>[FR] NAPHTHAMIDES EN TANT QU'AGENTS ANTI-CANCÉREUX
  申请人：UNIV OREGON HEALTH & SCIENCE

  公开号：WO2010048302A1

  公开（公告）日：2010-04-29

  A compound (particularly useful for inhibiting cancer) according to formula (I): or a pharmaceutically acceptable salt thereof, wherein: x is 0 or 1; R1-R6 are each independently H, -CN, -NO2, -NO, -OH, halogen, hydroxyalkyl, carboxyl, substituted carboxyl, aminocarbonyl, alkoxy, carbonyl or substituted carbonyl; R7 is H, alkyl, alkyl amino, aminoacyl, hydroxyacyl, heteroaryl, heterocycloalkyi, alkyl heteroaryl or alkyl heterocycloalkyl; R8 is H or alkyl; A is O or N; and Ar is an aryl, substituted aryl, heteroaryl, or substituted heleroaryl, provided that if R7 is H then Ar is aryl substituted with alkyl amino.

  一种化合物（特别适用于抑制癌症），其化学式为（I）或其药学上可接受的盐，其中：x为0或1；R1-R6各自独立地为H，-CN，-NO2，-NO，-OH，卤素，羟基烷基，羧基，取代羧基，氨基甲酰基，烷氧基，羰基或取代羰基；R7为H，烷基，烷基氨基，氨基酰基，羟基酰基，杂环芳基，杂环环烷基，烷基杂环芳基或烷基杂环环烷基；R8为H或烷基；A为O或N；Ar为芳基，取代芳基，杂环芳基或取代杂环芳基，但如果R7为H，则Ar为取代烷基氨基的芳基。
• PHARMACEUTICAL COMPOSITIONS COMPRISING NAPTHAMIDES
  申请人：Xiao Xiangshu

  公开号：US20140336262A1

  公开（公告）日：2014-11-13

  Disclosed herein are naphthamide and quinoline carboxamide compounds containing two bicyclic moieties, pharmaceutical compositions comprising those compounds and methods of using the compositions in the treatment of cancers mediated by cyclic-AMP (cAMP) response element binding protein (CREB). The disclosed compositions have utility in the treatment of lung, prostate and breast cancers in a human subject.
• SYNERGISTIC INHIBITORS OF CREB-MEDIATED GENE TRANSCRIPTION
  申请人：OREGON HEALTH & SCIENCE UNIVERSITY

  公开号：US20220387359A1

  公开（公告）日：2022-12-08

  Disclosed herein are uses for a compound of Formula (I), below, or a pharmaceutically acceptable salt thereof: wherein n is an integer selected from the group of 0, 1, 2, 3, and 4, or a pharmaceutically acceptable salt thereof, for enhancing the effect of an anti-cancer agent, such as an inhibitor of CREB-mediated gene transcription.
• US8653086B2
  申请人：——

  公开号：US8653086B2

  公开（公告）日：2014-02-18
• US9073820B2
  申请人：——

  公开号：US9073820B2

  公开（公告）日：2015-07-07