N-(4-(4-(6-(bis-(2-(tert-butyldimethylsilanyloxy)ethyl)amino)pyridin-2-yl)piperazin-1-yl)phenyl)-2-oxo-2-(2-phenylindolizin-3-yl)acetamide | 1029805-74-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: N-(4-(4-(6-(bis-(2-(tert-butyldimethylsilanyloxy)ethyl)amino)pyridin-2-yl)piperazin-1-yl)phenyl)-2-oxo-2-(2-phenylindolizin-3-yl)acetamide
• 英文别名: N-{4-[4-(6-{bis-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-amino}-pyridin-2-yl)-piperazin-1-yl]-phenyl}-2-oxo-2-(2-phenyl-indolizin-3-yl)-acetamide；N-[4-[4-[6-[bis[2-[tert-butyl(dimethyl)silyl]oxyethyl]amino]pyridin-2-yl]piperazin-1-yl]phenyl]-2-oxo-2-(2-phenylindolizin-3-yl)acetamide
• CAS: 1029805-74-0
• 化学式: C₄₇H₆₄N₆O₄Si₂
• 分子量: 833.234
• InChiKey: RARRYPCLSHASJO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.0
• 重原子数：
  59
• 可旋转键数：
  17
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  91.6
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  N-(4-(4-(6-(bis-(2-(tert-butyldimethylsilanyloxy)ethyl)amino)pyridin-2-yl)piperazin-1-yl)phenyl)-2-oxo-2-(2-phenylindolizin-3-yl)acetamide 在 四丁基氟化铵 作用下， 以 四氢呋喃 为溶剂， 反应 1.0h， 以36%的产率得到N-(4-(4-(6-(bis-(2-hydroxyethyl)amino)pyridin-2-yl)piperazin-1-yl)phenyl)-2-oxo-2-(2-phenylindolizin-3-yl)acetamide
  参考文献：
  名称：

  WO2008/62182

  摘要：

  公开号：

文献信息

• 2- [ (2-SUBSTITUTED) -IND0LIZIN-3-YL] -2-OXO-ACETAMIDE DERIVATIVES AS ANTIFUNGAL AGENTS
  申请人：Downham Robert

  公开号：US20100056511A1

  公开（公告）日：2010-03-04

  The invention provides compounds of formula (I), and pharmaceutically acceptable salts thereof wherein: R1, R2, R3, R4, R5, R6, R7, X and X 1 are as defined herein. These compounds are useful in the manufacture of medicaments for use in the prevention or treatment of a fungal disease. Compounds of formula (I), and agriculturally acceptable salts thereof, may also be used as agricultural fungicides.

  该发明提供了公式（I）的化合物及其药学上可接受的盐，其中：R1，R2，R3，R4，R5，R6，R7，X和X1如本文所定义。这些化合物在制造用于预防或治疗真菌病的药物方面是有用的。公式（I）的化合物及其农业上可接受的盐也可用作农业杀真菌剂。
• ANTIFUNGAL COMBINATION THERAPY
  申请人：Birch Michael

  公开号：US20110183969A1

  公开（公告）日：2011-07-28

  The invention provides pharmaceutical combinations comprising a combination of an antifungal indolizine compound of formula (I) or a pharmaceutically acceptable salt thereof and a second antifungal agent: wherein: R1, R2, R3, R4, R5, R6, R7, X and X 1 are as defined herein. The invention also provides pharmaceutical compositions comprising an antifungal indolizine compound of formula (I) or a pharmaceutically acceptable salt thereof, a second antifungal agent and a pharmaceutically acceptable diluent or carrier. The combinations and compositions are useful in the prevention or treatment of a fungal disease. A combination of an indolizine compound of formula (I) or agriculturally acceptable salts thereof and a second antifungal agent may also be used as an agricultural fungicide.

  本发明提供了药物组合物，包括式(I)的抗真菌吲哚啉化合物或其药学上可接受的盐和第二种抗真菌剂的组合：其中：R1，R2，R3，R4，R5，R6，R7，X和X1如本文所定义。本发明还提供了药物组合物，包括式(I)的抗真菌吲哚啉化合物或其药学上可接受的盐、第二种抗真菌剂和药学上可接受的稀释剂或载体。该组合物和组合物在预防或治疗真菌病方面是有用的。式(I)的吲哚啉化合物或其农业上可接受的盐和第二种抗真菌剂的组合也可用作农业杀菌剂。
• 2-[(2-substituted)-indolizin-3-yl]-2-oxo-acetamide derivatives as antifungal agents
  申请人：Downham Robert

  公开号：US08604029B2

  公开（公告）日：2013-12-10

  The invention provides compounds of formula (I), and pharmaceutically acceptable salts thereof wherein: R1, R2, R3, R4, R5, R6, R7, X and X1 are as defined herein. These compounds are useful in the manufacture of medicaments for use in the prevention or treatment of a fungal disease. Compounds of formula (I), and agriculturally acceptable salts thereof, may also be used as agricultural fungicides.

  本发明提供了以下式子(I)的化合物及其药学上可接受的盐，其中：R1、R2、R3、R4、R5、R6、R7、X和X1的定义如本文所述。这些化合物可用于制造用于预防或治疗真菌病的药物。式(I)的化合物及其农业上可接受的盐也可用作农业杀菌剂。