5-[(aminocarbonyl)amino]thiophene-2,4-dicarboxamide | 869093-03-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩类
• 英文名称: 5-[(aminocarbonyl)amino]thiophene-2,4-dicarboxamide
• 英文别名: 5-(Carbamoylamino)thiophene-2,4-dicarboxamide
• CAS: 869093-03-8
• 化学式: C₇H₈N₄O₃S
• 分子量: 228.232
• InChiKey: KOEALWKKPTUGTG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.8
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  170
• 氢给体数：
  4
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-[(氨基羰基)氨基]-5-溴-3-噻吩羧酰胺 在 1,1'-双(二苯基膦)二茂铁 、 tris-(dibenzylideneacetone)dipalladium(0) 甲醇 、 sodium hydroxide 、 水 、 氰化锌 作用下， 以 DMF (N,N-dimethyl-formamide) 、 苯甲腈 为溶剂， 反应 6.0h， 生成 5-[(aminocarbonyl)amino]thiophene-2,4-dicarboxamide
  参考文献：
  名称：

  [EN] SUBSTITUTED THIOPHENE AMIDE COMPOUNDS FOR THE TREATMENT OF INFLAMMATION
  [FR] COMPOSES D'AMIDE A SUBSTITUTION DE THIOPHENE POUR LE TRAITEMENT DE L'INFLAMMATION.

  摘要：

  公式I中抑制IKK-2的化合物：其中R、X、Y、Z、R3、R4、R5如本文所定义。

  公开号：

  WO2005105777A1

文献信息

• SULFOXIDE AND BIS-SULFOXIDE COMPOUNDS AND COMPOSITIONS FOR CHOLESTEROL MANAGEMENT AND RELATED USES
  申请人：Esperion Therapeutics Inc.

  公开号：EP1366024A2

  公开（公告）日：2003-12-03
• [EN] SULFOXIDE AND BIS-SULFOXIDE COMPOUNDS AND COMPOSITIONS FOR CHOLESTEROL MANAGEMENT AND RELATED USES<br/>[FR] COMPOSES DE SULFOXYDE ET DE BIS-SULFOXYDE ET COMPOSITIONS POUR REGULER LE CHOLESTEROL, ET APPLICATIONS ASSOCIEES
  申请人：ESPERION THERAPEUTICS INC

  公开号：WO2002030882A2

  公开（公告）日：2002-04-18

  The present invention relates to sulfoxide and bis-sulfoxide compounds of formula I, formula II, or formula III (in which the variables are as defined in the claims), compositions comprising sulphoxide and bissulphoxide compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders comprising administering a composition comprising an ether compound. The compounds, compositions, and methods of the invention are also useful for treating and preventing Alzheimer's Disease, Syndrome X, peroxisome proliferator activated receptor-related disorders, septicemia, thrombotic disorders, obesity, pancreatitis, hypertension, renal disease, cancer inflammation, and impotence. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.
• [EN] SULFOXIDE AND BIS-SULFOXIDE COMPOUNDS AND COMPOSITIONS FOR CHOLESTEROL MANAGEMENT AND RELATED USES<br/>[FR] COMPOSES DE SULFOXYDE ET DE BIS-SULFOXYDE, ET COMPOSITIONS PERMETTANT DE GERER LE CHOLESTEROL ET LEURS UTILISATIONS
  申请人：ESPERION THERAPEUTICS INC

  公开号：WO2005047236A1

  公开（公告）日：2005-05-26

  The present invention relates to sulfoxide and bis-sulfoxide compounds of formula (I), formula (II), or formula (III), compositions comprising sulfoxide and bis-sulfoxide compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders comprising administering a composition comprising an ether compound. The compounds, compositions, and methods of the invention are also useful for treating and preventing Alzheimer's Disease, Syndrome X, peroxisome proliferator activated receptor-related disorders, septicemia, thrombotic disorders, obesity, pancreatitis, hypertension, renal disease, cancer, inflammation, and impotence. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.
• [EN] SUBSTITUTED THIOPHENE AMIDE COMPOUNDS FOR THE TREATMENT OF INFLAMMATION<br/>[FR] COMPOSES D'AMIDE A SUBSTITUTION DE THIOPHENE POUR LE TRAITEMENT DE L'INFLAMMATION.
  申请人：PHARMACIA & UPJOHN CO LLC

  公开号：WO2005105777A1

  公开（公告）日：2005-11-10

  IKK-2-inhibiting compounds of Formula I: wherein R, X, Y, Z, R3, R4, R5, and are as defined herein, are disclosed.

  公式I中抑制IKK-2的化合物：其中R、X、Y、Z、R3、R4、R5如本文所定义。