{2-[(5-Bromo-pyridin-3-yl)-(naphthalene-2-sulfonyl)-amino]-ethyl}-carbamic Acid Tert-Butyl Ester | 552332-40-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: {2-[(5-Bromo-pyridin-3-yl)-(naphthalene-2-sulfonyl)-amino]-ethyl}-carbamic Acid Tert-Butyl Ester
• 英文别名: [2-[(5-Bromo-3-pyridinyl)(2-naphthalenylsulfonyl)amino]ethyl]carbamic acid 1,1-dimethylethyl ester；tert-butyl N-[2-[(5-bromopyridin-3-yl)-naphthalen-2-ylsulfonylamino]ethyl]carbamate
• CAS: 552332-40-8
• 化学式: C₂₂H₂₄BrN₃O₄S
• 分子量: 506.42
• InChiKey: JBMVIBHXKXXKST-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  31
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  97
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  tert-butyl (2-((5-bromopyridin-3-yl)amino)ethyl)carbamate 、 2-萘磺酰氯 在 吡啶 、 乙酸乙酯 、 正己烷 、 desired product 作用下， 以 吡啶 为溶剂， 反应 15.0h， 生成 {2-[(5-Bromo-pyridin-3-yl)-(naphthalene-2-sulfonyl)-amino]-ethyl}-carbamic Acid Tert-Butyl Ester
  参考文献：
  名称：

  Kinase inhibitors

  摘要：

  具有公式的化合物对于抑制蛋白激酶很有用。还公开了抑制蛋白激酶的组合物和在患者中抑制蛋白激酶的方法。

  公开号：

  US06831175B2

文献信息

• OXAZOLIDINONE DERIVATIVES AS POTENTIAL ANTIMICROBIALS
  申请人：RANBAXY LABORATORIES, LTD.

  公开号：EP1409464A1

  公开（公告）日：2004-04-21
• 3-(PHENYL-ALKOXY)-5-(PHENYL)-PYRIDINE DERIVATIVES AND RELATED COMPOUNDS AS KINASE INHIBITORS FOR THE TREATMENT OF CANCER
  申请人：Abbott Laboratories

  公开号：EP1463505A2

  公开（公告）日：2004-10-06
• US6831175B2
  申请人：——

  公开号：US6831175B2

  公开（公告）日：2004-12-14
• [EN] OXAZOLIDINONE DERIVATIVES AS POTENTIAL ANTIMICROBIALS<br/>[FR] DERIVES D'OXAZOLIDINONE UTILISES COMME ANTIMICROBIENS POTENTIELS
  申请人：RANBAXY LAB LTD

  公开号：WO2003008389A1

  公开（公告）日：2003-01-30

  The present invention relates to certain substituted phenyl oxazolidinones and to processes for the synthesis of the same. This invention also relates to pharmaceutical compositions containing the compounds of the present invention as antimicrobials. The compounds are useful antimicrobial agents, effective against a number of human and veterinary pathogens, including gram-positive aerobic bacteria such as multiply-resistant staphylococci, streptococci and enterococci as well as anaerobic organisms such as Bacteroides spp. and Clostridium spp. species, and acid fast organisms such as Mycobacterium tuberculosis, Mycobacterium avium and Mycobacterium spp.
• [EN] KINASE INHIBITORS<br/>[FR] INHIBITEURS DE KINASE
  申请人：ABBOTT LAB

  公开号：WO2003051366A2

  公开（公告）日：2003-06-26

  Compounds having the formula (I), are useful for inhibiting protein kinases and for the treatment of cancer. Also disclosed are compositions which inhibit protein kinases and methods of inhibiting protein kinases in a patient.