1-(Cyclohexyl-1,2-t2)-4-[3-(1,2,3,4-tetrahydro-5-methoxy-1-naphthalenyl)propyl]piperazine | 1025097-20-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: 1-(Cyclohexyl-1,2-t2)-4-[3-(1,2,3,4-tetrahydro-5-methoxy-1-naphthalenyl)propyl]piperazine
• 英文别名: 1-(1,2-ditritiocyclohexyl)-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine
• CAS: 1025097-20-4
• 化学式: C₂₄H₃₈N₂O
• 分子量: 374.563
• InChiKey: PHRCDWVPTULQMT-FHRYYMBBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  15.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1-(1-cyclohexenyl)-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)-n-propyl]piperazine 在 sodium borotritide 作用下， 以100%的产率得到1-(Cyclohexyl-1,2-t2)-4-[3-(1,2,3,4-tetrahydro-5-methoxy-1-naphthalenyl)propyl]piperazine
  参考文献：
  名称：

  Tritium radiolabelling of PB28, a potent sigma-2 receptor ligand: pharmacokinetic and pharmacodynamic characterization

  摘要：

  A potent sigma-2 receptor ligand, known as PB28, was tritium radiolabelled and biologically evaluated. The results showed that [H-3]PB28 and the corresponding unlabelled PB28 had superimposed pharmacodynamic properties. This radioligand appears as a potential candidate for receptor binding and in living cells assays. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.12.056

文献信息

• Tritium radiolabelling of PB28, a potent sigma-2 receptor ligand: pharmacokinetic and pharmacodynamic characterization
  作者：Nicola Antonio Colabufo、Carmen Abate、Marialessandra Contino、Carmela Inglese、Savina Ferorelli、Francesco Berardi、Roberto Perrone

  DOI：10.1016/j.bmcl.2007.12.056

  日期：2008.3

  A potent sigma-2 receptor ligand, known as PB28, was tritium radiolabelled and biologically evaluated. The results showed that [H-3]PB28 and the corresponding unlabelled PB28 had superimposed pharmacodynamic properties. This radioligand appears as a potential candidate for receptor binding and in living cells assays. (C) 2007 Elsevier Ltd. All rights reserved.